Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Angela C. Zeigler"'
Autor:
Angela C. Zeigler, Anirudha S. Chandrabhatla, Steven L. Christiansen, Anders R. Nelson, Jeffrey W. Holmes, Jeffrey J. Saucerman
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 4, Pp 377-388 (2021)
Abstract Cardiac fibrosis is a significant component of pathological heart remodeling, yet it is not directly targeted by existing drugs. Systems pharmacology approaches have the potential to provide mechanistic frameworks with which to predict and u
Externí odkaz:
https://doaj.org/article/dd2b03b845534552804e89f52514c359
Autor:
Matthew W. Van de Graaf, Taylor G. Eggertsen, Angela C. Zeigler, Philip M. Tan, Jeffrey J. Saucerman
Publikováno v:
The Journal of Physiology.
Protein interaction databases are critical resources for network bioinformatics and integrating molecular experimental data. Interaction databases may also enable construction of predictive computational models of biological networks, although their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be08434b5f6f5e0e2fe174c5f0d7f29
https://doi.org/10.1113/jp284616
https://doi.org/10.1113/jp284616
Autor:
Jeffrey J. Saucerman, Jeffrey W. Holmes, Anders R. Nelson, Angela C. Zeigler, Olga Brazhkina, Anirudha S. Chandrabhatla
Publikováno v:
Matrix Biol
The fibroblast is a key mediator of wound healing in the heart and other organs, yet how it integrates multiple time-dependent paracrine signals to control extracellular matrix synthesis has been difficult to study in vivo. Here, we extended a comput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da570e872451a0f4245d576879cd028
https://doi.org/10.1016/j.matbio.2020.03.007
https://doi.org/10.1016/j.matbio.2020.03.007
Publikováno v:
Am J Perinatol
Objective Scores to predict sepsis or define sepsis severity could improve care for very low birth weight (VLBW) infants. The heart rate characteristics (HRC) index (HeRO score) was developed as an early warning system for late-onset sepsis (LOS), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15e75d4178a4e37efba486485113c09
https://pubmed.ncbi.nlm.nih.gov/33971672
https://pubmed.ncbi.nlm.nih.gov/33971672
Autor:
Angela N. Lewis, Brynne A. Sullivan, L. Anne Walker, Mhd Wael Alrifai, Camilia R. Martin, Sarah A. Coggins, Richard A. Polin, Ameena N. Husain, Misty Good, Douwe H. Visser, Aaron Wallman-Stokes, James L. Wynn, Angela C. Zeigler, Brenda S. de Jong, Krista Cooksey, Noa Fleiss
Publikováno v:
JAMA Network Open
JAMA network open, 4(2):e2036518. American Medical Association
JAMA network open, 4(2):e2036518. American Medical Association
Key Points Question How useful is the neonatal Sequential Organ Failure Assessment for identification of preterm infants at high risk for late-onset, infection-associated mortality? Findings In this multicenter cohort study of 653 preterm infants wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43681db2692a234f616bc85a76ffeead
https://doi.org/10.1001/jamanetworkopen.2020.36518
https://doi.org/10.1001/jamanetworkopen.2020.36518
Autor:
Xiaji Liu, Anders R. Nelson, Jeffrey J. Saucerman, Angela C. Zeigler, Jingyuan Zhang, Merry L. Lindsey
Publikováno v:
J Immunol
Macrophages are subject to a wide range of cytokine and pathogen signals in vivo, which contribute to differential activation and modulation of inflammation. Understanding the response to multiple, often conflicting, cues that macrophages experience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16851e10988c22992256828bc1f76b29
https://doi.org/10.1101/844464
https://doi.org/10.1101/844464
Publikováno v:
Journal of Molecular and Cellular Cardiology. 94:72-81
Cardiac fibroblasts support heart function, and aberrant fibroblast signaling can lead to fibrosis and cardiac dysfunction. Yet how signaling molecules drive myofibroblast differentiation and fibrosis in the complex signaling environment of cardiac i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d024a4eef026fc6faadeb34a8f2e945a
https://doi.org/10.1016/j.yjmcc.2016.03.008
https://doi.org/10.1016/j.yjmcc.2016.03.008
Publikováno v:
Journal of Molecular and Cellular Cardiology. 93:73-83
Altered fibroblast behavior can lead to pathologic changes in the heart such as arrhythmia, diastolic dysfunction, and systolic dysfunction. Computational models are increasingly used as a tool to identify potential mechanisms driving a phenotype or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835d67b25b39d0cdee89d080c7b1f353
https://doi.org/10.1016/j.yjmcc.2015.11.020
https://doi.org/10.1016/j.yjmcc.2015.11.020
Publikováno v:
Physiology (Bethesda, Md.). 29(4)
A vast amount of investigation has centered on how the endothelium and smooth muscle communicate. From this evidence, myoendothelial junctions have emerged as critical anatomical structures to regulate heterocellular cross talk. Indeed, there is now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0435031ff4c521b2b29d75fdea9f0d
https://pubmed.ncbi.nlm.nih.gov/24985328
https://pubmed.ncbi.nlm.nih.gov/24985328