Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Angad Gothra"'
Autor:
Dana C. Borcherding, Neha V. Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Carina Dehner, Himanshi Bhatia, Angad Gothra, Layla Daud, Peter Ruminski, Christine A. Pratilas, Kai Pollard, Taylor Sundby, Brigitte C. Widemann, Angela C. Hirbe
Publikováno v:
Clinical Cancer Research. 29:1592-1604
Purpose: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases are associated with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6376177010a995b701dd6baf6516d887
https://doi.org/10.1158/1078-0432.ccr-22-3722
https://doi.org/10.1158/1078-0432.ccr-22-3722
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplemental Fig.S5. Validation of select gene expression changes with TYK2 inhibitor treatment that were identified by qPCR array. JH-2-002 cells were incubated with 40 µMWU-12 or control for 48 hours, and gene expression was analyzed by qPCR for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9731d69082d42fc007e50b47eee746df
https://doi.org/10.1158/1078-0432.22632929
https://doi.org/10.1158/1078-0432.22632929
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplemental Fig.S6. TYK2 inhibition decreases expression of STAT3 target genes and increases expression of genes in the MEK/MAPK signaling cascade in MPNST cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023561c63f48f29bba8f592400b71bcb
https://doi.org/10.1158/1078-0432.22632926
https://doi.org/10.1158/1078-0432.22632926
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Purpose:Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases are associated with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8930420b460dd667c263399c108f1bcc
https://doi.org/10.1158/1078-0432.c.6533056
https://doi.org/10.1158/1078-0432.c.6533056
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplemental Fig.S3. Genetic knockout of TYK2 blocks the effects of TYK2 inhibitors on proliferation in JW23.3 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8703e3bbd056a857daf304cb41107df1
https://doi.org/10.1158/1078-0432.22632935
https://doi.org/10.1158/1078-0432.22632935
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplemental Fig.S2. TYK2 inhibitors reduce proliferation and induce apoptosis in MPNST-724 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14d61d3ee0dbaf0a48982d7d370d40e
https://doi.org/10.1158/1078-0432.22632938
https://doi.org/10.1158/1078-0432.22632938
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplementary Table S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abab81da46462cc6120854cc7d2ae2bf
https://doi.org/10.1158/1078-0432.22632908.v1
https://doi.org/10.1158/1078-0432.22632908.v1
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplemental Fig.S7. The TYK2 inhibitor, WU-76, reduces activation of STAT3 while stimulating activation of ERK1/2 in MPNST cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5b44668efa27416ca696f884e86456
https://doi.org/10.1158/1078-0432.22632923
https://doi.org/10.1158/1078-0432.22632923
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplemental Fig.S1. Inhibition of TYK2 induces apoptosis in MPNST cell-lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffc8b41e62af8158fcbd00751fe9955
https://doi.org/10.1158/1078-0432.22632944.v1
https://doi.org/10.1158/1078-0432.22632944.v1
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplementary Table S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c04924d4527a90550890909a227f3c
https://doi.org/10.1158/1078-0432.22632911.v1
https://doi.org/10.1158/1078-0432.22632911.v1