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Idiopathic neutropenia (IN) in children is characterized by decreased neutrophil counts (1500/microl), can be acute or chronic (greater than 6 months duration). The pathophysiology is not well understood; therefore, potential mechanisms of pediatric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c19e773de64cb750a0975774e142614
https://europepmc.org/articles/PMC4161459/
https://europepmc.org/articles/PMC4161459/
Publikováno v:
Blood. 110:3291-3291
Idiopathic neutropenia in children is marked by low neutrophil counts ( Patient number Chronicity Age FasL (pg/ml) Anti-neutrophil Ab Fold increase in neutrophil death over control plasma Fold increase in apoptosis over control plasma 1 chronic 2 yrs
Autor:
Kari C. Nadeau, Kokil Bakshi, Tanya Carroll, Angel Callejas, Jim Schilling, Michael Jeng, Alan M. Krensky, Ya-Wun Yang, Ken Lau, Wendy Wong, Carol Clayberger
Publikováno v:
Blood. 108:3851-3851
In order to explore possible mechanisms for idiopathic neutropenia, molecular and functional analyses on neutrophils and plasma of pediatric neutropenic patients were performed. 22 subjects, 8 acute and 14 chronic neutropenia, aged 5 months to 12 yea