Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Angela Denzel"'
Publikováno v:
Journal of Biological Chemistry. 280:28265-28271
Calnexin and calreticulin are homologous lectin chaperones that assist maturation of cellular and viral glycoproteins in the mammalian endoplasmic reticulum. Calnexin and calreticulin share the same specificity for monoglucosylated protein-bound N-gl
Autor:
Adrian Hayday, Graham Anderson, Angela Denzel, Kevan M. Shokat, Katherine J. Hare, Chao Zhang, Eric J. Jenkinson
Publikováno v:
King's College London
To understand the regulatory activities of kinases in vivo requires their study across a biologically relevant window of activity. To this end, ATP analog-sensitive kinase alleles (ASKAs) specifically sensitive to a competitive inhibitor have been de
Publikováno v:
Immunology Letters. 86:1-6
Autor:
Joanne E. Martin, Angela Denzel, Maurizio Molinari, Michael John Owen, Shanti Velmurgan, Susan J. Brown, César Trigueros, Gordon Stamp
Publikováno v:
Molecular and Cellular Biology. 22:7398-7404
Calnexin is a ubiquitously expressed type I membrane protein which is exclusively localized in the endoplasmic reticulum (ER). In mammalian cells, calnexin functions as a chaperone molecule and plays a key role in glycoprotein folding and quality con
Publikováno v:
Blood. 90:873-885
Constitutive expression of a rat CD44 variant isoform, rCD44v4-v7, on murine T cells accelerates immune responsiveness. Because prolonged immunodeficiency can be a major drawback in allogeneic bone marrow transplantation, we considered it of special
Autor:
Kimberly C Gilmour, Tessa Crompton, Angela Denzel, Bjorn R. Olsen, Ian R Rosewell, Gordon Stamp, Stefan Mundlos, Rosa S.P Beddington, Florian Otto, Paul B. Selby, Michael John Owen, Anders P Thornell
Publikováno v:
Cell. 89:765-771
We have generated Cbfa1-deficient mice. Homozygous mutants die of respiratory failure shortly after birth. Analysis of their skeletons revealed an absence of osteoblasts and bone. Heterozygous mice showed specific skeletal abnormalities that are char
Publikováno v:
Journal of Leukocyte Biology. 60:579-592
The hematopoietic form of the adhesion molecule CD44 is known to be involved in lymphocyte maturation and homing. To define lineage and stage of maturation, which requires expression of CD44, murine long-term bone marrow cultures were established. St
Autor:
Angela Denzel, Wolfgang Zimmermann, David Anz, Christine Zoglmeier, Cornelia Wurzenberger, Carole Bourquin, Nadja Sandholzer, Stefan Endres, Philip von der Borch, Robert Kammerer, Nina Suhartha
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 185(4)
In stomach cancer, there is a need for new therapeutic strategies, in particular for the treatment of unresectable tumors and micrometastases. We investigated the efficacy of immunotherapy in an autochthonous model of gastric cancer, the CEA424-SV40
Publikováno v:
Biochimica et biophysica acta. 1493(1-2)
The Fas/Apo-1/CD95 cell surface receptor belongs to the TNF receptor family of cell death inducing molecules. A number of cytosolic adapter proteins that mediate signal transduction of CD95 have been characterized, but some features of the molecular
Autor:
R.C.E. Solarie, Rainer Pepperkok, Florian Otto, Ian R Rosewell, R. Watson, Angela Denzel, Michael John Owen, A. Girod, J.J.M. Bergeron
Publikováno v:
Current biology : CB. 10(1)
The p24 family of type I integral-membrane proteins, which are localised in the endoplasmic reticulum (ER) [1–3], the intermediate compartment and the Golgi apparatus, are thought to function as receptors for cargo exit from the ER and in transport