Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity

Autor: Valentina Salvi, Carolina Gaudenzi, Barbara Mariotti, Gaia Giongrandi, Silvia Alacqua, Veronica Gianello, Tiziana Schioppa, Laura Tiberio, Angela Ceribelli, Carlo Selmi, Paolo Bergese, Stefano Calza, Annalisa Del Prete, Silvano Sozzani, Flavia Bazzoni, Daniela Bosisio

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)

Abstract Background The physiological relevance of cell-to-cell communication mediated by small extracellular vesicle-encapsulated microRNAs (sEV-miRNAs) remains debated because of the limiting representativity of specific miRNAs within the extracell

Externí odkaz: https://doaj.org/article/314b902687d6416e8812b09c4914d5db

Autoantibodies, cutaneous subset and immunosuppressants contribute to the cancer risk in systemic sclerosis

Autor: Maria De Santis, Carlo Selmi, Angela Ceribelli, Stefanos Bonovas, Francesca Motta, Antonio Tonutti, Natasa Isailovic, Rita Ragusa, Emanuele Nappi

Publikováno v: RMD Open, Vol 10, Iss 3 (2024)

Objective Systemic sclerosis (SSc) is associated with an increased risk of cancer. We aimed to assess the prevalence of cancer in our cohort and to explore possible associations with clinical, immunological and treatment characteristics.Methods Our r

Externí odkaz: https://doaj.org/article/6ebc8d8768d04041b9fac8a561e4652e

Proteomic aptamer analysis reveals serum biomarkers associated with disease mechanisms and phenotypes of systemic sclerosis

Autor: Francesca Motta, Antonio Tonutti, Natasa Isailovic, Angela Ceribelli, Giovanni Costanzo, Stefano Rodolfi, Carlo Selmi, Maria De Santis

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundSystemic sclerosis (SSc) is an autoimmune connective tissue disease that affects multiple organs, leading to elevated morbidity and mortality with limited treatment options. The early detection of organ involvement is challenging as there i

Externí odkaz: https://doaj.org/article/c2c80fc4ed634906bcd0c0424d68e8e4

Interstitial lung disease associated with inflammatory myositis: Autoantibodies, clinical phenotypes, and progressive fibrosis

Autor: Angela Ceribelli, Antonio Tonutti, Natasa Isailovic, Maria De Santis, Carlo Selmi

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

Progressive pulmonary fibrosis is generally diagnosed when interstitial lung disease progression occurs in the absence of any other cause, and a subset of patients with myositis and associated interstitial lung disease may develop progressive pulmona

Externí odkaz: https://doaj.org/article/9c00eb199afb40f79c228b166f1e7899

Neutralizing antibodies to Omicron after the fourth SARS-CoV-2 mRNA vaccine dose in immunocompromised patients highlight the need of additional boosters

Autor: Maria Rescigno, Chiara Agrati, Carlo Salvarani, Diana Giannarelli, Massimo Costantini, Alberto Mantovani, Raffaella Massafra, Pier Luigi Zinzani, Aldo Morrone, Stefania Notari, Giulia Matusali, Giuseppe Lauria Pinter, Antonio Uccelli, Gennaro Ciliberto, Fausto Baldanti, Franco Locatelli, Nicola Silvestris, Valentina Sinno, Elena Turola, Maria Teresa Lupo-Stanghellini, Giovanni Apolone, the VAX4FRAIL study Group, Fabio Ciceri, Massimo Tommasino, Giuseppe Lauri Pinter, Paolo Corradini, Daniela Fenoglio, Roberta Mortarini, Laura Conti, Chiara Mandoj, Michela Lizier, Stefania Croci, Vito Garrisi, Fulvio Baggi, Tiziana Lazzarotto, Francesca Bonifazi, Concetta Quintarelli, Rita Carsetti, Enrico Girardi, Aurora Bettini, Veronica Bordoni, Concetta Castilletti, Eleonora Cimini, Rita Casetti, Francesca Colavita, Flavia Cristofanelli, Massimo Francalancia, Simona Gili, Delia Goletti, Giulia Gramigna, Germana Grassi, Daniele Lapa, Sara Leone, Davide Mariotti, Silvia Meschi, Enzo Puro, Marika Rubino, Alessandra Sacchi, Eleonora Tartaglia, Silvia Damian, Vincenzo Marasco, Filippo de Braud, Maria Teresa Lupo Stanghellini, Lorenzo Dagna, Francesca Ogliari, Massimo Filippi, Alessandro Bruno, Gloria Catalano, Rosamaria Nitti, Andrea Mengarelli, Francesco Marchesi, Giancarlo Paoletti e Gabriele Minuti, Elena Papa, Elena Azzolini, Luca Germagnoli, Carlo Selmi, Maria De Santis, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Chiara Miggiano, Giulia Fornasa, Sara Monti, Carlo Maurizio Montecucco, Dario Graceffa, Maria Grazia Catanoso, Monica Guberti, Carmine Pinto, Francesco Merli, Franco Valzania, Rosa Divella, Antonio Tufaro, Sabina Delcuratolo, Mariana Miano, Carlo Antozzi, Silvia Bonanno Rita Frangiamore, Lorenzo Maggi, Paolo Pronzato, Matilde Inglese, Carlo Genova, Caterina Lapucci, Alice Laroni, Ilaria Poiré, Marco Fusconi, Vittorio Stefoni, Maria Abbondanza Pantaleo, Serena Di Cosimo, Iolanda Pulice, Roberta Mennitto Fondazione, Stefania Trinca, Giulia Piaggio, Chiara Pozzi, Irene Cassaniti, Alessandro Barberini, Rinaldi Elena, Federica Bortone, Maria Giovanna Dal Bello, Silvia Corazza

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionImmunocompromised patients have been shown to have an impaired immune response to COVID-19 vaccines.MethodsHere we compared the B-cell, T-cell and neutralizing antibody response to WT and Omicron BA.2 SARS-CoV-2 virus after the fourth dos

Externí odkaz: https://doaj.org/article/a00ef900915647aea19566921473db22