Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Angela C Gomez"'
Autor:
Fangyuan Chen, Qingya Shi, Fen Pei, Andreas Vogt, Rebecca A Porritt, Gustavo Garcia, Angela C Gomez, Mary Hongying Cheng, Mark E Schurdak, Bing Liu, Stephen Y Chan, Vaithilingaraja Arumugaswami, Andrew M Stern, D Lansing Taylor, Moshe Arditi, Ivet Bahar
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 8, Pp 1-23 (2021)
Abstract Understanding the mechanism of SARS‐CoV‐2 infection and identifying potential therapeutics are global imperatives. Using a quantitative systems pharmacology approach, we identified a set of repurposable and investigational drugs as poten
Externí odkaz:
https://doaj.org/article/7db43c04a84b4afb9367c079ed650876
Autor:
Asima Chakraborty, Daniel A Pasek, Tai-Qin Huang, Angela C Gomez, Naohiro Yamaguchi, Mark E Anderson, Gerhard Meissner
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104338 (2014)
In cardiac muscle, the release of calcium ions from the sarcoplasmic reticulum through ryanodine receptor ion channels (RyR2s) leads to muscle contraction. RyR2 is negatively regulated by calmodulin (CaM) and by phosphorylation of Ca2+/CaM-dependent
Externí odkaz:
https://doaj.org/article/2c7ef560bb6e49e5aa3ee8fb6c33ffea
Autor:
Prasant Jena, Daiko Wakita, Angela C Gomez, Thacyana T Carvalho, Meena Narayanan, Youngho Lee, Patrice D Cani, Willem M De Vos, Shuang Chen, Timothy R Crother, Kenichi Shimada, Moshe Arditi, Magali Noval Rivas
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Changes in intestinal microbiota composition and function are associated with development of cardiovascular disease, but the role of these alterations remains unclear in Kawasaki Disease (KD), an acute pediatric vasculitis that targets coronary arter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82350348c6662cacd78ee7b9e1e725e5
https://doi.org/10.1161/atvb.42.suppl_1.331
https://doi.org/10.1161/atvb.42.suppl_1.331
Autor:
D. D. Rastelli, M. Noval Rivas, Michael C. Fishbein, Thomas J. A. Lehman, Moshe Arditi, E. Cingolani, Youngho Lee, Masanori Abe, Kenichi Shimada, P. R. Soni, Shuang Chen, Timothy R. Crother, Angela C. Gomez
Publikováno v:
Clin Exp Immunol
Summary Kawasaki disease (KD) is the leading cause of acquired heart disease in children. In addition to coronary artery abnormalities, aneurysms and myocarditis, acute KD is also associated with echocardiogram (ECG) abnormalities in 40–80% of pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9534fb712643438ce1e565986bb4ecdf
https://doi.org/10.1111/cei.13401
https://doi.org/10.1111/cei.13401
Autor:
Stefanie Marek-Iannucci, Asli D. Yildirim, Syed M. Hamid, Asli B. Ozdemir, Angela C. Gomez, Begüm Kocatürk, Rebecca A. Porritt, Michael C. Fishbein, Takao Iwawaki, Magali Noval Rivas, Ebru Erbay, Moshe Arditi
Publikováno v:
JCI insight. 7(6)
Kawasaki disease (KD) is the leading cause of noncongenital heart disease in children. Studies in mice and humans propound the NLRP3/IL-1β pathway as the principal driver of KD pathophysiology. Endoplasmic reticulum (ER) stress can activate the NLRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a4e32a71d7899d890f4b1931fa36f3
https://pubmed.ncbi.nlm.nih.gov/35167493
https://pubmed.ncbi.nlm.nih.gov/35167493
Autor:
Elsa Sanchez-Lopez, Youngho Lee, David Zemmour, Angela C. Gomez, Asli Beyza Ozdemir, Jennifer E. Van Eyk, Aleksandr Stotland, Rebecca A. Porritt, Michael C. Fishbein, Timothy R. Crother, Stefanie Marek-Iannucci, Debbie Moreira, Michael Karin, Magali Noval Rivas, Malcolm Lane, Sarah J. Parker, Masanori Abe, Kenichi Shimada, Moshe Arditi, Roberta A. Gottlieb
