Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Angel Wai-mun Lee"'
Autor:
Attila Szabo, Boi Hanh Huynh, David A. Case, Martin Karplus, Angel Wai-mun Lee, Bruce R. Gelin
Hemoglobin, because of its vital role in oxygen transport and its status as a model for cooperative proteins, has been the subject of a wide range of physical and chemical studies for many years. This chapter presents a brief introduction to the ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d60616ab60a25eb51d243241a597a259
https://doi.org/10.1201/9781003068563-2
https://doi.org/10.1201/9781003068563-2
Autor:
Angel Wai-mun Lee
Publikováno v:
Blood. 93:537-553
Colony-stimulating factors (CSFs) promote the proliferation, differentiation, commitment, and survival of myeloid progenitors, whereas cyclic AMP (cAMP)-mediated signals frequently induce their growth arrest and apoptosis. The ERK/mitogen-activated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c500a05fcaed35dd8b6a9a2fc4e22dfb
https://doi.org/10.1182/blood.v93.2.537
https://doi.org/10.1182/blood.v93.2.537
Publikováno v:
Oncogene. 18(52)
The CSF-1 receptor (CSF-1R) is expressed in >50% of human breast cancers. To investigate the consequence of CSF-1R expression, hormone-dependent human breast cancer cell lines, MCF-7 and T-47D, were transfected with CSF-1R. Unexpectedly, CSF-1 substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a341673a15e43a590d194d56e8ce5c5
https://pubmed.ncbi.nlm.nih.gov/10602507
https://pubmed.ncbi.nlm.nih.gov/10602507
Autor:
Angel Wai-Mun Lee
Publisher Summary The colony-stimulating factor-1 (CSF-1) receptor (CSF-1R), encoded by the protooncogene c- fms , is the cell surface receptor for the macrophage colony-stimulating factor. It is a member of the tyrosine kinase family of growth facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc2412288e28ed811bdd4b7a88866b59
https://doi.org/10.1016/b978-0-12-152832-4.50005-7
https://doi.org/10.1016/b978-0-12-152832-4.50005-7
Autor:
Angel Wai-Mun Lee, Arthur W. Nienhuis
Receptor tyrosine kinases remain dormant until activated by ligand binding to the extracellular domain. Two mechanisms have been proposed for kinase activation: (i) ligand binding to the external domain of a receptor monomer may induce a conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2822b0ab0e9eac668ac088121566c9af
https://europepmc.org/articles/PMC54725/
https://europepmc.org/articles/PMC54725/
Publikováno v:
Biochemistry. 27:1285-1301
The relationship in hemoglobin between cooperativity (dependence of the Hill constant on pH0 and the Bohr effect (dependence of the mean oxygen affinity on pH) can be described by a statistical thermodynamic model [Szabo, A., & Karplus, M. (1972) J.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4eb348ead427a54054065250295bc32
https://doi.org/10.1021/bi00404a031
https://doi.org/10.1021/bi00404a031
Publikováno v:
Journal of Molecular Biology. 171:489-559
Analysis of the tertiary structural alterations in hemoglobin induced by ligand binding demonstrates that an allosteric core composed of the heme, histidine F8, the FG corner and part of the F-helix plays an essential role in co-operativity. This con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06123eaf2891510e4e4e27137424e720
https://doi.org/10.1016/0022-2836(83)90042-6
https://doi.org/10.1016/0022-2836(83)90042-6