Výsledky vyhledávání - "Angela C Gelli"

Cryptococcal Meningitis and Anti-virulence Therapeutic Strategies

Autor: Kiem Vu, Angela C Gelli, Javier A Garcia

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)
Frontiers in microbiology, vol 10, iss FEB
Frontiers in Microbiology

Fungal infections of the central nervous system are responsible for significant morbidity and mortality. Cryptococcus neoformans (Cn) is the primary cause of fungal meningitis. Infection begins in the lung after inhalation of fungal spores but often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4217cd9967e077506f920247890b435
https://www.frontiersin.org/article/10.3389/fmicb.2019.00353/full

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Fluconazole Susceptibility in Cryptococcus gattii Is Dependent on the ABC Transporter Pdr11

Autor: Angela C Gelli, Kiem Vu, George Richard Thompson, Mai Lee Yang, John P. Uhrig, Anil Singapuri, Michael Dennis

Publikováno v: Antimicrobial agents and chemotherapy, vol 60, iss 3

Cryptococcus gattii isolates from the Pacific Northwest have exhibited higher fluconazole MICs than isolates from other sites. The mechanism of fluconazole resistance in C. gattii is unknown. We sought to determine the role of the efflux pumps Mdr1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ffd87d3c71d7effbdb2e20a4339349
https://doi.org/10.1128/aac.01777-15

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The structure-function analysis of the Mpr1 metalloprotease determinants of activity during migration of fungal cells across the blood-brain barrier

Autor: Angela C Gelli, John P. Uhrig, Sarisa Na Pombejra, Mantana Jamklang, Kiem Vu

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0203020 (2018)
PloS one, vol 13, iss 8

Cryptococcal meningoencephalitis, the most common form of cryptococcosis, is caused by the opportunistic fungal pathogen, Cryptococcus neoformans. Molecular strategies used by C. neoformans to invade the central nervous system (CNS) have been the foc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd15c9943f74a91a040229a1cb07379
http://europepmc.org/articles/PMC6117016?pdf=render

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A unique cytoskeleton-associated protein in Cryptococcus neoformans

Autor: Angela C Gelli

Publikováno v: Virulence, Vol 9, Iss 1, Pp 752-753 (2018)
Virulence

Microtubules are involved in mechanical support, cytoplasmic organization, and several cellular processes by interacting with diverse microtubule-associated proteins such as plus-end tracking proteins, motor proteins, and tubulin-folding cofactors. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4851e827963af4b4124b8e7688e64152
https://doaj.org/article/a5f9521289c545cd9361a031132f0b41

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Flucytosine resistance in Cryptococcus gattii is indirectly mediated by the FCY2-FCY1-FUR1 pathway

Autor: Jane E. Sykes, Kiem Vu, Elizabeth M. Dreibe, Angela C Gelli, Shawn R. Lockhart, George Richard Thompson, David M. Engelthaler, Wieland Meyer, Chandler C. Roe

Publikováno v: Medical mycology. 56(7)

Cryptococcosis is an opportunistic fungal infection caused by members of the two sibling species complexes: Cryptococcus neoformans and Cryptococcus gattii. Flucytosine (5FC) is one of the most widely used antifungals against Cryptococcus spp., yet v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7c2719c6ad803c7ed83e382ed43736
https://pubmed.ncbi.nlm.nih.gov/29554336

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The Metalloprotease, Mpr1, Engages AnnexinA2 to Promote the Transcytosis of Fungal Cells across the Blood-Brain Barrier

Autor: Michelle Salemi, Brett S. Phinney, Angela C Gelli, Sarisa Na Pombejra

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Frontiers in Cellular and Infection Microbiology
Frontiers in cellular and infection microbiology, vol 7, iss JUN

Eukaryotic pathogens display multiple mechanisms for breaching the blood-brain barrier (BBB) and invading the central nervous system (CNS). Of the fungal spp., that cause disease in mammals, only some cross brain microvascular endothelial cells which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1895661971bd31902b0cd360813715c
http://journal.frontiersin.org/article/10.3389/fcimb.2017.00296/full

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Cryptococcus neoformans Promotes Its Transmigration into the Central Nervous System by Inducing Molecular and Cellular Changes in Brain Endothelial Cells

Autor: Kiem Vu, Richard A. Eigenheer, Angela C Gelli, Brett S. Phinney

Publikováno v: Infection and Immunity. 81:3139-3147

Cryptococcus spp. cause fungal meningitis, a life-threatening infection that occurs predominately in immunocompromised individuals. In order for Cryptococcus neoformans to invade the central nervous system (CNS), it must first penetrate the brain end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4367c4b6b2228d598a572aaa6d2526b
https://doi.org/10.1128/iai.00554-13

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Activity of the Calcium Channel Pore Cch1 Is Dependent on a Modulatory Region of the Subunit Mid1 in Cryptococcus neoformans

Autor: Jennifer M. Bautos, Kiem Vu, Mantana Jamklang, Min Pyo Hong, Rick C. Tham, Angela C Gelli, John P. Uhrig

Publikováno v: Eukaryotic Cell. 12:142-150

Calcium (Ca 2+ )-mediated signaling events in fungal pathogens such as Cryptococcus neoformans are central to physiological processes, including those that mediate stress responses and promote virulence. The Cch1-Mid1 channel (CMC) represents the onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af63d4e890a72df8f5b73bdd71ec50de
https://doi.org/10.1128/ec.00130-12

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In vivo development of fluconazole resistance in serial Cryptococcus gattii isolates from a cat

Autor: George Richard Thompson, Anil Singapuri, Greg Hodge, Mai Lee Yang, Jane E. Sykes, Angela C Gelli

Publikováno v: Medical mycology. 55(4)

Elevated fluconazole minimum inhibitory concentrations (MICs) are more frequently observed in Cryptococcus gattii compared to C. neoformans isolates; however, the development of in vivo resistance and the molecular mechanisms responsible have not bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6946b0744b7331f90c50e7102d3c385
https://pubmed.ncbi.nlm.nih.gov/28339594

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Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress

Autor: Jennifer M. Bautos, Kiem Vu, Angela C Gelli, Min Pyo Hong

Publikováno v: Journal of Biological Chemistry. 285:10951-10958

Pathogens endure and proliferate during infection by exquisitely coping with the many stresses imposed by the host to prevent pathogen survival. Recent evidence has shown that fungal pathogens and yeast respond to insults to the endoplasmic reticulum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f45792e057ae44da62e86ca11372384
https://doi.org/10.1074/jbc.m109.056218

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