Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Angel T Som"'
Autor:
Shuzhen Guo, Yiming Zhou, Changhong Xing, Josephine Lok, Angel T Som, MingMing Ning, Xunming Ji, Eng H Lo
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52665 (2012)
The blood vessel is no longer viewed as passive plumbing for the brain. Increasingly, experimental and clinical findings suggest that cerebral endothelium may possess endocrine and paracrine properties - actively releasing signals into and receiving
Externí odkaz:
https://doaj.org/article/98e99d01e1ec406487e245012ccaad43
Publikováno v:
Brain Res
Angiotensin-II (Ang-II) is a key factor in hypertension, diabetes and aging, which are all primary risk factors for CNS disease. Furthermore, Ang-II may play under- appreciated roles in neurogenesis, angiogenesis and CNS remodeling. Therefore, any co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e474ed96809560244ae0c82fe1a2e8
https://europepmc.org/articles/PMC6755037/
https://europepmc.org/articles/PMC6755037/
Autor:
Aurauma Chutinet, Tijy Thankachan, Steven K. Feske, Natalia S. Rost, Muhib Khan, Eng H. Lo, Paul E. Milbury, Gordon J. Harris, Ken Arai, Alona Muzikansky, Svetlana Lorenzano, Rebecca E. Green, Jeffrey B. Blumberg, Hua Li, Leonardo M. Batista, Loc-Duyen D. Pham, Karen L. Furie, Ona Wu, Brenda Thornell, Angel T. Som
Publikováno v:
Neurology
ObjectivesTo assess whether plasma biomarkers of oxidative stress predict diffusion-perfusion mismatch in patients with acute ischemic stroke (AIS).MethodsWe measured plasma levels of oxidative stress biomarkers such as F2-isoprostanes (F2-isoPs), to
Autor:
Gordon J. Harris, Rebecca E. Green, Loc Duyen D. Pham, Natalia S. Rost, Eng H. Lo, Allison J. Dipietro, Paul E. Milbury, Svetlana Lorenzano, Matthew B. Maas, Ken Arai, Karen L. Furie, Angel T. Som, Ona Wu, Hua Li, Fabricio O. Lima, Jeffrey B. Blumberg, Tijy Thankachan, Steven K. Feske, Muhib Khan
Background and Purpose— Oxidative stress is an early response to cerebral ischemia and is likely to play an important role in the pathogenesis of cerebral ischemic injury. We sought to evaluate whether hyperacute plasma concentrations of biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1265a973d373d988aa9b66651d210dd
https://europepmc.org/articles/PMC5828992/
https://europepmc.org/articles/PMC5828992/
Autor:
Norio Fujiwara, Emiri T. Mandeville, Brian J. Lee, Loc-Duyen D. Pham, Angel T. Som, Eng H. Lo, Ken Arai
Publikováno v:
Neuroscience letters. 633
A free radical scavenger edaravone is clinically used in Japan for acute stroke, and several basic researches have carefully examined the mechanisms of edaravone's protective effects. However, its actions on pro-inflammatory responses under stroke ar
Autor:
Takakuni Maki, John D. McNeish, Josephine Lok, Eng H. Lo, Ken Arai, Tsu Tshen Chuang, Akihiro Shindo, Kanako Itoh, Angel T. Som, Anna C. Liang, Julie C. Holder, Naohiro Egawa, Emiri T. Mandeville
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Aging and vascular comorbidities such as hypertension comprise critical cofactors that influence how the brain responds to stroke. Ischemic stress induces neurogenesis and oligodendrogenesis in younger brains. However, it remains unclear whether thes
Autor:
Loc-Duyen D. Pham, Eng H. Lo, Shuzhen Guo, Ken Arai, Nobukazu Miyamoto, Kyu-Won Kim, Kazuhide Hayakawa, Ji Hae Seo, Angel T. Som
Publikováno v:
Neuroscience Letters. 513:42-46
In gray matter, cerebral endothelium is known to provide trophic support for neighboring cells such as neurons. However, signaling from cerebral endothelium to white matter cells remains to be elucidated. Here, we show that vascular endothelial growt
Autor:
Xunming Ji, Wendy Leung, Eng H. Lo, Xiaoying Wang, Josephine Lok, Shuzhen Guo, Angel T. Som, Changhong Xing, Song Zhao, Qingzhi Wang, Yiming Zhou, Kazuhide Hayakawa
Publikováno v:
Journal of neurotrauma. 33(14)
Perturbations in blood vessels play a critical role in the pathophysiology of brain injury and neurodegeneration. Here, we use a systematic genome-wide transcriptome screening approach to investigate the vasculome after brain trauma in mice. Mice wer
Autor:
Loc-Duyen D. Pham, Kazuhide Hayakawa, Angel T. Som, Brian J. Lee, Shuzhen Guo, Eng H. Lo, Ken Arai
Publikováno v:
Journal of Neuroscience. 31:10666-10670
Originally identified as an angiogenic factor, vascular endothelial growth factor (VEGF-A) is now known to play multiple roles in the CNS, including the direct regulation of neuronal and astrocytic functions. Here, we ask whether VEGF-A can also have
Autor:
Gordon J. Harris, Natalia S. Rost, Angel T. Som, Allison J Dipietro, Svetlana Lorenzano, Jeffrey B. Blumberg, Eng H. Lo, Ken Arai, Rebecca E Green, Karen L. Furie, Loc-Duyen D. Pham, Tijy Thankachan, Steven K. Feske
Publikováno v:
Stroke. 44
Objectives: Oxidative stress occurs as part of the earliest response to ischemia and is likely to play an important role in the pathogenesis of ischemic cerebral injury. We sought to evaluate whether hyperacute plasma concentrations of F2-isoprostane