Zobrazeno 1 - 10 of 244 pro vyhledávání: '"Angela, Fago"'
1
Akademický článek
The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM
Autor: Katsuya Takahashi, Yongchan Lee, Angela Fago, Naim M. Bautista, Jay F. Storz, Akihiro Kawamoto, Genji Kurisu, Tomohiro Nishizawa, Jeremy R. H. Tame
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The principal effect controlling the oxygen affinity of vertebrate haemoglobins (Hbs) is the allosteric switch between R and T forms with relatively high and low oxygen affinity respectively. Uniquely among jawed vertebrates, crocodilians po
Externí odkaz: https://doaj.org/article/33c62f75f40140c081470ffac962c7cb
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3
Akademický článek
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows
Autor: Anthony V Signore, Phillip R Morrison, Colin J Brauner, Angela Fago, Roy E Weber, Kevin L Campbell
Publikováno v: eLife, Vol 12 (2023)
The extinct Steller’s sea cow (Hydrodamalis gigas; †1768) was a whale-sized marine mammal that manifested profound morphological specializations to exploit the harsh coastal climate of the North Pacific. Yet despite first-hand accounts of their b
Externí odkaz: https://doaj.org/article/9064cfac40364a85829042713f263289
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4
Akademický článek
Structural and oxidative investigation of a recombinant high-yielding fetal hemoglobin mutant
Autor: Karin Kettisen, Maria Nyblom, Emanuel Smeds, Angela Fago, Leif Bülow
Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)
Human fetal hemoglobin (HbF) is an attractive starting protein for developing an effective agent for oxygen therapeutics applications. This requires that HbF can be produced in heterologous systems at high levels and in a homogeneous form. The introd
Externí odkaz: https://doaj.org/article/db916bc918174a538d54a6e486373c90
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5
Akademický článek
Intrinsic Mechanisms Underlying Hypoxia-Tolerant Mitochondrial Phenotype During Hypoxia-Reoxygenation Stress in a Marine Facultative Anaerobe, the Blue Mussel Mytilus edulis
Autor: Eugene P. Sokolov, Linda Adzigbli, Stephanie Markert, Amanda Bundgaard, Angela Fago, Dörte Becher, Claudia Hirschfeld, Inna M. Sokolova
Publikováno v: Frontiers in Marine Science, Vol 8 (2021)
Hypoxia is common in marine environments and a major stressor for marine organisms inhabiting benthic and intertidal zones. Several studies have explored the responses of these organisms to hypoxic stress at the whole organism level with a focus on e
Externí odkaz: https://doaj.org/article/833ae66eacfc4998bd005a97becdceac
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6
Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts
Autor: Amanda Bundgaard, Anja V. Gruszczyk, Hiran A. Prag, Catherine Williams, Angela McIntyre, Ilan M. Ruhr, Andrew M. James, Gina L. J. Galli, Michael P. Murphy, Angela Fago
Publikováno v: Bundgaard, A, Gruszczyk, A V, Prag, H A, Williams, C, McIntyre, A, Ruhr, I M, James, A M, Galli, G L J, Murphy, M P & Fago, A 2023, ' Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts ', The Journal of Experimental Biology, vol. 226, no. 9 . https://doi.org/10.1242/jeb.245516
Bundgaard, A, Gruszczyk, A V, Prag, H A, Williams, C, Mcintyre, A, Ruhr, I M, James, A M, Galli, G L J, Murphy, M P & Fago, A 2023, ' Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts ', Journal of Experimental Biology . https://doi.org/10.1242/jeb.245516
Extremely anoxia-tolerant animals, such as freshwater turtles, survive anoxia and reoxygenation without sustaining tissue damage to their hearts. In contrast, for mammals, the ischemia–reperfusion (IR) injury that leads to tissue damage during a he
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c0edc677451afec622f62c3bad67c6
https://pure.au.dk/portal/da/publications/low-production-of-mitochondrial-reactive-oxygen-species-after-anoxia-and-reoxygenation-in-turtle-hearts(217cb115-7d77-48fe-b655-49415632821a).html
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7
Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin
Autor: Chandrasekhar Natarajan, Anthony V. Signore, Naim M. Bautista, Federico G. Hoffmann, Jeremy R. H. Tame, Angela Fago, Jay F. Storz
Publikováno v: Natarajan, C, Signore, A V, M. Bautista, N, Hoffmann, F G, Tame, J R H, Fago, A & Storz, J F 2023, ' Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin ', Current Biology, vol. 33, no. 1, pp. 98-108.e4 . https://doi.org/10.1016/j.cub.2022.11.049
Understanding the evolution of novel protein functions requires data on the mechanistic effects of causative mutations and the extent of coupling between the gain of new function and loss of ancestral function. Here, we use ancestral protein resurrec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1137392177294b0741819d8588aa5da0
https://pure.au.dk/portal/da/publications/evolution-and-molecular-basis-of-a-novel-allosteric-property-of-crocodilian-hemoglobin(ee444a43-d9e4-426b-a175-7e890e1b1673).html
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8
Akademický článek
Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose.
Autor: Chandrasekhar Natarajan, Agnieszka Jendroszek, Amit Kumar, Roy E Weber, Jeremy R H Tame, Angela Fago, Jay F Storz
Publikováno v: PLoS Genetics, Vol 14, Iss 4, p e1007331 (2018)
During the adaptive evolution of a particular trait, some selectively fixed mutations may be directly causative and others may be purely compensatory. The relative contribution of these two classes of mutation to adaptive phenotypic evolution depends
Externí odkaz: https://doaj.org/article/e1779528ddcd417a9902f6bfbd26d3b0
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9
Akademický článek
The Greenland shark Somniosus microcephalus-Hemoglobins and ligand-binding properties.
Autor: Roberta Russo, Daniela Giordano, Gianluca Paredi, Francesco Marchesani, Lisa Milazzo, Giovanna Altomonte, Pietro Del Canale, Stefania Abbruzzetti, Paolo Ascenzi, Guido di Prisco, Cristiano Viappiani, Angela Fago, Stefano Bruno, Giulietta Smulevich, Cinzia Verde
Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0186181 (2017)
A large amount of data is currently available on the adaptive mechanisms of polar bony fish hemoglobins, but structural information on those of cartilaginous species is scarce. This study presents the first characterisation of the hemoglobin system o
Externí odkaz: https://doaj.org/article/a91549d51c924dcc9307e1cfce37bd85
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10
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows
Autor: Anthony V. Signore, Phillip R. Morrison, Colin J. Brauner, Angela Fago, Roy E. Weber, Kevin L. Campbell
Publikováno v: Signori, A V, Morrison, P R, Brauner, C J, Fago, A, Weber, R E & Campbell, K L 2023, ' Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller's sea cows ', eLife, vol. in press .
The extinct Steller’s sea cow (Hydrodamalis gigas; †1768) was a whale-sized marine mammal that manifested profound morphological specializations to exploit the harsh coastal climate of the North Pacific. Yet despite first-hand accounts of their b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3feed46da681bc762fb4b3a99c11d000
https://doi.org/10.1101/2022.08.29.505768
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