Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

Autor: Ntsiki M. Held, M. Renate Buijink, Hyung L. Elfrink, Sander Kooijman, Georges E. Janssens, Angela C. M. Luyf, Mia L. Pras-Raves, Frédéric M. Vaz, Stephan Michel, Riekelt H. Houtkooper, Michel van Weeghel

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we in

Externí odkaz: https://doaj.org/article/9c02010f9abc4c868131db2f81cf7e9b

Mutations in PCYT2 disrupt etherlipid biosynthesis and cause a complex hereditary spastic paraplegia

Autor: Saskia B. Wortmann, Simon C. Lovell, Antoine H. C. van Kampen, Stefan Kölker, Martin Lowe, Sacha Ferdinandusse, Peter E. Clayton, Angela C. M. Luyf, Ronald J.A. Wanders, Richard C. Rogers, Siddharth Banka, Sara Cuvertino, Kay Metcalfe, Marc Engelen, Martin A. T. Vervaart, Hyung L. Elfrink, Rebecca Yarwood, Mia L. Pras-Raves, John H McDermott, Michel van Weeghel, Deciphering Developmental Disorders Study, Jos P.N. Ruiter, Henk van Lenthe, Marielle Alders, Frédéric M. Vaz

Publikováno v: Brain
Brain 142, 3382-3397 (2019)
Mcdermott, J, Metcalfe, K, Banka, S, Cuvertino, S, Clayton, P, Yarwood, R, Lowe, M & Lovell, S 2019, ' Mutations in PCYT2 disrupt etherlipid biosynthesis and cause a complex hereditary spastic paraplegia ', Brain : a journal of neurology, vol. 142, no. 11, pp. 3382-3397 . https://doi.org/10.1093/brain/awz291
Brain, 142(11), 3382-3397. Oxford University Press

Vaz, McDermott et al. identify variants in PCYT2, which encodes a key gene in phospholipid biosynthesis, in five individuals with a new complex hereditary spastic paraplegia. Functional studies in fibroblasts and a zebrafish model confirm the pathoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72b021479bf3fac2b35039a421047e5
http://europepmc.org/articles/PMC6821184

Metabolomics and lipidomics in C. elegans using a single sample preparation

Autor: Georges E. Janssens, Angela C. M. Luyf, Martin A. T. Vervaart, Hyung L. Elfrink, Bauke V. Schomakers, Marte Molenaars, Jan E. Kammenga, Arwen W. Gao, Michel van Weeghel, Reuben L. Smith, Frédéric M. Vaz, Mia L. Pras-Raves, Mark G. Sterken, Antoine H C van Kampen, Riekelt H. Houtkooper

Comprehensive metabolomic and lipidomic mass spectrometry methods are in increasing demand, for instance in research related to nutrition and aging. The nematode C. elegans is a key model organism in these fields, due to the large repository of avail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f0c0d6b93ec06294d362f172392cd9c
https://doi.org/10.1101/2020.07.06.190017

Plasma lipidomics as a diagnostic tool for peroxisomal disorders

Autor: Frédéric M. Vaz, Katharina Herzog, Sacha Ferdinandusse, Angela C. M. Luyf, Ronald J.A. Wanders, Mia L. Pras-Raves, Antoine H. C. van Kampen, Martin A. T. Vervaart, Hans R. Waterham

Publikováno v: Journal of inherited metabolic disease, 41(3). Springer Netherlands
Journal of Inherited Metabolic Disease, 41(3), 489-498. Springer Netherlands
Journal of inherited metabolic disease, 41(3), 489-498. Springer Netherlands
Journal of Inherited Metabolic Disease

Peroxisomes are ubiquitous cell organelles that play an important role in lipid metabolism. Accordingly, peroxisomal disorders, including the peroxisome biogenesis disorders and peroxisomal single-enzyme deficiencies, are associated with aberrant lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b6757207d0874c446792fd3bf70de6
https://doi.org/10.1007/s10545-017-0114-7

Lipidomic analysis of fibroblasts from Zellweger spectrum disorder patients identifies disease-specific phospholipid ratios

Autor: Katharina Herzog, Antoine H. C. van Kampen, Hans R. Waterham, Martin A. T. Vervaart, Frédéric M. Vaz, Mia L. Pras-Raves, Angela C. M. Luyf, Ronald J.A. Wanders

Publikováno v: Journal of lipid research, 57(8), 1447-1454. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 57, Iss 8, Pp 1447-1454 (2016)
Journal of Lipid Research, 57(8), 1447-1454. American Society for Biochemistry and Molecular Biology Inc.

Peroxisomes are subcellular organelles involved in various metabolic processes, including fatty acid and phospholipid homeostasis. The Zellweger spectrum disorders (ZSDs) represent a group of diseases caused by a defect in the biogenesis of peroxisom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77eb68a8b8c008c23f4eb6ed95b8bd4
https://pure.amc.nl/en/publications/lipidomic-analysis-of-fibroblasts-from-zellweger-spectrum-disorder-patients-identifies-diseasespecific-phospholipid-ratios(7267a522-7712-43af-a85d-c23983806a2c).html