Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells

Autor: Anaïs Moulin, Irène Aksoy, Manon Dirheimer, Thierry Joly, Guillaume Marcy, Florence Wianny, Pierre-Yves Bourillot, Chloé Mayère, Olivier Raineteau, Marielle Afanassieff, Cian J. Lynch, Angèle Bellemin-Ménard, Véronique Cortay, Nathalie Doerflinger, Etienne Masfaraud, Manuel Serrano, Pierre Savatier, Colette Dehay, Cloé Rognard

Publikováno v: Stem Cell Reports
Stem Cell Reports, Elsevier, 2021, 16 (1), pp.56-74. ⟨10.1016/j.stemcr.2020.12.004⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Stem Cell Reports, 2021, 16 (1), pp.56-74. ⟨10.1016/j.stemcr.2020.12.004⟩

Summary After reprogramming to naive pluripotency, human pluripotent stem cells (PSCs) still exhibit very low ability to make interspecies chimeras. Whether this is because they are inherently devoid of the attributes of chimeric competency or becaus

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https://hal.inrae.fr/hal-03341220