Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma

Autor: Piyapan Suwattananuruk, Sukanya Yaset, Chanisa Chotipanich, Angel Moldes-Anaya, Rune Sundset, Rodrigo Berzaghi, Stine Figenschau, Sandra Claes, Dominique Schols, Pornchai Rojsitthisak, Mathias Kranz, Opa Vajragupta

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-19 (2024)

Abstract Background This study aimed to develop a novel positron emission tomography (PET) tracer, [68Ga]Ga-TD-01, for CXCR4 imaging. To achieve this goal, the molecular scaffold of TIQ15 was tuned by conjugation with the DOTA chelator to make it sui

Externí odkaz: https://doaj.org/article/c3db7fc51fd5432a9dad7507f7eb9509

Anxiolytic-like Effects of the Positive GABAB Receptor Modulator GS39783 Correlate with Mice’s Individual Basal Anxiety and Stress Reactivity

Autor: Ahmet Oguzhan Bicakci, Mousumi Sarkar, Yu-Hsin Chang, Evelyn Kahl, Lorenzo Ragazzi, Angel Moldes-Anaya, Markus Fendt

Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 233 (2022)

Positive gamma-aminobutyric acid type B (GABAB) receptor modulators such as GS39783 have showed anxiolytic-like effects in several studies while such effects were absent in other studies. These conflicting findings led us hypothesize that the anxioly

Externí odkaz: https://doaj.org/article/721afe6aefe948699e007bed5a3340e3

The theranostic Goldilocks radionuclide copper-67 produced at a biomedical cyclotron

Autor: Ursula Søndergaard, Angel Moldes-Anaya, Kristina Pedersen, Rune Sundset, Mikael Jensen

Publikováno v: Nuclear Medicine and Biology. :S47-S48

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3b0760d6c1e16f8dc0d2656a50f9ec0
https://doi.org/10.1016/s0969-8051(22)02186-2

Glioblastoma PET/MRI: kinetic investigation of [18F]rhPSMA-7.3, [18F]FET and [18F]fluciclovine in an orthotopic mouse model of cancer

Autor: Marcel Lindemann, Ana Oteiza, Montserrat Martin-Armas, Yngve Guttormsen, Angel Moldes-Anaya, Rodrigo Berzaghi, Trond Velde Bogsrud, Tore Bach-Gansmo, Rune Sundset, Mathias Kranz

Publikováno v: Lindemann, M, Oteiza, A, Martin-Armas, M, Guttormsen, Y, Moldes-Anaya, A, Berzaghi, R, Bogsrud, T V, Bach-Gansmo, T, Sundset, R & Kranz, M 2023, ' Glioblastoma PET/MRI : kinetic investigation of [ 18 F]rhPSMA-7.3, [ 18 F]FET and [ 18 F]fluciclovine in an orthotopic mouse model of cancer ', European journal of nuclear medicine and molecular imaging, vol. 50, no. 4, pp. 1183-1194 . https://doi.org/10.1007/s00259-022-06040-z

Purpose Glioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is a potential target to image tumor microenvironment, as it defines its brain invasion. We investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695569f55370c5f051c0f08d3aa9e7d1
https://hdl.handle.net/10037/28555

Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons

Autor: Lorenzo Ragazzi, Ragnhild E. Paulsen, Hanne Friis Berntsen, Trude M. Haug, Rønnaug A.U. Strandabø, R. Andrew Tasker, Steven Verhaegen, Cesilie Granum Bjørklund, Angel Moldes-Anaya, Erik Ropstad

Publikováno v: Berntsen, H F, Moldes-Anaya, A, Bjørklund, C G, Ragazzi, L, Haug, T M, Strandabø, R A U, Verhaegen, S, Paulsen, R E, Ropstad, E & Tasker, R A 2020, ' Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons ', Toxicology, vol. 445, 152610 . https://doi.org/10.1016/j.tox.2020.152610
Toxicology

Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in consumer products. PFAAs cross th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ee47a7921e4a06bf2a19f454f61959
https://pubmed.ncbi.nlm.nih.gov/33027616