Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Angela C Hirbe"'
Autor:
Brian A Van Tine, Mia C Weiss, Angela C Hirbe, Peter J Oppelt, Sarah Abaricia, Kathryn Trinkaus, Jingqin Luo, Shellie Berry, Tyler Ruff, Cheryl Callahan, Jacqui Toensikoetter, Jessica Ley, Marilyn J Siegel, Farrokh Dehdashti, Barry A Siegel, Douglas R Adkins
Publikováno v:
Rare Tumors, Vol 13 (2021)
Historically, administration of dacarbazine to sarcoma patients was limited by frequent treat-ment-related nausea/vomiting and neutropenia. These toxicities are now largely preventable with contemporary antiemetics and growth factor support. In this
Externí odkaz:
https://doaj.org/article/ef35792130554864b05b1722df7d26bf
Autor:
Jeffrey J Szymanski, R Taylor Sundby, Paul A Jones, Divya Srihari, Noah Earland, Peter K Harris, Wenjia Feng, Faridi Qaium, Haiyan Lei, David Roberts, Michele Landeau, Jamie Bell, Yi Huang, Leah Hoffman, Melissa Spencer, Matthew B Spraker, Li Ding, Brigitte C Widemann, Jack F Shern, Angela C Hirbe, Aadel A Chaudhuri
Publikováno v:
PLoS Medicine, Vol 18, Iss 8, p e1003734 (2021)
BackgroundThe leading cause of mortality for patients with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the development of malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma. In the setting of N
Externí odkaz:
https://doaj.org/article/c4e51b3f384e4d0d940d39076a2a352f
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Neurofibromatosis type 1 (NF1), the most common tumor predisposition syndrome, occurs when NF1 gene variants result in loss of neurofibromin, a negative regulator of RAS activity. Plexiform neurofibromas (PN) are peripheral nerve sheath tumo
Externí odkaz:
https://doaj.org/article/e7e7711405894d27acfa73a6504142c7
Autor:
Dana C. Borcherding, Neha V. Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Carina Dehner, Himanshi Bhatia, Angad Gothra, Layla Daud, Peter Ruminski, Christine A. Pratilas, Kai Pollard, Taylor Sundby, Brigitte C. Widemann, Angela C. Hirbe
Publikováno v:
Clinical Cancer Research. 29:1592-1604
Purpose: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases are associated with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6376177010a995b701dd6baf6516d887
https://doi.org/10.1158/1078-0432.ccr-22-3722
https://doi.org/10.1158/1078-0432.ccr-22-3722
Autor:
Carina A. Dehner, Tyler Moon, Yang Lyu, Xiaochun Zhang, Zhaohe Zhou, Kuangying Yang, John S. A. Chrisinger, Anthony Griffin, Jay Wunder, Brendan C. Dickson, Angela C. Hirbe
Publikováno v:
Genes, Chromosomes and Cancer. 62:301-307
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::641f05ebf5c0e6f0f5e9181464af2e94
https://doi.org/10.1002/gcc.23123
https://doi.org/10.1002/gcc.23123
Autor:
Isidro, Cortes-Ciriano, Christopher D, Steele, Katherine, Piculell, Alyaa, Al-Ibraheemi, Vanessa, Eulo, Marilyn M, Bui, Aikaterini, Chatzipli, Brendan C, Dickson, Dana C, Borcherding, Andrew, Feber, Alon, Galor, Jesse, Hart, Kevin B, Jones, Justin T, Jordan, Raymond H, Kim, Daniel, Lindsay, Colin, Miller, Yoshihiro, Nishida, Paula Z, Proszek, Jonathan, Serrano, R Taylor, Sundby, Jeffrey J, Szymanski, Nicole J, Ullrich, David, Viskochil, Xia, Wang, Matija, Snuderl, Peter J, Park, Adrienne M, Flanagan, Angela C, Hirbe, Nischalan, Pillay, David T, Miller
Publikováno v:
Cancer Discovery. 13:654-671
Malignant peripheral nerve sheath tumor (MPNST), an aggressive soft-tissue sarcoma, occurs in people with neurofibromatosis type 1 (NF1) and sporadically. Whole-genome and multiregional exome sequencing, transcriptomic, and methylation profiling of 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af47f0e457c5aa96b953dcac0b29aac9
https://doi.org/10.1158/2159-8290.cd-22-0786
https://doi.org/10.1158/2159-8290.cd-22-0786
Autor:
Alex T Larsson, Himanshi Bhatia, Ana Calizo, Kai Pollard, Xiaochun Zhang, Eric Conniff, Justin F Tibbitts, Elizabeth Rono, Katherine Cummins, Sara H Osum, Kyle B Williams, Alexandra L Crampton, Tyler Jubenville, Daniel Schefer, Kuangying Yang, Yang Lyu, James C Pino, Jessica Bade, John M Gross, Alla Lisok, Carina A Dehner, John S A Chrisinger, Kevin He, Sara J C Gosline, Christine A Pratilas, David A Largaespada, David K Wood, Angela C Hirbe
Publikováno v:
Neuro-Oncology.
Background Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that often develop in patients with neurofibromatosis type 1 (NF1). To address the critical need for novel therapeutics in MPNST, we aimed to establish an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6039c6fd8a56c7fa88ceae08ddd8c926
https://doi.org/10.1093/neuonc/noad097
https://doi.org/10.1093/neuonc/noad097
Autor:
Nam Bui, Hilary Dietz, Sheima Farag, Angela C. Hirbe, Michael J. Wagner, Brian A. Van Tine, Kristen Ganjoo, Robin L. Jones, Vicki L. Keedy, Elizabeth J. Davis
Publikováno v:
Cancers; Volume 15; Issue 9; Pages: 2617
Background: Dedifferentiated chondrosarcoma (DDCS) is a rare subset of chondrosarcoma. It is an aggressive neoplasm characterized by a high rate of recurrent and metastatic disease with overall poor outcomes. Systemic therapy is often used to treat D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c12fc30f220e37698d753955800917
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplemental Fig.S5. Validation of select gene expression changes with TYK2 inhibitor treatment that were identified by qPCR array. JH-2-002 cells were incubated with 40 µMWU-12 or control for 48 hours, and gene expression was analyzed by qPCR for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9731d69082d42fc007e50b47eee746df
https://doi.org/10.1158/1078-0432.22632929
https://doi.org/10.1158/1078-0432.22632929
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Purpose:Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases are associated with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8930420b460dd667c263399c108f1bcc
https://doi.org/10.1158/1078-0432.c.6533056
https://doi.org/10.1158/1078-0432.c.6533056