Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Angel Goñi-Moreno"'
Autor:
Lewis Grozinger, Martyn Amos, Thomas E. Gorochowski, Pablo Carbonell, Diego A. Oyarzún, Ruud Stoof, Harold Fellermann, Paolo Zuliani, Huseyin Tas, Angel Goñi-Moreno
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Synthetic biology uses cells as its computing substrate, often based on the genetic circuit concept. In this Perspective, the authors argue that existing synthetic biology approaches based on classical models of computation limit the potential of bio
Externí odkaz:
https://doaj.org/article/299394da6ed34fa1a1a67b8fdcfad878
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
The transfer of information between DNA, RNA, and proteins in a bacterium is often compared to the decoding of a piece of software in a computer. However, the tridimensional layout and the relational logic of the cognate biological hardware, i.e., th
Externí odkaz:
https://doaj.org/article/79dc295731614c288c0dce071eba61f7
Publikováno v:
Engineering Biology (2019)
Synthetic biology is a relatively young field, although it builds upon disciplines whose roots go back centuries. Recently, its practitioners have tended to move into the field out of interest or by chance, and come from a wide variety of backgrounds
Externí odkaz:
https://doaj.org/article/d31b457d406e432cb9455e734cafe8a4
High-Performance Biocomputing in Synthetic Biology–Integrated Transcriptional and Metabolic Circuits
Autor:
Angel Goñi-Moreno, Pablo I. Nikel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Biocomputing uses molecular biology parts as the hardware to implement computational devices. By following pre-defined rules, often hard-coded into biological systems, these devices are able to process inputs and return outputs—thus computing infor
Externí odkaz:
https://doaj.org/article/e991e8a5e40a486bbbb77e41a372f44f
Autor:
Juan-Carlos García-Betancur, Angel Goñi-Moreno, Thomas Horger, Melanie Schott, Malvika Sharan, Julian Eikmeier, Barbara Wohlmuth, Alma Zernecke, Knut Ohlsen, Christina Kuttler, Daniel Lopez
Publikováno v:
eLife, Vol 6 (2017)
A central question to biology is how pathogenic bacteria initiate acute or chronic infections. Here we describe a genetic program for cell-fate decision in the opportunistic human pathogen Staphylococcus aureus, which generates the phenotypic bifurca
Externí odkaz:
https://doaj.org/article/da421871f1184b77b1f8be354aa35666
Publikováno v:
Life, Vol 9, Iss 1, p 14 (2019)
We present a scheme for implementing a version of task switching in engineered bacteria, based on the manipulation of plasmid copy numbers. Our method allows for the embedding of multiple computations in a cellular population, whilst minimising resou
Externí odkaz:
https://doaj.org/article/cea44e24acc54287aa544ca3317b7da6
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65986 (2013)
Recent efforts in synthetic biology have focussed on the implementation of logical functions within living cells. One aim is to facilitate both internal "re-programming" and external control of cells, with potential applications in a wide range of do
Externí odkaz:
https://doaj.org/article/d451e9e399fb4773950bd95bc1c4fffd
Autor:
Esteban Martínez-García, Sofía Fraile, Elena Algar, Tomás Aparicio, Elena Velázquez, Belén Calles, Huseyin Tas, Blas Blázquez, Bruno Martín, Clara Prieto, Lucas Sánchez-Sampedro, Morten H H Nørholm, Daniel C Volke, Nicolas T Wirth, Pavel Dvořák, Lorea Alejaldre, Lewis Grozinger, Matthew Crowther, Angel Goñi-Moreno, Pablo I Nikel, Juan Nogales, Víctor de Lorenzo
Publikováno v:
Martínez-García, E, Fraile, S, Algar, E, Aparicio, T, Velázquez, E, Calles, B, Tas, H, Blázquez, B, Martín, B, Prieto, C, Sánchez-Sampedro, L, Nørholm, M H H, Volke, D C, Wirth, N T, Dvořák, P, Alejaldre, L, Grozinger, L, Crowther, M, Goñi-Moreno, A, Nikel, P I, Nogales, J & de Lorenzo, V 2023, ' SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes ', Nucleic Acids Research, vol. 51, no. D1, pp. D1558–D1567 . https://doi.org/10.1093/nar/gkac1059
The SEVA platform (https://seva-plasmids.com) was launched one decade ago, both as a database (DB) and as a physical repository of plasmid vectors for genetic analysis and engineering of Gram-negative bacteria with a structure and nomenclature that f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f1b039e447131b2ad3fae697ca1df4
https://orbit.dtu.dk/en/publications/4e321df4-ea29-4104-8b3f-a08b9154a3a8
https://orbit.dtu.dk/en/publications/4e321df4-ea29-4104-8b3f-a08b9154a3a8
Publikováno v:
ACS synthetic biology. 11(9)
9 Pág. Centro de Biotecnología y Genómica de Plantas
As genetic circuits become more sophisticated, the size and complexity of data about their designs increase. The data captured goes beyond genetic sequences alone; information about circuit
As genetic circuits become more sophisticated, the size and complexity of data about their designs increase. The data captured goes beyond genetic sequences alone; information about circuit
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Biofoundries are highly automated facilities that enable the rapid and efficient design, build, test, and learn cycle of biomanufacturing and engineering biology, which is applicable to both research and industrial production. However, developing a b