Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Angel Garcia‐Diaz"'
Autor:
Juan Manuel Martí, Angel Garcia-Diaz, Daniel Delgado-Bellido, Francisco O'Valle, Ariannys González-Flores, Onintza Carlevaris, José Manuel Rodríguez-Vargas, Jean Christophe Amé, Françoise Dantzer, George L. King, Klaudia Dziedzic, Edurne Berra, E. de Álava, A.T. Amaral, Ester M. Hammond, F. Javier Oliver
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101885- (2021)
Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients. PARP-1 inhibitors are used in the clinic to treat BRCAness breast
Externí odkaz:
https://doaj.org/article/0f826f2e9407497a88ab90c6673c93fa
Autor:
Daniel Delgado-Bellido, Concepción Bueno-Galera, Laura López-Jiménez, Angel Garcia-Diaz, F. Javier Oliver
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Aberrant extra-vascular expression of VE-cadherin has been observed in metastasis associated with Vasculogenic Mimicry (VM); we have recently shown that in VM prone cells VE-cadherin is mainly in the form of phospho-VE-cadherin in Y658 allowing incre
Externí odkaz:
https://doaj.org/article/f63900db6b214624a8aa57fce2f0ed7b
Autor:
Angel Garcia-Diaz, Daniel Sanghoon Shin, Blanca Homet Moreno, Justin Saco, Helena Escuin-Ordinas, Gabriel Abril Rodriguez, Jesse M. Zaretsky, Lu Sun, Willy Hugo, Xiaoyan Wang, Giulia Parisi, Cristina Puig Saus, Davis Y. Torrejon, Thomas G. Graeber, Begonya Comin-Anduix, Siwen Hu-Lieskovan, Robert Damoiseaux, Roger S. Lo, Antoni Ribas
Publikováno v:
Cell Reports, Vol 19, Iss 6, Pp 1189-1201 (2017)
PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecu
Externí odkaz:
https://doaj.org/article/e5b58d91cebc41a38766402ee83a9fa5
Autor:
Mónica Fernández‐Cortés, Daniel Delgado‐Bellido, Eloísa Bermúdez‐Jiménez, Jesús M Paramio, Francisco O'Valle, Stefan Vinckier, Peter Carmeliet, Angel Garcia‐Diaz, F Javier Oliver
Publikováno v:
Fernández-Cortés, M, Delgado-Bellido, D, Bermúdez-Jiménez, E, Paramio, J M, O'Valle, F, Vinckier, S, Carmeliet, P, Garcia-Diaz, A & Oliver, F J 2023, ' PARP inhibition promotes endothelial-like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry ', Journal of Pathology, vol. 259, no. 3, pp. 318-330 . https://doi.org/10.1002/path.6043
Vasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop pseudovascular structures without the participation of endothelial cells. PARP1 is implicated in the activation of hypoxia-inducible factors, which are crucia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044de670cce5af61d066b4dbb34cd688
https://doi.org/10.1002/path.6043
https://doi.org/10.1002/path.6043
Autor:
Antoni Ribas, Siwen Hu-Lieskovan, Begoña Comin-Anduix, Beata Berent-Maoz, Catherine S. Grasso, Pau Mascaro, Christopher M. Lee, Agustin Vega-Crespo, Paige Krystofinski, Thomas Wohlwender, Gardenia Cheung-Lau, Cristina Puig-Saus, Angel Garcia-Diaz, Jesse M. Zaretsky, Giulia Parisi, Anusha Kalbasi, Katie M. Campbell, Jennifer Tsoi, Ameya S. Champhekar, Gabriel Abril-Rodriguez, Davis Y. Torrejon
Mechanism-based strategies to overcome resistance to PD-1 blockade therapy are urgently needed. We developed genetic acquired resistant models of JAK1, JAK2, and B2M loss-of-function mutations by gene knockout in human and murine cell lines. Human me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdae21e426b8a218be5691b762b2da24
https://doi.org/10.1158/2159-8290.c.6547868.v1
https://doi.org/10.1158/2159-8290.c.6547868.v1
Autor:
