Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Autor: Perry, JRB, Day, F, Elks, CE, Sulem, P, Thompson, DJ, Ferreira, T, He, C, Chasman, DI, Esko, T, Thorleifsson, G, Albrecht, E, Ang, WQ, Corre, T, Cousminer, DL, Feenstra, B, Franceschini, N, Ganna, A, Johnson, AD, Kjellqvist, S, Lunetta, KL, McMahon, G, Nolte, IM, Paternoster, L, Porcu, E, Smith, AV, Stolk, L, Teumer, A, Tšernikova, N, Tikkanen, E, Ulivi, S, Wagner, EK, Amin, N, Bierut, LJ, Byrne, EM, Hottenga, JJ, Koller, DL, Mangino, M, Pers, TH, Yerges-Armstrong, LM, Zhao, JH, Andrulis, IL, Anton-Culver, H, Atsma, F, Bandinelli, S, Beckmann, MW, Benitez, J, Blomqvist, C, Bojesen, SE, Bolla, MK, Bonanni, B, Brauch, H, Brenner, H, Buring, JE, Chang-Claude, J, Chanock, S, Chen, J, Chenevix-Trench, G, Collée, JM, Couch, FJ, Couper, D, Coviello, AD, Cox, A, Czene, K, D'adamo, AP, Smith, GD, De Vivo, I, Demerath, EW

Publikováno v: Perry, JRB; Day, F; Elks, CE; Sulem, P; Thompson, DJ; Ferreira, T; et al.(2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514(7520), 92-97. doi: 10.1038/nature13545. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0n12h1nf

© 2014 Macmillan Publishers Limited. All rights reserved. Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascul

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http://www.escholarship.org/uc/item/0n12h1nf

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.

