Výsledky vyhledávání - "Angela, McHugh"

Akademický článek

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous

Externí odkaz: https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a

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Periodical

STUDIO VISIT.

Publikováno v: Art Edit; 2023, Issue 38, p88-93, 6p

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The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma

Autor: Nerime Chinner, Adel F. M. Ibrahim, Irene M. Leigh, Amit K. Garg, Mark K. Saville, Charlotte M. Proby, Lydia A. Hepburn, Angela McHugh, Garry Boag, Kenneth Fernandes

Publikováno v: The Journal of Investigative Dermatology

We performed a small interfering RNA screen to identify targets for cutaneous squamous cell carcinoma (cSCC) therapy in the ubiquitin/ubiquitin-like system. We provide evidence for selective anti-cSCC activity of knockdown of the E3 ubiquitin ligase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e8e131946dc974aa7c027499a63206
https://pubmed.ncbi.nlm.nih.gov/31705877

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Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Autor: Lydia A, Hepburn, Angela, McHugh, Kenneth, Fernandes, Garry, Boag, Charlotte M, Proby, Irene M, Leigh, Mark K, Saville

Publikováno v: Oncotarget

We show that suppression of the spliceosome has potential for the treatment of cutaneous squamous cell carcinoma (cSCC). The small-molecule inhibitors of the spliceosome at the most advanced stage of development target the splicing factor SF3B1/SF3b1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94da23a18ea0571cc08f705e5ad513c7
https://pubmed.ncbi.nlm.nih.gov/29796170

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Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation

Autor: Sarah T. Arron, Jasbani H.S. Dayal, Angela McHugh, Andrew P. South, Catherine A. Harwood, Nicoline Y. den Breems, Dylan J. Xue, Irene M. Leigh, Charlotte M. Proby, Stephen Watt, Karin J. Purdie, Michelle Dimon

Publikováno v: The American Journal of Pathology. 185:2354-2363

NF-κB signaling plays a crucial role in regulating proliferation and differentiation in the epidermis. Alterations in the NF-κB pathway can lead to skin pathologies with a significant burden to human health such as psoriasis and cutaneous squamous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d243fe4ea8f7db04a514894a01e0284
https://doi.org/10.1016/j.ajpath.2015.05.018

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Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity

Autor: Angela, McHugh, Kenneth, Fernandes, Andrew P, South, Jemima E, Mellerio, Julio C, Salas-Alanís, Charlotte M, Proby, Irene M, Leigh, Mark K, Saville

Publikováno v: Oncotarget

Proteasome inhibitors have distinct properties and the biochemical consequences of suppressing ubiquitin E1 enzymes and the proteasome differ. We compared the effects of the proteasome inhibitors bortezomib, ixazomib and carfilzomib and the ubiquitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::337ae485a02210f2029c9b68b854fd8d
https://pubmed.ncbi.nlm.nih.gov/29755650

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NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

Autor: Irene M. Leigh, Michael J. Kluk, Nicoline Y. den Breems, Kim S. Robinson, Charlotte M. Proby, Andrew P. South, Catherine A. Harwood, Jon C. Aster, Michelle Dimon, Angela McHugh, Sam Haldenby, Jasbani H.S. Dayal, Karin J. Purdie, S.M. Hasan Rizvi, Sarah T. Arron, Dylan J. Xue, Stephen Watt

Publikováno v: The Journal of investigative dermatology

Cutaneous SCC (cSCC) is the most frequently occuring skin cancer with metastatic potential and can manifest rapidly as a common side effect in patients receiving systemic kinase inhibitors. Here, we use massively parallel exome and targeted level seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f04c192d6f75ec1577a2df7e158a31
http://europepmc.org/articles/PMC4753672

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Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Publikováno v: Cammareri, P, Rose, A M, Vincent, D F, Wang, J, Nagano, A, Libertini, S, Ridgway, R A, Athineos, D, Coates, P J, McHugh, A, Pourreyron, C, Dayal, J H S, Larsson, J, Weidlich, S, Spender, L C, Sapkota, G P, Purdie, K J, Proby, C M, Harwood, C A, Leigh, I M, Clevers, H, Barker, N, Karlsson, S, Pritchard, C, Marais, R, Chelala, C, South, A P, Sansom, O J & Inman, G J 2016, ' Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma ', Nature Communications, vol. 7, 12493 . https://doi.org/10.1038/ncomms12493
Nature Communications, 7. Nature Publishing Group
Nature Communications [E], 7. Nature Publishing Group
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications

Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK pathway activation. Here we identify frequent TGFBR1 and TGFBR2 mutations in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3436b88b2c09034682df9ba1b22d0f5
https://www.research.manchester.ac.uk/portal/en/publications/inactivation-of-tgf-receptors-in-stem-cells-drives-cutaneous-squamous-cell-carcinoma(dbbe84d0-3ec2-4c50-a957-399731e49e6f).html

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