Antoni Ribas, Siwen Hu-Lieskovan, Begoña Comin-Anduix, Thomas G. Graeber, Ashani T. Weeraratna, Marcus Bosenberg, Abibatou Ndoye, Katrina Meeth, Lidia Robert, Giulia Parisi, Jennifer Tsoi, Angel Garcia-Diaz, Jesse M. Zaretsky, Blanca Homet Moreno
IGV plot of RNA-Seq from YUMM1.1, YUMM1.7 and YUMM2.1; western blot analysis of cytoplasmic and nuclear beta-catenin in YUMM1.7 and YUMM2.1 cell lines with or without exposure to 10 uM 4HT for 48 hours; top-flash activity of total beta-catenin in YUM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29853d7663ca1ed904f998f1312b5151
https://doi.org/10.1158/2326-6066.22538134.v1
https://doi.org/10.1158/2326-6066.22538134.v1
Autor:
Antoni Ribas, Begoña Comin-Anduix, Roger S. Lo, Thomas G. Graeber, Paul C. Tumeh, Luis A. Diaz, Drew M. Pardoll, Dung T. Le, I. Peter Shintaku, Beata Berent-Maoz, Elizabeth Seja, Grace Cherry, Bartosz Chmielowski, Ariel Azhdam, Giulia Parisi, Gabriel Abril Rodriguez, Nicolaos Palaskas, Davis Y. Torrejon, Salemiz Sandoval, Willy Hugo, Catherine S. Grasso, Anusha Kalbasi, Siwen Hu-Lieskovan, Angel Garcia-Diaz, Helena Escuin-Ordinas, Jesse M. Zaretsky, Daniel Sanghoon Shin
Supplementary Figure 1. Exome sequencing and copy number changes in M431 and corresponding whole-tumor biopsy. Supplementary Figure 2. Mutations in antigen presentation machinery from anti-PD1 treated melanoma cohort. Supplementary Figure 3. Immunohi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5100eca3a078e24a69cfec2868922778
https://doi.org/10.1158/2159-8290.22532264.v1
https://doi.org/10.1158/2159-8290.22532264.v1
Autor:
Antoni Ribas, Siwen Hu-Lieskovan, Begoña Comin-Anduix, Thomas G. Graeber, Ashani T. Weeraratna, Marcus Bosenberg, Abibatou Ndoye, Katrina Meeth, Lidia Robert, Giulia Parisi, Jennifer Tsoi, Angel Garcia-Diaz, Jesse M. Zaretsky, Blanca Homet Moreno
IGV plot exome sequencing from YUMM1.1, YUMM1.7 and YUMM2.1, tumor growth curve of YUMM1.7 and B16 with 4 mice in each group, analysis of the non-synonymous mutational load compared to a strain-matched normal with known dbSNP variants excluded.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8126b2951a08508e83db307cd2241328
https://doi.org/10.1158/2326-6066.22538140
https://doi.org/10.1158/2326-6066.22538140
Autor:
Antoni Ribas, Siwen Hu-Lieskovan, Begoña Comin-Anduix, Thomas G. Graeber, Ashani T. Weeraratna, Marcus Bosenberg, Abibatou Ndoye, Katrina Meeth, Lidia Robert, Giulia Parisi, Jennifer Tsoi, Angel Garcia-Diaz, Jesse M. Zaretsky, Blanca Homet Moreno
Gating strategy of CD11c+B220-, CD11c+B220+, CD11c+B220-CD8+ and CD11c+B220-CD103+ cells; gating strategy of CD11b+MHC-IIhigh DCs in CD11c+ cells; gating strategy of CD11b+F4/80+TAMs, CD11b+F4/80+MHC-IIlow TAMs and CD11b+F4/80+MHC-IIhigh TAMs; gating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b5fea2895daba997b36b7f5c30862e
https://doi.org/10.1158/2326-6066.22538131.v1
https://doi.org/10.1158/2326-6066.22538131.v1
Autor:
Antoni Ribas, Siwen Hu-Lieskovan, Begoña Comin-Anduix, Thomas G. Graeber, Ashani T. Weeraratna, Marcus Bosenberg, Abibatou Ndoye, Katrina Meeth, Lidia Robert, Giulia Parisi, Jennifer Tsoi, Angel Garcia-Diaz, Jesse M. Zaretsky, Blanca Homet Moreno
Quantification of CD3+CD8+ (CD8 T-cells) and (B) CD3+CD4+ (CD4 T-cells) in both tumors and spleens in YUMM2.1; gating strategy after exclusion of dead cells of CD3+CD8+ and CD3+CD4+ cells after gating for CD3+ cells; quantification of CD3+CD8+ (CD8 T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8636bdc6d34378403ad6d43eeea426
https://doi.org/10.1158/2326-6066.22538137.v1
https://doi.org/10.1158/2326-6066.22538137.v1