Publikováno v:
JCI insight, vol 6, iss 18
JCI Insight
JCI Insight
Kawasaki disease (KD) is the leading cause of acquired heart disease among children. Murine and human data suggest that the NLRP3-IL-1β pathway is the main driver of KD pathophysiology. NLRP3 can be activated during defective autophagy/mitophagy. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cced1353899834b22bf69b224c6fe5
https://escholarship.org/uc/item/77z6x69j
https://escholarship.org/uc/item/77z6x69j
Autor:
David Zemmour, Rebecca A. Porritt, Youngho Lee, Michael C. Fishbein, Angela C. Gomez, Masanori Abe, Timothy R. Crother, Meena Meena Narayanan, Kenichi Shimada, Shuang Chen, Thacyana T. Carvalho, Daisy Martinon, Moshe Arditi, Magali Noval Rivas, Chintda Santiskulvong
Publikováno v:
Circ Res
Rationale:NLRP3 (NLR family pyrin domain containing 3) activation and IL-1β (interleukin-1β) production are implicated in Kawasaki disease (KD) pathogenesis; however, a detailed and complete characterization of the molecular networks and cellular s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eae0cc14f209158224c3377e4c4ba9d
https://europepmc.org/articles/PMC8555446/
https://europepmc.org/articles/PMC8555446/
Autor:
Angela C. Gomez, Gustavo Garcia, Moshe Arditi, Andrew M. Stern, Qingya Shi, Vaithilingaraja Arumugaswami, Stephen Y. Chan, Ivet Bahar, Fangyuan Chen, Mary Hongying Cheng, Mark E. Schurdak, Fen Pei, D. Lansing Taylor, Andreas Vogt, Bing Liu, Rebecca A. Porritt
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 17, Iss 8, Pp n/a-n/a (2021)
Molecular Systems Biology, Vol 17, Iss 8, Pp n/a-n/a (2021)
Understanding the mechanism of SARS‐CoV‐2 infection and identifying potential therapeutics are global imperatives. Using a quantitative systems pharmacology approach, we identified a set of repurposable and investigational drugs as potential ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06aaa90ad56837dc984791eeafb6b598
https://pubmed.ncbi.nlm.nih.gov/34339582
https://pubmed.ncbi.nlm.nih.gov/34339582
Autor:
Rebecca A. Porritt, Carol Chase Huizar, Edward J. Dick, Shyamesh Kumar, Renee Escalona, Angela C. Gomez, Stefani Marek-Iannucci, Magali Noval Rivas, Jean Patterson, Thomas G. Forsthuber, Moshe Arditi, Mark Gorelik
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
ObjectiveKawasaki disease (KD) is the most common cause of acquired pediatric heart disease in the developed world. 10% of KD patients are resistant to front-line therapy, and no interventions exist to address secondary complications such as myocardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4dc2ef56ce2c7d2ba07cc6f6fc5bb31
https://doi.org/10.3389/fimmu.2021.630196
https://doi.org/10.3389/fimmu.2021.630196
Autor:
Debbie Moreira, Malcolm Lane, Magali Noval Rivas, Youngho Lee, Kenichi Shimada, Timothy R. Crother, Stefanie Marek-Iannucci, Rebecca A. Porritt, Moshe Arditi, Angela C. Gomez
Publikováno v:
Circulation. 142
Kawasaki Disease (KD), an acute febrile illness and systemic vasculitis of unknown etiology, is the leading cause of acquired heart disease among children. Recent experimental data from mouse models, as well as clinical, genetic and transcriptome evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa34eddfe0578e043c39401257e0aafc
https://doi.org/10.1161/circ.142.suppl_3.12638
https://doi.org/10.1161/circ.142.suppl_3.12638