Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Angel R Nebreda"'
Autor:
Clara Suñer, Annarita Sibilio, Judit Martín, Chiara Lara Castellazzi, Oscar Reina, Ivan Dotu, Adrià Caballé, Elisa Rivas, Vittorio Calderone, Juana Díez, Angel R Nebreda, Raúl Méndez
Publikováno v:
eLife, Vol 11 (2022)
Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin (TTP)-directed mRNA deadenyla
Externí odkaz:
https://doaj.org/article/4e3e383266cb49608da7a9a2ea87fedf
Autor:
Catrin Youssif, Monica Cubillos‐Rojas, Mònica Comalada, Elisabeth Llonch, Cristian Perna, Nabil Djouder, Angel R Nebreda
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 7, Pp n/a-n/a (2018)
Abstract The protein kinase p38α plays a key role in cell homeostasis, and p38α signaling in intestinal epithelial cells protects against colitis‐induced tumorigenesis. However, little is known on the contribution of p38α signaling in intestinal
Externí odkaz:
https://doaj.org/article/84cdac96456f47bdb679fd6db6121f23
Autor:
Nuria Matesanz, Ivana Nikolic, Magdalena Leiva, Marta Pulgarín-Alfaro, Ayelén M Santamans, Edgar Bernardo, Alfonso Mora, Leticia Herrera-Melle, Elena Rodríguez, Daniel Beiroa, Ainoa Caballero, Elena Martín-García, Rebeca Acín-Pérez, Lourdes Hernández-Cosido, Luis Leiva-Vega, Jorge L Torres, Francisco Centeno, Angel R Nebreda, José Antonio Enríquez, Rubén Nogueiras, Miguel Marcos, Guadalupe Sabio
Publikováno v:
PLoS Biology, Vol 16, Iss 7, p e2004455 (2018)
Adipose tissue has emerged as an important regulator of whole-body metabolism, and its capacity to dissipate energy in the form of heat has acquired a special relevance in recent years as potential treatment for obesity. In this context, the p38MAPK
Externí odkaz:
https://doaj.org/article/7b1012e9ad58499a8892f749da55d5de
Autor:
Antonija Kuzmanic, Ludovico Sutto, Giorgio Saladino, Angel R Nebreda, Francesco L Gervasio, Modesto Orozco
Publikováno v:
eLife, Vol 6 (2017)
p38α is a Ser/Thr protein kinase involved in a variety of cellular processes and pathological conditions, which makes it a promising pharmacological target. Although the activity of the enzyme is highly regulated, its molecular mechanism of activati
Externí odkaz:
https://doaj.org/article/c79167d437ac42e5abc1ec4d6f61c530
Autor:
Joan Pous, Blazej Baginski, Pau Martin-Malpartida, Lorena González, Margherita Scarpa, Eric Aragon, Lidia Ruiz, Rebeca A. Mees, Javier Iglesias-Fernández, Modesto Orozco, Angel R. Nebreda, Maria J. Macias
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents. These structures correspond to free forms and complexes with activators, substrate
Externí odkaz:
https://doaj.org/article/5db9dbcc41a443aea05c543a36e1e73e
Autor:
Patrick Aloy, Angel R. Nebreda, Modesto Orozco, Begoña Canovas, Victor Alcalde, Rodrigo Arroyo, Ana Igea, Samira Jaeger
Combinatorial therapeutic approaches are an imperative to improve cancer treatment, because it is critical to impede compensatory signaling mechanisms that can engender drug resistance to individual targeted drugs. Currently approved drug combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3634f37328d97ede85438321877da8be
https://doi.org/10.1158/0008-5472.c.6509207
https://doi.org/10.1158/0008-5472.c.6509207
Autor:
Patrick Aloy, Angel R. Nebreda, Modesto Orozco, Begoña Canovas, Victor Alcalde, Rodrigo Arroyo, Ana Igea, Samira Jaeger
Overview on the predicted drug combinations together with the pathways mainly involved in crosstalk inhibition (Excel table).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589a6937de4d33af5c5c464fdabb91fe
https://doi.org/10.1158/0008-5472.22415231.v1
https://doi.org/10.1158/0008-5472.22415231.v1
Autor:
Patrick Aloy, Angel R. Nebreda, Modesto Orozco, Begoña Canovas, Victor Alcalde, Rodrigo Arroyo, Ana Igea, Samira Jaeger
Sigmoid-fitted dose-response curves generated for each of the experimentally validated drug combinations in the five cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97da2e6f8427dd9df36b3d582d342bde
https://doi.org/10.1158/0008-5472.22415240
https://doi.org/10.1158/0008-5472.22415240
Autor:
Roger R. Gomis, Angel R. Nebreda, Eduard Batlle, Cristina Figueras-Puig, Mireia Cartanà, Maria Clapés, Ivan Burkov, Esther Fernandez, Adrià Cañellas, Marc Guiu, Antoni Berenguer-Llergo, Anna Bellmunt, Alicia Llorente, María Teresa Blasco, Jelena Urosevic
Carcinoma development in colorectal cancer is driven by genetic alterations in numerous signaling pathways. Alterations in the RAS-ERK1/2 pathway are associated with the shortest overall survival for patients after diagnosis of colorectal cancer meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2c2ce4811e29dc58a2d796b0829bd2b
https://doi.org/10.1158/0008-5472.c.6512596.v1
https://doi.org/10.1158/0008-5472.c.6512596.v1
Autor:
Roger R. Gomis, Angel R. Nebreda, Eduard Batlle, Cristina Figueras-Puig, Mireia Cartanà, Maria Clapés, Ivan Burkov, Esther Fernandez, Adrià Cañellas, Marc Guiu, Antoni Berenguer-Llergo, Anna Bellmunt, Alicia Llorente, María Teresa Blasco, Jelena Urosevic
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21db5e948ca710c92a496db9d1fb538b
https://doi.org/10.1158/0008-5472.22427221
https://doi.org/10.1158/0008-5472.22427221