Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Angel M. Padilla"'
Autor:
Angel M. Padilla, Charles Rosenberg, Peter Cook, Fernando Sanchez-Valdez, Caroline McElhannon, Rick L. Tarleton
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Although parasite entry through breaks in the skin or mucosa is one of the main routes of natural transmission of Trypanosoma cruzi, little is known about the host cell types initially invaded nor the ability of those host cells to initiate
Externí odkaz:
https://doaj.org/article/e65f0a12855e4550a7b3842d2c301f38
Autor:
Andrés Sanchez Alberti, Augusto E. Bivona, Natacha Cerny, Kai Schulze, Sebastian Weißmann, Thomas Ebensen, Celina Morales, Angel M. Padilla, Silvia I. Cazorla, Rick L. Tarleton, Carlos A. Guzmán, Emilio L. Malchiodi
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-12 (2017)
Chagas disease: protecting from chronic parasitic disease An amalgamation of parasitic proteins may be the first effective vaccine against the as yet untreatable chronic phase of Chagas disease. The infliction, caused by the parasite Trypanosoma cruz
Externí odkaz:
https://doaj.org/article/ae1f0273188b48babe69f8e20ee1e766
Autor:
Juan M. Bustamante, Angel M. Padilla, Brooke White, Lisa D. Auckland, Rachel E. Busselman, Stephanie Collins, Elizabeth L. Malcolm, Briana F. Wilson, Ashley B. Saunders, Sarah A. Hamer, Rick L. Tarleton
Trypanosoma cruzi naturally infects a wide variety of wild and domesticated mammals, in addition to humans. Depending on the infection dose and other factors, the acute infection can be life-threatening, and in all cases, the risk of chagasic heart d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f880366077afcb62e8bfbefddfcc06
https://doi.org/10.1101/2022.07.25.501361
https://doi.org/10.1101/2022.07.25.501361
Autor:
Angel M. Padilla, Wei Wang, Tsutomu Akama, David S. Carter, Eric Easom, Yvonne Freund, Jason S. Halladay, Yang Liu, Sarah A. Hamer, Carolyn L. Hodo, Gregory K. Wilkerson, Dylan Orr, Brooke White, Arlene George, Huifeng Shen, Yiru Jin, Michael Zhuo Wang, Susanna Tse, Robert T. Jacobs, Rick L. Tarleton
Publikováno v:
Nature microbiology. 7(10)
Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a107b3816471fc4544d97ceaccbbe5e
https://pubmed.ncbi.nlm.nih.gov/36195774
https://pubmed.ncbi.nlm.nih.gov/36195774
Autor:
Maria Teresa Quesada-Campos, Juan Cantizani Perez, Angel M. Padilla, Rick L. Tarleton, Ignacio Cotillo, Maria L. Marco, Isabel Saiz-Nicolas, Charlotte Fleau, Juan Miguel-Siles, Gilles Courtemanche
Publikováno v:
Journal of Medicinal Chemistry. 62:10362-10375
Acylaminobenzothiazole hits were identified as potential inhibitors of Trypanosoma cruzi replication, a parasite responsible for Chagas disease. We selected compound 1 for lead optimization, aiming to improve in parallel its anti-T. cruzi activity (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5946961f94bb8608d41ed4f359e0228f
https://doi.org/10.1021/acs.jmedchem.9b01429
https://doi.org/10.1021/acs.jmedchem.9b01429
Autor:
John L. VandeBerg, Tre J. Landry, Angel M. Padilla, Gretchen Cooley, Phil Y. Yao, Rick L. Tarleton, Susan M. Mahaney, Isabela Ribeiro
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009141 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009141 (2021)
Trypanosoma cruzi, the causative agent of human Chagas disease, is endemic to the southern region of the United States where it routinely infects many host species. The indoor/outdoor housing configuration used in many non-human primate research and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5868355d3a738c0fd10a8306bc9efa9
https://doi.org/10.1101/2021.01.22.427760
https://doi.org/10.1101/2021.01.22.427760
Autor:
Wei Wang, Brooke E. White, Rick L. Tarleton, Juan M. Bustamante, Fernando J Sánchez-Valdéz, Angel M. Padilla
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Sci Transl Med
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Sci Transl Med
A major contributor to treatment failure in Chagas disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is that current treatment regimens do not address the drug insensitivity of transiently dormant T. cruzi amastigotes. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016aca297a5051ee0394639296c61bb9
https://doi.org/10.1126/scitranslmed.abb7656
https://doi.org/10.1126/scitranslmed.abb7656
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1418 (2011)
Trypanosoma cruzi is a protozoan parasite that causes severe disease in millions of habitants of developing countries. Currently there is no vaccine to prevent this disease and the available drugs have the consequences of side effects. Live vaccines
Externí odkaz:
https://doaj.org/article/d56fa15e7db04fdab1b7aacb4aa9d5df
Autor:
Adriana M C Canavaci, Juan M Bustamante, Angel M Padilla, Cecilia M Perez Brandan, Laura J Simpson, Dan Xu, Courtney L Boehlke, Rick L Tarleton
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 7, p e740 (2010)
The two available drugs for treatment of T. cruzi infection, nifurtimox and benznidazole (BZ), have potential toxic side effects and variable efficacy, contributing to their low rate of use. With scant economic resources available for antiparasitic d
Externí odkaz:
https://doaj.org/article/d0e1712d270f45dfab80019a6ae59c32
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991471
Chagas disease agent, Trypanosoma cruzi, is capable to persist after prolonged drug treatment using effective drugs. The reason of treatment failure is not known, but recent development of highly sensible bioluminescence imaging coupled to tissue cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460af9205b6219f7a4604b69bb53ce54
https://doi.org/10.1007/978-1-4939-9148-8_13
https://doi.org/10.1007/978-1-4939-9148-8_13