MHC Intratumoral Heterogeneity May Predict Cancer Progression and Response to Immunotherapy

Autor: Irene Romero, Cristina Garrido, Ignacio Algarra, Virginia Chamorro, Antonia Collado, Federico Garrido, Angel M. Garcia-Lora

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

An individual tumor can present intratumoral phenotypic heterogeneity, containing tumor cells with different phenotypes that do not present irreversible genetic alterations. We have developed a mouse cancer model, named GR9, derived from a methylchol

Externí odkaz: https://doaj.org/article/9cb9712f08234088af188dfe0edc7c6c

Restoration of MHC-I on Tumor Cells by Fhit Transfection Promotes Immune Rejection and Acts as an Individualized Immunotherapeutic Vaccine

Autor: Alba S-Montalvo, Federico Garrido, Antonia Collado, Angel M. Garcia-Lora, María Pulido, Irene Romero, Virginia Chamorro, Ignacio Algarra

Publikováno v: Cancers
Cancers, Vol. 12, no. 6, p. 1563 [1-23] (2020)
Cancers, Vol 12, Iss 1563, p 1563 (2020)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Volume 12
Issue 6

The authors thank I. Linares, V. Sanz, A.B. Rodriguez, A.I. Rodriguez and E. Arias for technical advice and R. Davies for editorial assistance.
The capacity of cytotoxic-T lymphocytes to recognize and destroy tumor cells depends on the surface e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d5262197b36ecd4de9c3ffed856d7f
https://doi.org/10.3390/cancers12061563

Metastases in Immune-Mediated Dormancy: A New Opportunity for Targeting Cancer

Autor: Angel M. Garcia-Lora, Irene Romero, Federico Garrido

Publikováno v: Cancer Research. 74:6750-6757

The aim of any anticancer treatment is to avoid, control, or eliminate disseminated tumor cells. Clinical and experimental evidence has revealed that metastases can remain in a latency state, that is, metastasis dormancy. Three mechanisms are thought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39994734142399d18e62a698462e025
https://doi.org/10.1158/0008-5472.can-14-2406

Cancer immune escape: implications for immunotherapy, Granada, Spain, October 3–5, 2011

Autor: Federico Garrido, Natalia Aptsiauri, Teresa Cabrera, Angel M. Garcia-Lora

Publikováno v: Cancer Immunology, Immunotherapy. 61:739-745

Since 1985, a series of international conferences have taken place in Granada on the role of MHC class I antigens in cancer immune escape. This latest meetings, sponsored by the Ramon Areces Foundation, University of Granada, and University Hospital

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61566108703ce788ce2af2d430b83f14
https://doi.org/10.1007/s00262-012-1213-9

Immunotherapy eradicates metastases with reversible defects in MHC class I expression

Autor: Federico Garrido, Angel M. Garcia-Lora, Antonia Collado, Bárbara Cancela, Irene Romero, Enrique Berruguilla, Ignacio Algarra, Cristina Garrido

Publikováno v: Cancer Immunology, Immunotherapy. 60:1257-1268

Tumor or metastatic cells lose MHC class I (MHC-I) expression during cancer progression as an escape mechanism from immune surveillance. These defects in MHC-I may be reversible by cytokines or different agents (soft lesions) or irreversible due to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8d71e793bbe9789f4f3416d82751a2
https://doi.org/10.1007/s00262-011-1027-1