Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Angela, Wahl"'
Autor:
Jenna B. Honeycutt, Angela Wahl, Jacob K. Files, Alexis F. League, Barkha J. Yadav-Samudrala, J. Victor Garcia, Sylvia Fitting
Publikováno v:
Retrovirology, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Background Since the introduction of combination antiretroviral therapy (cART) the brain has become an important human immunodeficiency virus (HIV) reservoir due to the relatively low penetration of many drugs utilized in cART into the centr
Externí odkaz:
https://doaj.org/article/d5ece5e4edd64dc59a5cd3a175ce3050
Autor:
Lijun Ling, Manse Kim, Andrew Soper, Martina Kovarova, Rae Ann Spagnuolo, Nurjahan Begum, Jennifer Kirchherr, Nancie Archin, Diana Battaglia, Dave Cleveland, Angela Wahl, David M. Margolis, Edward P. Browne, J. Victor Garcia
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT The HIV reservoir is more dynamic than previously thought with around 70% of the latent reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral therapy (ART). In an ex vivo model system of HIV latency
Externí odkaz:
https://doaj.org/article/11242e5bc7854ce8b4f92e9d3644d4a7
Autor:
Chandrav De, Raymond J. Pickles, Wenbo Yao, Baolin Liao, Allison Boone, Rachel A. Cleary, J. Victor Garcia, Angela Wahl
Publikováno v:
Frontiers in Virology, Vol 4 (2024)
Respiratory syncytial virus (RSV) is a substantial cause of severe lower respiratory tract infections in infants, young children, older adults, and immunocompromised individuals. There is a vital need for effective therapeutics to prevent and/or trea
Externí odkaz:
https://doaj.org/article/f8b73d61273d43da90d1016db51008ed
Autor:
Lijun Ling, Chandrav De, Rae Ann Spagnuolo, Nurjahan Begum, Shane D Falcinelli, Nancie M Archin, Martina Kovarova, Guido Silvestri, Angela Wahl, David M Margolis, J Victor Garcia
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011824 (2023)
Lifelong treatment is required for people living with HIV as current antiretroviral therapy (ART) does not eradicate HIV infection. Latently infected cells are essentially indistinguishable from uninfected cells and cannot be depleted by currently av
Externí odkaz:
https://doaj.org/article/a87f849c7c8a4bcfb65f46e62f664ed6
Autor:
Angela Wahl, Lena Al-Harthi
Publikováno v:
Retrovirology, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV (PLWH), even in the era of combination antiretroviral therapy (cART). HIV-DNA can be detected in the cerebral spinal fluid (CSF) of approximately half of
Externí odkaz:
https://doaj.org/article/e977294101274354aead53069d99b555
An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity
Autor:
Kathryn L. Roche, Stacy Remiszewski, Matthew J. Todd, John L. Kulp III, Liudi Tang, Alison V. Welsh, Ashley P. Barry, Chandrav De, William W. Reiley, Angela Wahl, J. Victor Garcia, Micah A. Luftig, Thomas Shenk, James R. Tonra, Eain A. Murphy, Lillian W. Chiang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Most drugs used to treat viral disease target a virus-coded product. They inhibit a single virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals can overcome these limitations. The broad-spectrum activity ach
Externí odkaz:
https://doaj.org/article/aae26d7a4a0143a6b97410639780fe44
Autor:
Chandrav De, Raymond J. Pickles, Wenbo Yao, Baolin Liao, Allison Boone, Mingyu Choi, Diana M. Battaglia, Frederic B. Askin, Jason K. Whitmire, Guido Silvestri, J. Victor Garcia, Angela Wahl
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Respiratory syncytial virus (RSV) infection causes significant morbidity and mortality in infants, immunocompromised individuals, and older individuals. There is an urgent need for effective antivirals and vaccines for high-risk individuals. We used
Externí odkaz:
https://doaj.org/article/c0bb5fe856ad4faeb51045c5fbd7169b
Autor:
Manse Kim, Claire E. Johnson, Alan A. Schmalstig, Ayano Annis, Sarah E. Wessel, Brian Van Horn, Amanda Schauer, Agata A. Exner, Jason E. Stout, Angela Wahl, Miriam Braunstein, J. Victor Garcia, Martina Kovarova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Non-adherence to anti-tubercular therapy Mycobacterium tuberculosis infection can lead to treatment failure and even the development of drug resistance. In this work, the authors develop a long-acting delivery system of the anti-tuberculosis drug rif
Externí odkaz:
https://doaj.org/article/78ca0bb18972453d8ccd4f196de8996e
Autor:
Lijun Ling, Ana R. Leda, Nurjahan Begum, Rae Ann Spagnuolo, Angela Wahl, J. Victor Garcia, Susana T. Valente
Publikováno v:
Viruses, Vol 15, Iss 4, p 950 (2023)
HIV resistance to the Tat inhibitor didehydro-cortistatin A (dCA) in vitro correlates with higher levels of Tat-independent viral transcription and a seeming inability to enter latency, which rendered resistant isolates more susceptible to CTL-mediat
Externí odkaz:
https://doaj.org/article/3c292db9c9e04774aacfab1e3bec23ba
Autor:
Christopher B. Whitehurst, Monica Rizk, Adonay Teklezghi, Rae Ann Spagnuolo, Joseph S. Pagano, Angela Wahl
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
In most individuals, EBV maintains a life-long asymptomatic latent infection. However, EBV can induce the formation of B cell lymphomas in immune suppressed individuals including people living with HIV (PLWH). Most individuals who acquire HIV are alr
Externí odkaz:
https://doaj.org/article/3c1012fa9ba242cd819283ed51496330