Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Angélique B. van 't Wout"'
Autor:
Morgan S. A. Gilman, Polina Furmanova-Hollenstein, Gabriel Pascual, Angélique B. van ‘t Wout, Johannes P. M. Langedijk, Jason S. McLellan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The respiratory syncytial virus (RSV) F glycoprotein forms a trimeric complex and mediates viral entry. Using structures of RSV F in complex with antibodies, Gilman et al. here show a breathing motion of the prefusion conformation of F, resulting in
Externí odkaz:
https://doaj.org/article/9532301d0812415caee29f9be8ded047
Autor:
Xue-Song Zhang, Jackie Li, Kimberly A Krautkramer, Michelle Badri, Thomas Battaglia, Timothy C Borbet, Hyunwook Koh, Sandy Ng, Rachel A Sibley, Yuanyuan Li, Wimal Pathmasiri, Shawn Jindal, Robin R Shields-Cutler, Ben Hillmann, Gabriel A Al-Ghalith, Victoria E Ruiz, Alexandra Livanos, Angélique B van ‘t Wout, Nabeetha Nagalingam, Arlin B Rogers, Susan Jenkins Sumner, Dan Knights, John M Denu, Huilin Li, Kelly V Ruggles, Richard Bonneau, R Anthony Williamson, Marcus Rauch, Martin J Blaser
Publikováno v:
eLife, Vol 7 (2018)
The early-life intestinal microbiota plays a key role in shaping host immune system development. We found that a single early-life antibiotic course (1PAT) accelerated type 1 diabetes (T1D) development in male NOD mice. The single course had deep and
Externí odkaz:
https://doaj.org/article/5f77e81cd4e5448cbc2595e81c061fe1
Autor:
Harrison G Jones, Tina Ritschel, Gabriel Pascual, Just P J Brakenhoff, Elissa Keogh, Polina Furmanova-Hollenstein, Ellen Lanckacker, Jehangir S Wadia, Morgan S A Gilman, R Anthony Williamson, Dirk Roymans, Angélique B van 't Wout, Johannes P Langedijk, Jason S McLellan
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006935 (2018)
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants and the elderly, and yet there remains no effective treatment or vaccine. The surface of the virion is decorated with the fusion glycoprotein (
Externí odkaz:
https://doaj.org/article/934d8568511a4a31a4fe4f3f7569d4dc
Autor:
Thijs Booiman, Vladimir V Loukachov, Karel A van Dort, Angélique B van 't Wout, Neeltje A Kootstra
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144229 (2015)
Transcription of the HIV-1 provirus is regulated by both viral and host proteins and is very important in the context of viral latency. In latently infected cells, viral gene expression is inhibited as a result of the sequestration of host transcript
Externí odkaz:
https://doaj.org/article/5fad737902604a6d9f715af2e1ec1346
Autor:
Thijs Booiman, Viviana Cobos Jiménez, Karel A van Dort, Angélique B van 't Wout, Neeltje A Kootstra
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109673 (2014)
BACKGROUND:HIV-1 infected macrophages play a key role in HIV-1 infection. Even during anti-retroviral treatment, macrophages keep producing virus due to suboptimal tissue penetration and reduced efficacy of antiretrovirals. It is therefore of major i
Externí odkaz:
https://doaj.org/article/6a9a382fabd644cf806f66ec2f23b193
Autor:
Esther F Gijsbers, Ard van Sighem, Agnes M Harskamp, Matthijs R A Welkers, Frank de Wolf, Kees Brinkman, Jan M Prins, Hanneke Schuitemaker, Angélique B van 't Wout, Neeltje A Kootstra
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76255 (2013)
The emergence of CXCR4-using HIV variants (X4-HIV) is associated with accelerated disease progression in the absence of antiretroviral therapy. However, the effect of X4-HIV variants on the treatment response remains unclear. Here we determined wheth
Externí odkaz:
https://doaj.org/article/ab7bf1538ea1427ca4b2da5f4ed86898
Autor:
Martijn J Stax, Neeltje A Kootstra, Angélique B van 't Wout, Michael W T Tanck, Margreet Bakker, Georgios Pollakis, William A Paxton
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32534 (2012)
BackgroundDC-SIGN expressed by dendritic cells captures HIV-1 resulting in trans-infection of CD4(+) T-lymphocytes. However, BSSL (bile-salt stimulated lipase) binding to DC-SIGN interferes with HIV-1 capture. DC-SIGN binding properties of BSSL assoc
Externí odkaz:
https://doaj.org/article/e420b8d6bfe94ac2bf25aa55f32116cc
Autor:
Art F Y Poon, Luke C Swenson, Evelien M Bunnik, Diana Edo-Matas, Hanneke Schuitemaker, Angélique B van 't Wout, P Richard Harrigan
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 11, p e1002753 (2012)
At the early stage of infection, human immunodeficiency virus (HIV)-1 predominantly uses the CCR5 coreceptor for host cell entry. The subsequent emergence of HIV variants that use the CXCR4 coreceptor in roughly half of all infections is associated w
Externí odkaz:
https://doaj.org/article/67f567acd2e642d6b7c2cbf1aac1c063
Autor:
Sebastiaan M Bol, Thijs Booiman, Daniëlle van Manen, Evelien M Bunnik, Ard I van Sighem, Margit Sieberer, Brigitte Boeser-Nunnink, Frank de Wolf, Hanneke Schuitemaker, Peter Portegies, Neeltje A Kootstra, Angélique B van 't Wout
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30990 (2012)
BACKGROUND: Infection with HIV-1 may result in severe cognitive and motor impairment, referred to as HIV-1-associated dementia (HAD). While its prevalence has dropped significantly in the era of combination antiretroviral therapy, milder neurocogniti
Externí odkaz:
https://doaj.org/article/39162ba0da244103989f1c69d89be247
Autor:
Michael Vieth, Pim J. Koelink, Larry Stitt, Brian G. Feagan, Suzanne Duijst, Geert R. D'Haens, Angélique B van ‘t Wout, Raja Atreya, Johannan F. Brandse, Anje A. te Velde, Martin Koldijk, Gijs R. van den Brink, Manon E. Wildenberg, Barrett G. Levesque
Publikováno v:
Journal of Crohn s & colitis, 12(7), 794-803. Elsevier
Journal of Crohn's & Colitis
Journal of Crohn's & Colitis
Background and Aims Although several endoscopic and histopathologic indices are available for evaluating the severity of inflammation in mouse models of colitis, the reliability of these scoring instruments is unknown. Our aim was to evaluate the rel