Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Angela Cowley"'
Autor:
John Robinson, Stuart P. McElroy, Philip S. Jones, Graeme Barker, Euan Parnell, Helma Rutjes, Lindsay Robinson, Angus Morrison, Elizabeth M. Beck, Andrew D. Pannifer, Martin Timmerman, Angela Cowley, Jolanta Wiejak, Veronique Hamon, Holger Rehmann, Urszula Luchowska-Stańska, Jonathan Gillespie, David Morgan, Stephen J. Yarwood, Alison Porter, Pravin Mahajan
Publikováno v:
Cells
Volume 8
Issue 11
Volume 8
Issue 11
Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677a116fcb1675edbcc36ca4fb30482f
https://pubmed.ncbi.nlm.nih.gov/31726720
https://pubmed.ncbi.nlm.nih.gov/31726720
Autor:
Richard Goodwin, Fiona Thomson, John W. Clark, Brad Sherborne, Lynn Watson, Angus R. Brown, Morag Grassie, Jack Pick, Angela Cowley, Olaf Nimz, J. Richard Morphy, Lorraine McIntosh, Niall M. Hamilton, Littlewood Peter Thomas Albert, Alasdair Smith, Koc-Kan Ho, Michael Speake, Alison Hillier, Ashvin Mistry, Michael Bosies, Simon James Anthony Grove, Mark Craighead, Theresa McIntyre, Michael Kiczun, Grant Emma Jane, Moira A. Elmore, Hannah Hampson, Mark Weston, Susan MacDonald, Susan Goutcher, Scott J. Lusher, Gayle Spinks, Zoran Rankovic, Michael Ohlmeyer, Helen Cameron, Alistair Firth, Steven G. Kultgen, Celia Kingsbury
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:137-140
High-throughput screening of 3.87 million compounds delivered a novel series of non-steroidal GR antagonists. Subsequent rounds of optimisation allowed progression from a non-selective ligand with a poor ADMET profile to an orally bioavailable, selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62da153327bd28fcc24657573e661d2
https://doi.org/10.1016/j.bmcl.2010.11.054
https://doi.org/10.1016/j.bmcl.2010.11.054
Publikováno v:
The Journal of the Acoustical Society of America. 128:2325-2325
Subjective and/or objective measurements of speech quality are important in benchmarking speech enhancement algorithms. Subjective measures include ratings of speech quality by listeners, whereas objective measures compute a metric based on the clean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf3be46f9b82c26cb44f65146ea9e208
https://doi.org/10.1121/1.3508205
https://doi.org/10.1121/1.3508205