Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Angel Baldan"'
Autor:
Bethan L. Clifford, Kelsey E. Jarrett, Joan Cheng, Angela Cheng, Marcus Seldin, Pauline Morand, Richard Lee, Mary Chen, Angel Baldan, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling
Publikováno v:
Circulation Research. 132:849-863
Background: Removal of circulating plasma low-density lipoprotein cholesterol (LDL-C) by the liver relies on efficient endocytosis and intracellular vesicle trafficking. Increasing the availability of hepatic LDL receptors (LDLRs) remains a major cli
Autor:
Jordan Cheng, Elizabeth J. Tarling, Jarrett Ke, Angel Baldan, de Aguiar Vallim Tq, Bethan L. Clifford, Richard T. Lee, Angela Cheng, Marcus M. Seldin, Pauline Morand
Increasing the availability of hepatic low-density lipoprotein receptors (LDLR) remains a major clinical target for reducing circulating plasma LDL cholesterol (LDL-C) levels. Here, we identify the molecular mechanism underlying genome-wide significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21968ab5ee672b854787569447c33675
https://doi.org/10.1101/2020.12.09.415323
https://doi.org/10.1101/2020.12.09.415323
Autor:
Elizabeth J Tarling, Joan Cheng, Angela Cheng, Judy Wu, Tamer Sallam, Angel Baldan, Thomas Q de Aguiar Vallim
Publikováno v:
Circulation. 136
Introduction: Removal of cholesterol from atherosclerotic lesions remains an unmet therapeutic need. The ATP Binding Cassette Transporter A1 (ABCA1) plays a key role in the efflux of cholesterol from macrophages, therefore strategies that increase ma
Autor:
Thomas Q de Aguiar Vallim, Elinor Lee, David J Merriott, Christopher N Goulbourne, Joan Cheng, Angela Cheng, Ayelet Gonen, Elisa N Palldino, Katayun Barmak, David A Ford, Tisha Wang, Angel Baldan, Elizabeth J Tarling
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Inflammation is a hallmark characteristic of many diseases, including atherosclerosis and respiratory distress, and it is also a stereotypical response of the innate immune system to pathogens. Given the central role both inflammation and lipid homeo
Autor:
Thomas Q de Aguiar Vallim, Angel Baldan, Joan Cheng, Christopher Goulbourne, Elin Org, Aldons J Lusis, Elizabeth J Tarling
Publikováno v:
Circulation. 132
Chronic respiratory diseases are the 3rd leading cause of death, and individuals suffering from respiratory distress are at risk for cardiovascular complications. Changes in the commensal bacteria in the lung have been associated with the development
Autor:
Thomas Q de Aguiar Vallim, Christopher N Goulbourne, Joan Cheng, Tieyan Han, Joy Frank, David A Ford, Angel Baldan, Elizabeth Tarling
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Pulmonary alveolar proteinosis (PAP) is a rare disease caused by the accumulation of surfactant proteins and lipids in the pulmonary alveoli resulting in respiratory distress. For almost all reported cases the underlying cause is unknown. Synthesis a
Autor:
Angel Baldan, Ayelet Gonen, Christina Choung, Tyler Marquart, Xuchu Que, Cody Diehl, Joseph L Witztum, Elizabeth J Tarling
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Many metabolic diseases, including atherosclerosis, type 2 diabetes, pulmonary alveolar proteinosis (PAP), and obesity, have a chronic inflammatory component involving both innate and adaptive immunity. Mice lacking the ATP binding cassette (ABC) tra
Autor:
Cedric Langhi, Angel Baldan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
The cell death-inducing DFFA-like effector c (CIDEC; known as FSP27 or fat-specific protein 27 in rodents) is a lipid droplet (LD)-associated protein that is mainly expressed in white adipose tissue, where it promotes triglyceride storage. Fsp27 leve
Autor:
Elizabeth J Tarling, Ayelet Gonen, Xuchu Que, Cody Diehl, Joseph L Witztum, Angel Baldan, Peter A Edwards
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33
The oxidation of LDL, a key event in the pathogenesis of atherosclerosis, generates multiple oxidation-specific neo-epitopes (OSE). These epitopes are recognized by natural germ line IgM antibodies that are secreted by B-1 B cells. Mice lacking the A
Autor:
Nathan L. Price, Abhishek K. Singh, Noemi Rotllan, Leigh Goedeke, Allison Wing, Alberto Canfrán-Duque, Alberto Diaz-Ruiz, Elisa Araldi, Ángel Baldán, Joao-Paulo Camporez, Yajaira Suárez, Matthew S. Rodeheffer, Gerald I. Shulman, Rafael de Cabo, Carlos Fernández-Hernando
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 2133-2145 (2018)
Summary: While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovas
Externí odkaz:
https://doaj.org/article/e344e7cdc5634e7db68d175d5c1581a0