Výsledky vyhledávání - "Angela, Mastronuzzi"

Akademický článek

The coexistence of a BRCA2 germline and a DICER1 somatic variant in two first-degree cousins suggests their potential synergic effect

Autor: Giada Del Baldo, Angela Mastronuzzi, Selene Cipri, Emanuele Agolini, Marta Matraxia, Antonio Novelli, Antonella Cacchione, Annalisa Serra, Andrea Carai, Luigi Boccuto, Giovanna Stefania Colafati, Pier Luigi Di Paolo, Evelina Miele, Sabina Barresi, Rita Alaggio, Sabrina Rossi, Isabella Giovannoni

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Cancer predisposition syndromes are recognized in about 10% of pediatric malignancies with several genes specifically involved in a subset of pediatric tumors such as DICER1, in pleuropulmonary blastoma, cystic nephroma, and brain sarcomas.

Externí odkaz: https://doaj.org/article/6e9544ccf65a442488bd95429b65a943

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Akademický článek

Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling

Autor: Lucia Pedace, Simone Pizzi, Luana Abballe, Maria Vinci, Celeste Antonacci, Sara Patrizi, Claudia Nardini, Francesca Del Bufalo, Sabrina Rossi, Giulia Pericoli, Francesca Gianno, Zein Mersini Besharat, Luca Tiberi, Angela Mastronuzzi, Elisabetta Ferretti, Marco Tartaglia, Franco Locatelli, Andrea Ciolfi, Evelina Miele

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)

Abstract In vitro models of pediatric brain tumors (pBT) are instrumental for better understanding the mechanisms contributing to oncogenesis and testing new therapies; thus, ideally, they should recapitulate the original tumor. We applied DNA methyl

Externí odkaz: https://doaj.org/article/3e271e6514f4435baadb82be0810cbf5

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Akademický článek

Humoral and cellular immune response after mRNA SARS-CoV-2 vaccine in children on treatment for cancer: A pilot observational study

Publikováno v: Heliyon, Vol 10, Iss 14, Pp e34503- (2024)

Immunocompromised children are at risk of developing severe COVID-19 infection. We conducted a pilot prospective study to evaluate the impact of cancer treatment and stem cell transplantation on immunogenicity of two doses of BNT162b2 vaccine in pedi

Externí odkaz: https://doaj.org/article/b4ccc5b9eef748c8bf7b9a17079caa56

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Akademický článek

Malignant peripheral nerve sheath tumor (MPNST) and MPNST-like entities are defined by a specific DNA methylation profile in pediatric and juvenile population

Publikováno v: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)

Abstract Background Malignant peripheral nerve sheath tumors (MPNSTs) account for 3–10% of pediatric sarcomas, 50% of which occur in neurofibromatosis type 1 (NF1). Sporadic MPNSTs diagnosis may be challenging due to the absence of specific markers

Externí odkaz: https://doaj.org/article/e153def98c9c43fea6e3e57bc6160250

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Akademický článek

Pediatric CNS tumors and 2021 WHO classification: what do oncologists need from pathologists?

Publikováno v: Frontiers in Molecular Neuroscience, Vol 17 (2024)

The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, established new approaches to both CNS tumor nomenclature and grading, emphasizing the importance of integrated diagnoses and layered report

Externí odkaz: https://doaj.org/article/d304074ec20344c6b7696081fd8ca6fc

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Akademický článek

Venetoclax plus cyclophosphamide and topotecan in heavily pre-treated relapsed metastatic neuroblastoma: a single center case series

Autor: Maria Antonietta De Ioris, Francesco Fabozzi, Francesca Del Bufalo, Giada Del Baldo, Maria Felicia Villani, Maria Giuseppina Cefalo, Maria Carmen Garganese, Alessandra Stracuzzi, Federica Tangari, Arturo Maria Greco, Isabella Giovannoni, Roberto Carta, Maria Luisa D’Andrea, Angela Mastronuzzi, Franco Locatelli

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-5 (2023)

Abstract The prognosis of relapsed/refractory (R/R) neuroblastoma (NB) is dismal, calling for new therapeutic strategies. Venetoclax (VEN) is a highly selective, potent, orally bioavailable, BCL-2 inhibitor small-molecule that showed a synergistic ef

Externí odkaz: https://doaj.org/article/d9a3f4ab567b4cb2b052b48621dda13d

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Akademický článek

Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments

Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-28 (2023)

Abstract Brain tumors are the leading cause of cancer‐related death in children. Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of pediatric brain cancers are limited and hard to establish. We present a p

Externí odkaz: https://doaj.org/article/27709dc824264046a65fac5ef01127a4

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Akademický článek

Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas

Publikováno v: Cell & Bioscience, Vol 13, Iss 1, Pp 1-24 (2023)

Abstract Background Paediatric-type diffuse High-Grade Gliomas (PDHGG) are highly heterogeneous tumours which include distinct cell sub-populations co-existing within the same tumour mass. We have previously shown that primary patient-derived and opt

Externí odkaz: https://doaj.org/article/d7785bfb848a4134a77dbd73c0fde68b

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