Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Angela C. Spencer"'
Autor:
Angela C. Spencer, Siva S. Panda
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 371 (2023)
Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new antibacterials. DNA gyrase is one of the primary targets of quinolones, broad-spec
Externí odkaz:
https://doaj.org/article/0d6a744351d74613823791094d88ed2f
Autor:
Linda L. Spremulli, Domenick Grasso, Angela C. Spencer, P. D. V. Krishna, Partha P. Datta, Rahul Gaur, Rajendra K. Agrawal, Umesh Varshney, Gautam Das
Publikováno v:
Molecular Cell. 29:180-190
The mechanism of translation in eubacteria and organelles is thought to be similar. In eubacteria, the three initiation factors IF1, IF2, and IF3 are vital. Although the homologs of IF2 and IF3 are found in mammalian mitochondria, an IF1 homolog has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516a3c6e2f8189c46fd26f68fdf0629a
https://doi.org/10.1016/j.molcel.2007.11.021
https://doi.org/10.1016/j.molcel.2007.11.021
Two mammalian mitochondrial initiation factors have been identified. Initiation factor 2 (IF2 mt ) selects the initiator tRNA (fMet-tRNA) and promotes its binding to the ribosome. Initiation factor 3 (IF3 mt ) promotes the dissociation of the 55S mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb732dd7d28ae690505664991c548538
https://doi.org/10.1016/s0076-6879(07)30004-9
https://doi.org/10.1016/s0076-6879(07)30004-9
Autor:
Michele DeRider, Angela C. Spencer, Linda L. Spremulli, Jennifer L. Hsu, Paul F. Agris, Christopher I. Jones, Susan A. Martinis
Mitochondrial tRNAs (mtRNAs) often lack domains and posttranscriptional modifications that are found in cytoplasmic tRNAs. These structural and chemical elements normally stabilize the folding of cytoplasmic tRNAs into canonical structures that are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb689fa26c4ab78e399dd7d695a7f06e
https://europepmc.org/articles/PMC1781928/
https://europepmc.org/articles/PMC1781928/
Autor:
Linda L. Spremulli, Angela C. Spencer
Publikováno v:
Biochimica et biophysica acta. 1750(1)
Bovine mitochondrial translational initiation factor 2 (IF-2 mt ) is organized into four domains, an N-terminal domain, a central G-domain and two C-terminal domains. These domains correspond to domains III–VI in the six-domain model of Escherichia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbf73a49d6d31d0a5f820abc8758745
https://pubmed.ncbi.nlm.nih.gov/15935986
https://pubmed.ncbi.nlm.nih.gov/15935986
Autor:
Linda L. Spremulli, Angela C. Spencer
Publikováno v:
Nucleic acids research. 32(18)
The mammalian mitochondrial genome contains a single tRNA(Met) gene that gives rise to the initiator and elongator tRNA(Met). It is generally believed that mitochondrial protein synthesis begins with formylmethionyl-tRNA, which indicates that the for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad85fea4530cc67f1903b310b526e37
https://pubmed.ncbi.nlm.nih.gov/15477394
https://pubmed.ncbi.nlm.nih.gov/15477394
Publikováno v:
Biochemistry. 43(30)
Human mitochondrial methionyl-tRNA synthetase (human mtMetRS) has been identified from the human EST database. The cDNA encodes a 593 amino acid protein with an 18 amino acid mitochondrial import signal sequence. Sequence analysis indicates that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3652fd366fc99a4bc61ded3d5ed59bc
https://pubmed.ncbi.nlm.nih.gov/15274629
https://pubmed.ncbi.nlm.nih.gov/15274629