Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Angel Cedazo‐Minguez"'
Autor:
Fokion Spanos, Gorka Gerenu, Julen Goikolea, María Latorre-Leal, Hugo Balleza-Tapia, Karen Gomez, Laura Álvarez-Jiménez, Antonio Piras, Marta Gómez-Galán, André Fisahn, Angel Cedazo-Minguez, Silvia Maioli, Raúl Loera-Valencia
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Astrocytes represent the most abundant cell type in the brain, where they play critical roles in synaptic transmission, cognition, and behavior. Recent discoveries show astrocytes are involved in synaptic dysfunction during Alzheimer’s disease (AD)
Externí odkaz:
https://doaj.org/article/aba4a55ab1874e88a6b617324d3db88b
Autor:
Francesca Eroli, Christina Tsagkogianni, Stefania Zerial, Felix Andersson, Zeynep Acararicin, Maria Latorre-Leal, Jonas Wastesson, Angel Cedazo-Minguez, Kristina Johnell, Silvia Maioli
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100309- (2024)
Objectives: Cardiovascular conditions like hypercholesterolemia and hypertension increase the risk for Alzheimer's Disease (AD). Thus, certain AD risk profiles may benefit from optimized multi- medication therapies including for example cholesterol-l
Externí odkaz:
https://doaj.org/article/3a924c5836b3426ea6ee9dea1e64fe98
Autor:
Julen Goikolea, Gorka Gerenu, Makrina Daniilidou, Francesca Mangialasche, Patrizia Mecocci, Tiia Ngandu, Juha Rinne, Alina Solomon, Miia Kivipelto, Angel Cedazo-Minguez, Anna Sandebring-Matton, Silvia Maioli
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background Thioredoxin-80 (Trx80) is a cleavage product from the redox-active protein Thioredoxin-1 and has been previously described as a pro-inflammatory cytokine secreted by immune cells. Previous studies in our group reported that Trx80
Externí odkaz:
https://doaj.org/article/79f285263a064cd2a9cf39e3ec800881
Autor:
Anna Sandebring-Matton, Julen Goikolea, Ingemar Björkhem, Laura Paternain, Nina Kemppainen, Tiina Laatikainen, Tiia Ngandu, Juha Rinne, Hilkka Soininen, Angel Cedazo-Minguez, Alina Solomon, Miia Kivipelto
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Background 27-Hydroxycholesterol (27-OH), the main circulating oxysterol in humans and the potential missing link between peripheral hypercholesterolemia and Alzheimer’s disease (AD), has not been investigated previously in relation to cog
Externí odkaz:
https://doaj.org/article/331e6ffc2e9744dcabc5a657dfe423ad
Autor:
Raul Loera-Valencia, Erika Vazquez-Juarez, Alberto Muñoz, Gorka Gerenu, Marta Gómez-Galán, Maria Lindskog, Javier DeFelipe, Angel Cedazo-Minguez, Paula Merino-Serrais
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Alterations in brain cholesterol homeostasis in midlife are correlated with a higher risk of developing Alzheimer’s disease (AD). However, global cholesterol-lowering therapies have yielded mixed results when it comes to slowing down or pr
Externí odkaz:
https://doaj.org/article/0b049b45ec844c18afc7850c0fa00835
Autor:
Mahmod Panahi, Patricia Rodriguez Rodriguez, Seyed-Mohammad Fereshtehnejad, Donia Arafa, Nenad Bogdanovic, Bengt Winblad, Angel Cedazo-Minguez, Juha Rinne, Taher Darreh-Shori, Yoshiki Hase, Raj N. Kalaria, Matti Viitanen, Homira Behbahani
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Typical cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the human NOTCH3 gene. Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy i
Externí odkaz:
https://doaj.org/article/f0ffe195729647bdadfe04bd8db3b90f
Autor:
Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Synapse impairment is thought to be an early event in Alzheimer's disease (AD); dysfunction and loss of synapses are linked to cognitive symptoms that precede neuronal loss and neurodegeneration. Neurogranin (Ng) is a somatodendritic protein that has
Externí odkaz:
https://doaj.org/article/2a2166a0818947feb47ea5f79bda33ee
Autor:
Francisco Gil‐Bea, Susanne Akterin, Torbjörn Persson, Laura Mateos, Anna Sandebring, Javier Avila‐Cariño, Angel Gutierrez‐Rodriguez, Erik Sundström, Arne Holmgren, Bengt Winblad, Angel Cedazo‐Minguez
Publikováno v:
EMBO Molecular Medicine, Vol 4, Iss 10, Pp 1097-1111 (2012)
Abstract Thioredoxin‐1 (Trx1) is an endogenous dithiol reductant and antioxidant that was shown to be decreased in Alzheimer's disease (AD) neurons. A truncated form of Trx1, thioredoxin 80 (Trx80), was reported to be secreted from monocytes having
Externí odkaz:
https://doaj.org/article/0d6de4d97b3243b09004e73b1e61b89e
Autor:
Silvia Maioli, Ann Båvner, Zeina Ali, Maura Heverin, Muhammad-Al-Mustafa Ismail, Elena Puerta, Maria Olin, Ahmed Saeed, Marjan Shafaati, Paolo Parini, Angel Cedazo-Minguez, Ingemar Björkhem
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68534 (2013)
We previously described a heterozygous mouse model overexpressing human HA-tagged 24S-hydroxylase (CYP46A1) utilizing a ubiquitous expression vector. In this study, we generated homozygotes of these mice with circulating levels of 24OH 30-60% higher
Externí odkaz:
https://doaj.org/article/2ff61c800796445390811baa10e7bf25
Autor:
Vilma Alanko, Adhara Gaminde‐Blasco, Tania Quintela‐López, Raúl Loera‐Valencia, Alina Solomon, Ingemar Björkhem, Angel Cedazo‐Minguez, Silvia Maioli, Graziella Tabacaru, María Latorre‐Leal, Carlos Matute, Miia Kivipelto, Elena Alberdi, Anna Sandebring‐Matton
Publikováno v:
Glia. 71:1414-1428
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf749767c89e96ac7d960d2955368c73
https://doi.org/10.1002/glia.24348
https://doi.org/10.1002/glia.24348