Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Angel Santos-Villarejo"'
Autor:
Eugenia Meiler, Eva Maria Lopez-Roman, Sophie Huss, Ruth Casanueva, Maciej K. Rogacki, Lluis Ballell, Laura Guijarro, Eleni Pitta, Koen Augustyns, Fraser Cunningham, Olga Balabon, David Barros Aguirre, Monica Cacho, Robert H. Bates, Angel Santos-Villarejo, Pieter Van der Veken
Publikováno v:
Journal of medicinal chemistry
In search of novel drugs against tuberculosis, we previously discovered and profiled a novel hydantoin-based family that demonstrated highly promising in vitro potency against M. tuberculosis. The compounds were found to be non-covalent inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a72f1ecaf79115a5d5f6d87dcfb66e
https://doi.org/10.1021/acs.jmedchem.0c00107
https://doi.org/10.1021/acs.jmedchem.0c00107
Autor:
Laura Guijarro, Gemma L. Nixon, Laura M. Sanz, Iñigo Angulo-Barturen, Neil G. Berry, Stephen A. Ward, Paul M. O'Neill, Jaime de Mercado, Matthew McConville, Pablo Castañeda, Maria Santos Martinez-Martinez, Noemí Bahamontes-Rosa, Jorge Fernández, Michael J. Blackman, Micol Frigerio, Lluís Ballell-Pages, Giancarlo A. Biagini, María Belén Jiménez-Díaz, Cristina de Cozar, Benigno Crespo, Gina Washbourn, Angel Santos-Villarejo, Félix Calderón
Publikováno v:
Journal of Medicinal Chemistry. 58:6448-6455
Screening of the GSK corporate collection, some 1.9 million compounds, against Plasmodium falciparum (Pf), revealed almost 14000 active hits that are now known as the Tres Cantos Antimalarial Set (TCAMS). Followup work by Calderon et al. clustered an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd14503faddd37e9215c5172bcdcb39
https://doi.org/10.1021/acs.jmedchem.5b00434
https://doi.org/10.1021/acs.jmedchem.5b00434
Autor:
Douglas J. Minick, Lourdes Rueda, Santiago Ferrer, Pablo Castañeda, Francisco J. Gamo, J. Vidal, María J. Chaparro, Raquel Gabarró, María Santos Martínez, Angel Santos-Villarejo, Jose M. Coteron, Mercedes García, María Belén Jiménez-Díaz, Michael J Witty, Félix Calderón, Sara Prats, Iñigo Angulo-Barturen, Maria Jose Lafuente, Margarita Puente, Jeremy N. Burrows, Gonzalo Colmenarejo, María Luisa León, Nicholas Cammack, Jose M. Bueno, Laura Fernández de las Heras, Esther Fernández, Elena Sandoval
Publikováno v:
ACS Medicinal Chemistry Letters. 5:657-661
Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic permeability. However, these kind of molecules are associated to numerous adverse effects, which have been extensively studied. Within the Tres Cantos Antima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea14a99c5446b043ddbd69925e99aec4
https://doi.org/10.1021/ml500015r
https://doi.org/10.1021/ml500015r
Autor:
David Barros, Ruben Gonzalez Del Rio, Santiago Ramón-García, Lluis Ballell, Charles J. Thompson, Alfonso Mendoza-Losana, Fraser Cunningham, Santiago Ferrer-Bazaga, Gaye Sweet, Angel Santos Villarejo
Publikováno v:
Scientific Reports
While modern cephalosporins developed for broad spectrum antibacterial activities have never been pursued for tuberculosis (TB) therapy, we identified first generation cephalosporins having clinically relevant inhibitory concentrations, both alone an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f660f6a9d2c0c773e1f1cefbb9614caa
http://europepmc.org/articles/PMC5039641
http://europepmc.org/articles/PMC5039641