Autor: Macé A; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.; Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland., Tuke MA; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Deelen P; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.; University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, 9713 GZ, The Netherlands., Kristiansson K; National Institute for Health and Welfare, Helsinki, 00271, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, FI-00014, Finland., Mattsson H; National Institute for Health and Welfare, Helsinki, 00271, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, FI-00014, Finland., Nõukas M; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu, 51010, Estonia., Sapkota Y; QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia.; St. Jude Children's Research hospital, Memphis, TN, 38105, USA., Schick U; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Porcu E; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.; Center for Integrative Genomics, University of Lausanne, Lausanne, 1015, Switzerland., Rüeger S; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., McDaid AF; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Porteous D; Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, 93053, Germany., Salvi E; Department of Health Sciences, University of Milano, Milano, 20090, Italy., Shrine N; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK., Liu X; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2300, Denmark., Ang WQ; School of Women's and Infants' Health, The University of Western Australia, Perth, 6009, Australia., Zhang W; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3EU, UK., Feitosa MF; Department of Genetics, Washington University School of Medicine, St. Louis, 63108, USA., Venturini C; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands., Rosengren A; Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Roskilde, 4000, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, 8210, Denmark., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Beaumont RN; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Jones SE; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Ruth KS; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Tyrrell J; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Havulinna AS; National Institute for Health and Welfare, Helsinki, 00271, Finland., Boers H; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.; University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, 9713 GZ, The Netherlands., Mägi R; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Kriebel J; Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Muenchen-Neuherberg, 85764, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Department of Medicine I, Ludwig-Maximilians-Universität, Munich, 81337, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, 80336, Germany., Perola M; National Institute for Health and Welfare, Helsinki, 00271, Finland.; University of Tartu, Estonian Genome Center, Tartu, 51010, Estonia., Nieminen M; Heart and Lung Centre HUCH and Helsinki University, Helsinki, 00029, Finland., Lokki ML; Medicum, Helsinki University, Helsinki, 00014, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland.; Department of Clinical Physiology, University of Tampere Faculty of Medicine and Life Sciences, Tampere, 33521, Finland., Viikari JS; Division of Medicine, Turku University Hospital, Turku, 20521, Finland.; Department of Medicine, University of Turku, Turku, 20521, Finland., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2300, Denmark., Lahti J; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.; Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, 00014, Finland., Palotie A; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, FI-00014, Finland.; The Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Analytic and Translational Genetics Unit, Department of Medicine and Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA., Koponen P; National Institute for Health and Welfare, Helsinki, 00271, Finland., Lundqvist A; National Institute for Health and Welfare, Helsinki, 00271, Finland., Rissanen H; National Institute for Health and Welfare, Helsinki, 00271, Finland., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Afaq S; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK., Wojczynski MK; Department of Genetics, Washington University School of Medicine, St. Louis, 63108, USA., Lenzini P; Department of Genetics, Washington University School of Medicine, St. Louis, 63108, USA., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands., Sparsø T; Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Roskilde, 4000, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, 8210, Denmark., Schupf N; Taub Institute, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA., Christensen K; The Danish Aging Research Center, Epidemiology, University of Southern Denmark, Odense, 5000, Denmark., Perls TT; Section of Geriatrics, Department of Medicine, Boston University, Boston School of Medicine and Boston Medical Center, Boston, MA, 02118, USA., Newman AB; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, 15261, USA., Werge T; Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Roskilde, 4000, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, 8210, Denmark.; Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3EU, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Koskinen S; National Institute for Health and Welfare, Helsinki, 00271, Finland., Melbye M; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2300, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, 2200, Denmark.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20521, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33521, Finland.; Department of Clinical Chemistry, University of Tampere Faculty of Medicine and Life Sciences, Tampere, 33521, Finland., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK.; National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK., Wain LV; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK.; National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK., Sinisalo J; Heart and Lung Centre HUCH and Helsinki University, Helsinki, 00029, Finland., Peters A; Institute of Epidemiology II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Muenchen-Neuherberg, 85764, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, 80336, Germany., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, 85764, Germany.; Institute of Human Genetics, Technische Universität München, Munich, 81675, Germany., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Wray NR; Queensland Brain Institute, University of Queensland, Brisbane, QLD, 4072, Australia., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia.; The Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia., Swertz MA; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.; University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, 9713 GZ, The Netherlands., Vartiainen E; National Institute for Health and Welfare, Helsinki, 00271, Finland., Borodulin K; National Institute for Health and Welfare, Helsinki, 00271, Finland., Männistö S; National Institute for Health and Welfare, Helsinki, 00271, Finland., Murray A; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Bochud M; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland., Jacquemont S; Centre de recherche, Centre Hospitalier Universitaire Sainte Justine, Montréal, Canada, H3T 1C5.; Service of Medical Genetics, University Hospital of Lausanne, University of Lausanne, Lausanne, 1011, Switzerland., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Hansen TF; Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Roskilde, 4000, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, 8210, Denmark., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, SE1 9RT, UK., Province MA; Department of Genetics, Washington University School of Medicine, St. Louis, 63108, USA., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Kooner JS; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3EU, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK.; National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., Freathy RM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Pennell C; School of Women's and Infants' Health, The University of Western Australia, Perth, 6009, Australia., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2300, Denmark., Strachan DP; Population Health Research Institute, St. George's, University of London, London, SW17 0RE, UK., Lettre G; Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada, H1T 1C8.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada, H3T 1J4., Hirschhorn J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA., Cusi D; Department of Health Sciences, University of Milano, Milano, 20090, Italy.; Institute of Biomedical Technologies, Italian National Research Council, Milano, 20090, Italy., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, 93053, Germany., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Männik K; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Center for Integrative Genomics, University of Lausanne, Lausanne, 1015, Switzerland., Beckmann JS; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, 10029, USA., Nyholt DR; QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, 4059, Australia., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, 00014, Finland.; Folkhälsan Research Center, Helsinki, 00250, Finland., Weedon MN; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Salomaa V; National Institute for Health and Welfare, Helsinki, 00271, Finland., Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands., Reymond A; Center for Integrative Genomics, University of Lausanne, Lausanne, 1015, Switzerland., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Kutalik Z; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland. zoltan.kutalik@unil.ch.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland. zoltan.kutalik@unil.ch.

Publikováno v: Nature communications [Nat Commun] 2017 Sep 29; Vol. 8 (1), pp. 744. Date of Electronic Publication: 2017 Sep 29.

