Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases.

Autor: Tomas Majtan, Angel L Pey, Roberto Fernández, José A Fernández, Luis A Martínez-Cruz, Jan P Kraus

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105290 (2014)

Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine. Although the pathway itself i

Externí odkaz: https://doaj.org/article/beefd4db48e5421f9ab4d2d652de855e

The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation.

Autor: Khanh K Dao, Angel L Pey, Anja Underhaug Gjerde, Knut Teigen, In-Ja L Byeon, Stein O Døskeland, Angela M Gronenborn, Aurora Martinez

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17602 (2011)

BackgroundThe regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rathe

Externí odkaz: https://doaj.org/article/31c7d72bd67e4781abe6317a5e2de01e

Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants

Autor: Jose L. Neira, Athi N. Naganathan, Noel Mesa-Torres, Eduardo Salido, Angel L. Pey

Publikováno v: Molecules, Vol 27, Iss 24, p 8762 (2022)

The mutations G170R and I244T are the most common disease cause in primary hyperoxaluria type I (PH1). These mutations cause the misfolding of the AGT protein in the minor allele AGT-LM that contains the P11L polymorphism, which may affect the foldin

Externí odkaz: https://doaj.org/article/70acc055b13a40a58a70307115ca250f

Perturbation analysis in the N-terminal domain of hPGK1: a biophysical, structural and statistical mechanical study

Autor: Juan Luis Pacheco-García, Dmitry S. Loginov, Athi N. Naganathan, Pavla Vankova, Mario Cano-Muñoz, Petr Man, Angel L. Pey

Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer development and rare genetic diseases that affect several of its features.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::885223ee7bd98a2a21a5e22646fb39b6
https://doi.org/10.21203/rs.3.rs-1945879/v1

Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

Autor: Juan Luis Pacheco-Garcia, Dmitry S. Loginov, Ernesto Anoz-Carbonell, Pavla Vankova, Rogelio Palomino-Morales, Eduardo Salido, Petr Man, Milagros Medina, Athi N. Naganathan, Angel L. Pey

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Antioxidants; Volume 11; Issue 6; Pages: 1110

Allosterism is a common phenomenon in protein biochemistry that allows rapid regulation of protein stability; dynamics and function. However, the mechanisms by which allosterism occurs (by mutations or post-translational modifications (PTMs)) may be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633b41dc901b7e71eff751e94b9e07ac
http://hdl.handle.net/10481/75923