Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Angela, Hussainkhel"'
Autor:
JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield
Publikováno v:
eLife, Vol 11 (2022)
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G
Externí odkaz:
https://doaj.org/article/ff1c4ccf767e411f85c1b12a0db8fe55
Autor:
Patrick Coulombe, Grigorios N. Paliouras, Ashley Clayton, Angela Hussainkhel, Megan Fuller, Vida Jovanovic, Shauna Dauphinee, Patricia Umlandt, Ping Xiang, Alistair H. Kyle, Andrew I. Minchinton, R. Keith Humphries, Pamela A. Hoodless, Jeremy D.K. Parker, Joanne L. Wright, Aly Karsan
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1769-1780.e4 (2019)
Summary: The sterile alpha motif (SAM) and SRC homology 3 (SH3) domain containing protein 1 (Sash1) acts as a scaffold in TLR4 signaling. We generated Sash1−/− mice, which die in the perinatal period due to respiratory distress. Constitutive or e
Externí odkaz:
https://doaj.org/article/7da597faf600423285c07b09a097bc00
Autor:
Sultan Chowdhury, David Bogucki, Rostam Namdari, Girish Bankar, Wei Zhang, James Roy Empfield, Matthew Waldbrook, Stephanie M Lee, Lofstrand Verner Alexander, Karen Nelkenbrecher, Samuel J. Goodchild, Rhena Yoo, Noah G. Shuart, Wesolowski Steven Sigmund, Elaine Chang, Mandy Feng, Clint Young, Christoph Martin Dehnhardt, Jenny Li, Zhiwei Xie, Michael Edward Grimwood, Abid Hasan, Sophia Lin, Kristen Burford, Raymond J. Winquist, Charles J. Cohen, Alla Yurevna Zenova, Simon N. Pimstone, Michael R. Wilson, Parisa Karimi Tari, Kuldip Khakh, Celine Dube, Aaron M. Williams, Robin Sherrington, Luis Sojo, Andrea Lindgren, J. P. Johnson, Thilo Focken, Qi Jia, Jean-Christophe Andrez, Shannon Decker, Matthew Taron, Diana Weeratunge, Richard T. Dean, Janette Mezeyova, Shaoyi Sun, Wei Gong, Angela Hussainkhel, Gina de Boer, Alison Jane Cutts
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32e2e6674136369f3abcd5070b52e762
https://doi.org/10.1101/2021.08.29.458125
https://doi.org/10.1101/2021.08.29.458125
Autor:
J P, Johnson, Thilo, Focken, Kuldip, Khakh, Parisa Karimi, Tari, Celine, Dube, Samuel J, Goodchild, Jean-Christophe, Andrez, Girish, Bankar, David, Bogucki, Kristen, Burford, Elaine, Chang, Sultan, Chowdhury, Richard, Dean, Gina, de Boer, Shannon, Decker, Christoph, Dehnhardt, Mandy, Feng, Wei, Gong, Michael, Grimwood, Abid, Hasan, Angela, Hussainkhel, Qi, Jia, Stephanie, Lee, Jenny, Li, Sophia, Lin, Andrea, Lindgren, Verner, Lofstrand, Janette, Mezeyova, Rostam, Namdari, Karen, Nelkenbrecher, Noah Gregory, Shuart, Luis, Sojo, Shaoyi, Sun, Matthew, Taron, Matthew, Waldbrook, Diana, Weeratunge, Steven, Wesolowski, Aaron, Williams, Michael, Wilson, Zhiwei, Xie, Rhena, Yoo, Clint, Young, Alla, Zenova, Wei, Zhang, Alison J, Cutts, Robin P, Sherrington, Simon N, Pimstone, Raymond, Winquist, Charles J, Cohen, James R, Empfield
Publikováno v:
eLife. 11
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3cf389ce4c308fb570995099c2f50504
https://pubmed.ncbi.nlm.nih.gov/35234610
https://pubmed.ncbi.nlm.nih.gov/35234610
Autor:
Shaoyi, Sun, Qi, Jia, Alla Y, Zenova, Sophia, Lin, Angela, Hussainkhel, Janette, Mezeyova, Elaine, Chang, Samuel J, Goodchild, Zhiwei, Xie, Andrea, Lindgren, Gina, de Boer, Rainbow, Kwan, Kuldip, Khakh, Luis, Sojo, Paul, Bichler, J P, Johnson, James R, Empfield, Charles J, Cohen, Christoph M, Dehnhardt, Richard, Dean