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Autor: Perry JR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; University of Exeter Medical School, University of Exeter, Exeter, UK EX1 2LU.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Day F; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Elks CE; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Sulem P; deCODE Genetics, Reykjavik, Iceland., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., He C; Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA.; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.; Harvard Medical School, Boston, MA 02115., Esko T; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Ang WQ; School of Women's and Infants' Health, The University of Western Australia., Corre T; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Cousminer DL; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC., Ganna A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Johnson AD; NHLBI's and Boston University's Framingham Heart Study, Framingham, MA., Kjellqvist S; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden., Lunetta KL; NHLBI's and Boston University's Framingham Heart Study, Framingham, MA.; Boston University School of Public Health, Department of Biostatistics. Boston, MA., McMahon G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Paternoster L; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Porcu E; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.; University of Sassari, Dept. Of Biomedical Sciences, Sassari, Italy., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; University of Iceland, Reykjavik, Iceland., Stolk L; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Teumer A; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany., Tšernikova N; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Department of Biotechnology, University of Tartu, Tartu, 51010, Estonia., Tikkanen E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.; Hjelt Institute, University of Helsinki, Finland., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' - Trieste, Italy., Wagner EK; Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA.; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA., Amin N; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Bierut LJ; Dept. of Psychiatry, Washington University, St. Louis, MO 63110., Byrne EM; The University of Queensland, Queensland Brain Institute, St.Lucia, QLD, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Hottenga JJ; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands., Koller DL; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Pers TH; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, US.; Center for Biological Sequence Analysis, Department of Systems Biology, Technical 142 University of Denmark, Lyngby 2800, Denmark., Yerges-Armstrong LM; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Andrulis IL; Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Anton-Culver H; Department of Epidemiology, University of California Irvine, Irvine, California, USA., Atsma F; Sanquin Research, Nijmegen, The Netherlands., Bandinelli S; Tuscany Regional Health Agency, Florence, Italy, I.O.T. and Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy.; Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy., Beckmann MW; University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Benitez J; Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain., Blomqvist C; Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Bojesen SE; Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark., Bolla MK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Bonanni B; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy., Brauch H; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart.; University of Tübingen, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.; Harvard Medical School, Boston, MA 02115., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Chanock S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Chen J; Departments of Anatomy and Neurological Surgery, Indiana University school of Medicine, Indianapolis, IN 46202, USA.; Stark Neuroscience Research Center, Indiana University school of Medicine, Indianapolis, IN 46202, USA., Chenevix-Trench G; Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Collée JM; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands., Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Couper D; Department of Biostatistics, University of North Carolina, Chapel Hill, NC., Coveillo AD; Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA., Cox A; Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK., Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., D'adamo AP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' - Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Italy., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., De Vivo I; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Demerath EW; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minn., USA., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Devilee P; Department of Human Genetics & Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Dieffenbach AK; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Eriksson JG; National Institute for Health and Welfare, Finland.; Department of General Practice and Primary health Care, University of Helsinki, Finland.; Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.; Folkhalsan Research Centre, Helsinki, Finland., Fasching PA; University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Ferrucci L; Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America., Flesch-Janys D; Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany., Flyger H; Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Foroud T; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana USA., Franke L; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands., Garcia ME; National Insitute on Aging, National Institutes of Health, Baltimore, MD 20892, USA., García-Closas M; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.; Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK., Geller F; Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark., de Geus EE; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.; EMGO + Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081 Bt, Amsterdam, The Netherlands., Giles GG; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Gudbjartsson DF; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; University of Iceland, Reykjavik, Iceland., Guénel P; Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.; University Paris-Sud, UMRS 1018, Villejuif, France., Guo S; Department of Obstetrics and Gynecology, Southern Medical University, Guangzhou, China., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Hamann U; Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany., Haring R; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Heath AC; Washington University, Department of Psychiatry, St.Louis, Missouri, USA., Hofman A; Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands., Hooning MJ; Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Hu FB; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA., Hunter DJ; Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Karasik D; Harvard Medical