Výsledky vyhledávání - "Angela D Williams"

Akademický článek

Development and characterization of a prototypic pan-amyloid clearing agent – a novel murine peptide-immunoglobulin fusion

Autor: James S. Foster, Manasi Balachandran, Trevor J. Hancock, Emily B. Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D. Williams, Joseph W. Jackson, Stephen J. Kennel, Jonathan S. Wall

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionSystemic amyloidosis is a progressive disorder characterized by the extracellular deposition of amyloid fibrils and accessory proteins in visceral organs and tissues. Amyloid accumulation causes organ dysfunction and is not generally clea

Externí odkaz: https://doaj.org/article/3ce636148a204e3aafd0f0efaec0fd54

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Akademický článek

Anticytomegalovirus Peptides Point to New Insights for CMV Entry Mechanisms and the Limitations of In Vitro Screenings

Autor: Joseph W. Jackson, Trevor J. Hancock, Pranay Dogra, Ravi Patel, Ravit Arav-Boger, Angela D. Williams, Stephen J. Kennel, Jonathan S. Wall, Tim E. Sparer

Publikováno v: mSphere, Vol 4, Iss 1 (2019)

ABSTRACT Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that can cause severe disease following in utero exposure, during primary infection, or latent virus reactivation in immunocompromised populations. These complications lead to a 1-

Externí odkaz: https://doaj.org/article/bfe1c8b9badd479a977a7cc7b9f954e9

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Akademický článek

A Peptide-Fc Opsonin with Pan-Amyloid Reactivity

Autor: James S. Foster, Angela D. Williams, Sallie Macy, Tina Richey, Alan Stuckey, Daniel Craig Wooliver, Richa Koul-Tiwari, Emily B. Martin, Stephen J. Kennel, Jonathan S. Wall

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

There is a continuing need for therapeutic interventions for patients with the protein misfolding disorders that result in systemic amyloidosis. Recently, specific antibodies have been employed to treat AL amyloidosis by opsonizing tissue amyloid dep

Externí odkaz: https://doaj.org/article/77898dc3ab4441cdbcb2ebfc9ee72ae6

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Akademický článek

IgG Conformer's Binding to Amyloidogenic Aggregates.

Autor: Monichan Phay, Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Veronika Blinder, Tiernan T O'Malley, Alan Solomon, Dominic M Walsh, Brian O'Nuallain

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0137344 (2015)

Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the following three novel findi

Externí odkaz: https://doaj.org/article/d9c973e149054991ba50bef3823c4302

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First in Human Evaluation and Dosimetry Calculations for Peptide

Autor: Jonathan S, Wall, Emily B, Martin, Aaron, Endsley, Alan C, Stuckey, Angela D, Williams, Dustin, Powell, Bryan, Whittle, Sarah, Hall, Tyler R, Lambeth, Ryan R, Julian, Michael, Stabin, Ronald H, Lands, Stephen J, Kennel

Publikováno v: Molecular imaging and biology. 24(3)

Accurate diagnosis of amyloidosis remains a significant clinical challenge and unmet need for patients. The amyloid-reactive peptide p5+14 radiolabeled with iodine-124 has been developed for the detection of amyloid by PET/CT imaging. In a first-in-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a081654bcfb59baca79913553c509b5
https://pubmed.ncbi.nlm.nih.gov/34786667

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Akademický článek

Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide.

Autor: Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Luis Acero, Alfred Weber, Veronika Blinder, Alex Mably, Sebastian Bunk, Corinna Hermann, Michael A Farrell, Hartmut J Ehrlich, Hans P Schwarz, Dominic M Walsh, Alan Solomon, Brian O'Nuallain

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e50317 (2012)

Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer's disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precis

Externí odkaz: https://doaj.org/article/b5e5d024a32647f4acc8c5e30db8eff6

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Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs

Autor: Kathy A. Keith, Earl R. Kern, Emma A. Harden, Mark N. Prichard, Angela D. Williams

Publikováno v: Antiviral research. 71(1)

Orthopoxviruses and herpesviruses are both large enveloped DNA viruses, yet these virus families exhibit very different susceptibilities to antiviral drugs. We investigated the activation of nucleoside analogs by the types I and II thymidine kinase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d4e44e0596ddc0b258d1118c3a6c49
https://pubmed.ncbi.nlm.nih.gov/16530858

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