Publikováno v:
Bioorganicmedicinal chemistry letters. 45
We describe the synthesis and biological evaluation of a series of novel aryl sulfonamides that exhibit potent inhibition of Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72ffd93fb821803255bea0175c7110a5
https://pubmed.ncbi.nlm.nih.gov/34044121
https://pubmed.ncbi.nlm.nih.gov/34044121
Autor:
Aly Karsan, Patrick Coulombe, Patricia Umlandt, Ashley Clayton, Shauna M. Dauphinee, Joanne L. Wright, Pamela A. Hoodless, Jeremy Parker, Megan Fuller, Ping Xiang, Andrew I. Minchinton, Vida Jovanovic, Grigorios Paliouras, R. Keith Humphries, Alistair H. Kyle, Angela Hussainkhel
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1769-1780.e4 (2019)
Summary: The sterile alpha motif (SAM) and SRC homology 3 (SH3) domain containing protein 1 (Sash1) acts as a scaffold in TLR4 signaling. We generated Sash1−/− mice, which die in the perinatal period due to respiratory distress. Constitutive or e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11836e29b96882183f3f5885ef83511f
https://pubmed.ncbi.nlm.nih.gov/31067462
https://pubmed.ncbi.nlm.nih.gov/31067462
Autor:
Yoo Jin Park, Ashley Clayton, Angela Hussainkhel, Josip Blonder, Cindy Yang, Shauna M. Dauphinee, Timothy D. Veenstra, Megan Fuller, Aly Karsan
Publikováno v:
The Journal of Immunology. 191:892-901
Recognition of microbial products by TLRs is critical for mediating innate immune responses to invading pathogens. In this study, we identify a novel scaffold protein in TLR4 signaling called SAM and SH3 domain containing protein 1 (SASH1). Sash1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cbbbb48dabe084b71fc15091fec7f6
https://doi.org/10.4049/jimmunol.1200583
https://doi.org/10.4049/jimmunol.1200583
Autor:
Baljit Kamoh, Malachi Griffith, Donglei Hu, Annaick Carles, Michael T. McManus, Yussanne Ma, Mahvash Sigaroudinia, Jeffrey B. Cheng, Dorothy Cheung, Luolan Li, Patrick Plettner, Angela Hussainkhel, Joseph F. Costello, Philippe Gascard, Matthew Mingay, Steven J.M. Jones, Jianxin Zhao, Irene Li, Chibo Hong, Alireza Heravi-Moussavi, Peggy J. Farnham, Richard A. Moore, Brad Davis, Andy Chu, Angela Tam, Allen Delaney, Gordon Robertson, Andrew J. Mungall, Matthew J. Hangauer, Lorigail Echipare, Thea D. Tlsty, Martin Hirst, Elad Ziv, Ting Wang, Misha Bilenky, Raman P. Nagarajan, Marco A. Marra, Dana S. Neel, Henriette O'Geen, Michelle Moksa, Stephanie Cho
Publikováno v:
Nature Communications
While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known about the epigenetic changes that accompany post-natal differentiation where fully function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf7814f3ef4d20fc3c3c770e0dc0ccf
https://doi.org/10.1038/ncomms7351
https://doi.org/10.1038/ncomms7351
Autor:
Jinkyo Suh, Jennifer M Grants, Angela Hussainkhel, Andreas Steimel, Richard Zapf, Samineh Deheshi, Stefan Taubert, Harald Hutter, Donald G. Moerman
Publikováno v:
Developmental biology. 377(2)
Receptors expressed on the growth cone of outgrowing axons detect cues required for proper navigation. The pathway choices available to an axon are in part defined by the set of guidance receptors present on the growth cone. Regulated expression of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8c7681a145cd648fa21007c69cb9b8
https://pubmed.ncbi.nlm.nih.gov/23458898
https://pubmed.ncbi.nlm.nih.gov/23458898