Sickle cell disease in Sri Lanka: clinical and molecular basis and the unanswered questions about disease severity

Autor: Thamal Darshana, Dayananda Bandara, Upul Nawarathne, Udaya de Silva, Yasinta Costa, Kalavitigoda Pushpakumara, Sumithra Pathirage, Seuwandi Basnayake, Chamila Epa, Pradeepa Dilrukshi, Maheshaka Wijayawardena, Angela A. Anthony, Rexan Rodrigo, Aresha Manamperi, Frances Smith, Angela Allen, Stephan Menzel, David Rees, Anuja Premawardhena

Publikováno v: Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-9 (2020)

Abstract Background Though case reports and limited case series of Sickle cell disease in Sri Lanka have been reported previously, no attempt has been made hitherto to undertake a comprehensive genotypic-phenotypic analysis of this “rare” group o

Externí odkaz: https://doaj.org/article/235f38c87dfa4b928d192bd1a390279a

Sickle cell disease in Sri Lanka: clinical and molecular basis and the unanswered questions about disease severity

Autor: Dayananda Bandara, Kalavitigoda Pushpakumara, Frances Smith, Udaya de Silva, Stephan Menzel, A. Manamperi, Pradeepa Dilrukshi, Maheshaka Wijayawardena, Anuja Premawardhena, Thamal Darshana, Rexan Rodrigo, Sumithra Pathirage, Angela A. Anthony, Upul Nawarathne, Seuwandi Basnayake, David C. Rees, Chamila Epa, Angela Allen, Yasinta Costa

Publikováno v: Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-9 (2020)
Orphanet Journal of Rare Diseases

Background Though case reports and limited case series of Sickle cell disease in Sri Lanka have been reported previously, no attempt has been made hitherto to undertake a comprehensive genotypic-phenotypic analysis of this “rare” group of patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8eb7006a0e07decfc0757f62f07646
http://link.springer.com/article/10.1186/s13023-020-01458-w

The Quinazoline Otaplimastat (SP-8203) Reduces the Hemorrhagic Transformation and Mortality Aggravated after Delayed rtPA-Induced Thrombolysis in Cerebral Ischemia

Autor: Hwa Young Song, Jee-In Chung, Angela Melinda Anthony Jalin, Chung Ju, Kisoo Pahk, Chanmin Joung, Sekwang Lee, Sejong Jin, Byoung Soo Kim, Ki Sung Lee, Jei-Man Ryu, Won-Ki Kim

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1403
International Journal of Molecular Sciences, Vol 23, Iss 1403, p 1403 (2022)

Acute ischemic stroke is the leading cause of morbidity and mortality worldwide. Recombinant tissue plasminogen activator (rtPA) is the only agent clinically approved by FDA for patients with acute ischemic stroke. However, delayed treatment of rtPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb508479457673215703746993bef284
https://doi.org/10.3390/ijms23031403

Activated Microglia Are Less Vulnerable to Hemin Toxicity due to Nitric Oxide-Dependent Inhibition of JNK and p38 MAPK Activation

Autor: Jong Hoon Ryu, Si Ling Wang, Inyoung Choi, Chung Ju, Hee Sun Kim, Woong Sun, Chan Young Shin, G. Cho, Kung Woo Nam, Ying Cai, Won Ki Kim, Angela M.A. Anthony Jalin

Publikováno v: The Journal of Immunology. 187:1314-1321

In intracerebral hemorrhage, microglia become rapidly activated and remove the deposited blood and cellular debris. To survive in a harmful hemorrhagic or posthemorrhagic condition, activated microglia must be equipped with appropriate self-defensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa55bb0762927d2a8f55166f7b942d60
https://doi.org/10.4049/jimmunol.1002925

Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols ReduceInfiltration of Microglia/Macrophages into Ischemic Brain Lesions in Ratvia Modulating 2-Arachidonolyglycerol-Induced Migration andMitochondrial Activity

Autor: Jin Sun Kwon, Angela M.A. Anthony Jalin, Chung Ju, Maheswari Rajasekaran, Yongseok Choi, Veeraswamy Gajulapati, Kisoo Pahk, Chunsook Kim, Won Ki Kim, Paul L. Prather

Publikováno v: PLOS ONE(10): 10
PLoS ONE, Vol 10, Iss 10, p e0141600 (2015)
PLoS ONE

Growing evidence suggests that therapeutic strategies to modulate the post-ischemic inflammatory responses are promising approaches to improve stroke outcome. Although the endocannabinoid system has been emerged as an endogenous therapeutic target to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4437ba58e54332c3b0529ce850e630a
http://open-repository.kisti.re.kr/cube/handle/open_repository/482470.do