Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Angela Ciuffi"'
Publikováno v:
Cells, Vol 12, Iss 23, p 2689 (2023)
Cellular composition and the responsiveness of the immune system evolve upon aging and are influenced by biological sex. CD4+ T cells from women living with HIV exhibit a decreased viral replication ex vivo compared to men’s. We, thus, hypothesized
Externí odkaz:
https://doaj.org/article/94921f04c4664331ad77c08c67edecdc
Publikováno v:
Viruses, Vol 14, Iss 8, p 1666 (2022)
Epitranscriptomics, i.e., chemical modifications of RNA molecules, has proven to be a new layer of modulation and regulation of protein expression, asking for the revisiting of some aspects of cellular biology. At the virological level, epitranscript
Externí odkaz:
https://doaj.org/article/98533e20e87d497081b5e355209aaeb4
Autor:
Monica Golumbeanu, Sara Cristinelli, Sylvie Rato, Miguel Munoz, Matthias Cavassini, Niko Beerenwinkel, Angela Ciuffi
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 942-950 (2018)
Summary: Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells. Here, w
Externí odkaz:
https://doaj.org/article/ba20726b67d54bf180515456ec3e2c08
Autor:
Curtis Dobrowolski, Saba Valadkhan, Amy C. Graham, Meenakshi Shukla, Angela Ciuffi, Amalio Telenti, Jonathan Karn
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The latent HIV reservoir is generated following HIV infection of activated effector CD4 T cells, which then transition to a memory phenotype. Here, we describe an ex vivo method, called QUECEL (quiescent effector cell latency), that mimics t
Externí odkaz:
https://doaj.org/article/541cf5d704a04c64a04abd20056f291a
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006678 (2017)
Cellular permissiveness to HIV infection is highly heterogeneous across individuals. Heterogeneity is also found across CD4+ T cells from the same individual, where only a fraction of cells gets infected. To explore the basis of permissiveness, we pe
Externí odkaz:
https://doaj.org/article/beb0efd3f9054421ad96e91456b78a5f
Publikováno v:
Journal of visualized experiments : JoVE. (181)
The role of RNA modifications in biological processes has been the focus of an increasing number of studies in the last few years and is known nowadays as epitranscriptomics. Among others, N6-methyladenosine (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8873d3c77929cb5ac999284e13b70c42
https://pubmed.ncbi.nlm.nih.gov/35311830
https://pubmed.ncbi.nlm.nih.gov/35311830
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b73a8dd27e2a944dc492585a256f1d
https://doi.org/10.3791/62426
https://doi.org/10.3791/62426
Publikováno v:
Annual Review of Virology. 7:333-350
While analyses of cell populations provide averaged information about viral infections, single-cell analyses offer individual consideration, thereby revealing a broad spectrum of diversity as well as identifying extreme phenotypes that can be exploit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aeb7251c01a2abe1dd2fde44c569f35
https://doi.org/10.1146/annurev-virology-021820-102458
https://doi.org/10.1146/annurev-virology-021820-102458
Autor:
Maxime Bellefroid, Anthony Rodari, Mathilde Galais, Peter H L Krijger, Sjoerd J D Tjalsma, Lorena Nestola, Estelle Plant, Erica S M Vos, Sara Cristinelli, Benoit Van Driessche, Caroline Vanhulle, Amina Ait-Ammar, Arsène Burny, Angela Ciuffi, Wouter de Laat, Carine Van Lint
Publikováno v:
Nucleic Acids Research, 50(6), 3190-3202. Oxford University Press
Bovine leukemia virus (BLV)-induced tumoral development is a multifactorial phenomenon that remains incompletely understood. Here, we highlight the critical role of the cellular CCCTC-binding factor (CTCF) both in the regulation of BLV transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec36449e0527a5c7ac8924d7770b392
https://pubmed.ncbi.nlm.nih.gov/35234910
https://pubmed.ncbi.nlm.nih.gov/35234910
Autor:
Angela Ciuffi, Sébastien Desfarges
Publikováno v:
Viruses, Vol 2, Iss 1, Pp 111-130 (2010)
The stable insertion of a copy of their genome into the host cell genome is an essential step of the life cycle of retroviruses. The site of viral DNA integration, mediated by the viral-encoded integrase enzyme, has important consequences for both th
Externí odkaz:
https://doaj.org/article/682f2cd7a71a4203994b145cc0ce250c