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Autor: Pardhi, Triveni R., Karnik, Sadashiva S.

Publikováno v: Encyclopedia of Biological Chemistry III

The renin-angiotensin-aldosterone system (RAS) is a vital hormone-receptor system that regulates cardiovascular and renal functions. In this article, we discuss exciting new findings in the RAS field. Recently solved active state crystal structures o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::3640a46d59585f34c5342dd218f1c52a
http://europepmc.org/articles/PMC8326513

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Enhanced recombinant expression and purification of human IRAP for biochemical and crystallography studies

Autor: Hwai-Chen Guo, Lufei Sui

Publikováno v: Biochemistry and Biophysics Reports, Vol 27, Iss, Pp 101042-(2021)
Biochemistry and Biophysics Reports

Insulin-regulated aminopeptidase (IRAP) in humans is a membrane bound enzyme that has multiple functions. It was first described as a companion protein of the insulin-responsive glucose transporter, Glut4, in specialized vesicles. The protein has sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f29b661aba2326d9e75ff81058b7497
http://www.sciencedirect.com/science/article/pii/S2405580821001369

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Selective labeling of IRAP by the tritiated AT4 receptor ligand [3H]Angiotensin IV and its stable analog [3H]AL-11

Autor: Aneta Lukaszuk, Jean-Paul De Backer, Sridhara Chakravarthy, Géza Tóth, Dirk Tourwé, Erzsébet Szemenyei, Heidi Demaegdt, Yvette Michotte, Evi De Buyser, Georges Vauquelin, Mitradas M. Panicker

Publikováno v: Molecular and Cellular Endocrinology. 311:77-86

‘AT4 receptors’ through which Angiotensin IV (Ang IV) improves memory acquisition, were recently identified as insulin regulated aminopeptidase (IRAP). Radioligand binding studies have hitherto been performed with iodinated Ang IV in the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9d12c63cc2ed3178c7c2b7fc0c5e21
https://doi.org/10.1016/j.mce.2009.07.020

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Binding of 'AT receptor' ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells

Autor: Demaegdt, Heidi, Gard, Paul, De Backer, Jean-Paul, Lukaszuk, Aneta, Szemenyei, Erzsébet, Tóth, Géza, Tourwé, Dirk, Vauquelin, Georges

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2011, ⟨10.1016/j.mce.2011.03.005⟩

International audience; Insulin regulated aminopeptidase (IRAP) recognises "AT-receptor" ligands like angiotensin IV (Ang IV) and peptidomimetics like AL-11. The metabolic stability and high affinity of [H]AL-11 for catalytically active IRAP allowed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5aa84c1600f35968ec2dcb410e4d1519
https://hal.archives-ouvertes.fr/hal-00708531/file/PEER_stage2_10.1016%2Fj.mce.2011.03.005.pdf

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Binding of 'AT4 receptor' ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells

Autor: Aneta Lukaszuk, Dirk Tourwé, Paul R. Gard, Georges Vauquelin, Erzsébet Szemenyei, Jean-Paul De Backer, Heidi Demaegdt, Géza Tóth

Insulin regulated aminopeptidase (IRAP) recognises "AT(4)-receptor" ligands like angiotensin IV (Ang IV) and peptidomimetics like AL-11. The metabolic stability and high affinity of [(3)H]AL-11 for catalytically active IRAP allowed its detection in C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1938f3b146b8bea3fbdf624c084f1a
https://hdl.handle.net/20.500.14017/ca5c56cd-5efe-4b63-ba63-34efd096bbb2

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Selective labeling of IRAP by the tritiated AT receptor ligands [H]Angiotensin IV and its stable analog [H]AL-11

Autor: Demaegdt, Heidi, Lukaszuk, Aneta, De Buyser, Evi, De Backer, Jean-Paul, Szemenyei, Erzsébet, Tóth, Géza, Chakravarthy, Sridhara, Panicker, Mitradas, Michotte, Yvette, Tourwé, Dirk, Vauquelin, Georges

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2009, 311 (1-2), pp.77. ⟨10.1016/j.mce.2009.07.020⟩

International audience; ‘AT receptors' through which angiotensin IV (Ang IV) improves memory acquisition, were recently identified as insulin regulated aminopeptidase (IRAP). Radioligand binding studies have hitherto been performed with iodinated A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2e3cd55be8a7f400bf3a5d847163b909
https://hal.archives-ouvertes.fr/hal-00521552

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