Výsledky vyhledávání - "Angela Bik Yu Hui"

Akademický článek

Phase II Trial of Regorafenib and Oral Methotrexate in Previously Treated Advanced KRAS-Mutant NSCLC

Autor: Jacqueline V. Aredo, MD, MS, Heather A. Wakelee, MD, Kavitha J. Ramchandran, MD, Joel W. Neal, MD, PhD, Maximilian Diehn, MD, PhD, Angela Bik-Yu Hui, PhD, Ameen Salahudeen, MD, PhD, Bernice Kwong, MD, Gerald J. Berry, MD, H. Henry Guo, MD, PhD, Kristen Cunanan, PhD, Shireen Vali, PhD, Danny Pancirer, BA, Vivian Tsang, MSN, Grace Hwang, MS, Monica Loza, BA, Brittany Johnson, BA, Isabelle Blanchard, BS, Sukhmani K. Padda, MD

Publikováno v: JTO Clinical and Research Reports, Vol 5, Iss 12, Pp 100741- (2024)

Introduction: There are no standard targeted treatment options for advanced KRAS-mutant NSCLC beyond KRAS G12C inhibitors. A computational model identified regorafenib and low-dose methotrexate as synergistic in preclinical models of KRAS-mutant NSCL

Externí odkaz: https://doaj.org/article/568d1ca40dcd476cba01bc859c5cbee5

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Akademický článek

Quantification of cerebrospinal fluid tumor DNA in lung cancer patients with suspected leptomeningeal carcinomatosis

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-10 (2024)

Abstract Cerebrospinal fluid tumor-derived DNA (CSF-tDNA) analysis is a promising approach for monitoring the neoplastic processes of the central nervous system. We applied a lung cancer-specific sequencing panel (CAPP-Seq) to 81 CSF, blood, and tiss

Externí odkaz: https://doaj.org/article/eaae1e7a290d44c69e031450a6628a56

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Akademický článek

A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk

Publikováno v: Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)

Abstract Background Tumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and

Externí odkaz: https://doaj.org/article/cc0f2098680f4d72b3ab8a49201dc29f

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Akademický článek

Induction EGFR tyrosine kinase inhibitors prior to definitive chemoradiotherapy in unresectable stage III EGFR-mutated non-small cell lung cancer

Autor: Jacqueline V. Aredo, Heather A. Wakelee, Angela Bik-Yu Hui, Sukhmani K. Padda, Nitin D. Joshi, H. Henry Guo, Aadel Chaudhuri, Maximilian Diehn, Billy W. Loo, Jr., Joel W. Neal

Publikováno v: Cancer Treatment and Research Communications, Vol 33, Iss , Pp 100659- (2022)

Introduction: Increasing evidence suggests that consolidation durvalumab confers limited benefits for patients with stage III EGFR-mutated NSCLC. Induction or maintenance EGFR tyrosine kinase inhibitors (TKIs) added to concurrent chemoradiotherapy (C

Externí odkaz: https://doaj.org/article/cc3b606db7f945f2b1fb4721c7598e52

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Genomic Profiling of Bronchoalveolar Lavage Fluid in Lung Cancer

Publikováno v: Cancer Research. 82:2838-2847

Genomic profiling of bronchoalveolar lavage (BAL) samples may be useful for tumor profiling and diagnosis in the clinic. Here, we compared tumor-derived mutations detected in BAL samples from subjects with non–small cell lung cancer (NSCLC) to thos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c40e61537ee4bd7ea6022dc01b6dc86
https://doi.org/10.1158/0008-5472.can-22-0554

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Akademický článek

Reprogramming the immunological microenvironment through radiation and targeting Axl

Autor: Todd A. Aguilera, Marjan Rafat, Laura Castellini, Hussein Shehade, Mihalis S. Kariolis, Angela Bik-Yu Hui, Henning Stehr, Rie von Eyben, Dadi Jiang, Lesley G. Ellies, Albert C. Koong, Maximilian Diehn, Erinn B. Rankin, Edward E. Graves, Amato J. Giaccia

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Radiotherapy can enhance the antitumour immune response. Here, the authors show that resistance to radiation in breast cancer cells can be due to Axl expression that suppresses antigen presentation though MHCI, promotes NF-κB signalling, and enhance

Externí odkaz: https://doaj.org/article/d32eb98fd69f4bdf897a2cd00a59903c

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