School, Boston, MA 02115.; Hebrew SeniorLife Institute for Aging Research, Boston, MA., Kiel DP; Hebrew SeniorLife Institute for Aging Research, Boston, MA.; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115., Knight JA; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Kosma VM; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Kutalik Z; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Lai S; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy., Lambrechts D; Vesalius Research Center (VRC), VIB, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Mägi R; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Mannermaa A; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Martin NG; Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Masson G; deCODE Genetics, Reykjavik, Iceland., McArdle PF; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201., McArdle WL; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Melbye M; Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark.; Department of Medicine, Stanford School of Medicine, Stanford, USA., Michailidou K; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Department of Biotechnology, University of Tartu, Tartu, 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Milne RL; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Neven P; KULeuven (University of Leuven), Department of Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Belgium., Nohr EA; Research Unit of Obstetrics & Gynecology, Institute of Clinical Research, University of Southern denmark, DK., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Oostra BA; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Peacock M; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Peterlongo P; IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy., Peto J; Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK., Pharoah PD; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK., Postma DS; University Groningen, University Medical Center Groningen, Department Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, Groningen, The Netherlands., Pouta A; National Institute for Health and Welfare, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Finland., Pylkäs K; Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, Oulu, Finland., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Ring S; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Rivadeneira F; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' - Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Italy., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215., Rudolph A; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Salomaa V; National Institute for Health and Welfare, Finland., Sanna S; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy., Schlessinger D; National Institute on Aging, Intramural Research Program, Baltimore, MD, USA., Schmidt MK; Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands., Southey MC; Department of Pathology, The University of Melbourne, Melbourne, Australia., Sovio U; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.; Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, United Kingdom., Stampfer MJ; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA., Stöckl D; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig-Maximilians- University, Munich, Germany., Storniolo AM; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana USA., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Tyrer J; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK., Visser JA; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Vollenweider P; Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland., Völzke H; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany., Waeber G; Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Wallaschofski H; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany., Wang Q; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Willemsen G; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands., Winqvist R; Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, Oulu, Finland., Wolffenbuttel BH; Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands., Wright MJ; Queensland Insitute of Medical Research, Brisbane, Queensland, Australia., Boomsma DI; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands., Econs MJ; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana USA.; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana USA., Khaw KT; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB2 0QQ, UK., Loos RJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1003, New York, NY 10029, USA., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE Oxford, UK.; Oxford Centre for Diabetes, Endocrinology, & Metabolism, University of Oxford, Churchill Hospital, OX37LJ Oxford, UK., Montgomery GW; Queensland Insitute of Medical Research, Brisbane, Queensland, Australia., Rice JP; Dept. of Psychiatry, Washington University, St. Louis, MO 63110., Streeten EA; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201.; Geriatric Research and Education Clinical Center (GRECC) - Veterans Administration Medical Center, USA. Baltimore, MD 21201., Thorsteinsdottir U; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., van Duijn CM; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Centre of Medical Systems Biology, Leiden, the Netherlands., Alizadeh BZ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Bergmann S; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Boerwinkle E; Human Genetics Center and Div. of Epidemiology, University of Houston, TX., Boyd HA; Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark., Crisponi L; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy., Gasparini P; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' - Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Italy., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Harris TB; National Insitute on Aging, National Institutes of Health, Baltimore, MD 20892, USA., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Järvelin MR; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.; Institute of Health Sciences, P.O.Box 5000, FI-90014 University of Oulu, Finland.; Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.; Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220 Oulu, 90029 OYS, Finland., Kraft P; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA., Lawlor D; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Department of Biotechnology, University of Tartu, Tartu, 51010, Estonia., Pennell CE; School of Women's and Infants' Health, The University of Western Australia., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.; Harvard Medical School, Boston, MA 02115., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Sørensen TI; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Strachan DP; Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK., Uitterlinden AG; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Widen E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland., Zygmunt M; Department of Obstetrics and Gynecology, University Medicine Greifswald, 17475 Greifswald, Germany., Murray A; University of Exeter Medical School, University of Exeter, Exeter, UK EX1 2LU., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Murabito JM; NHLBI's and Boston University's Framingham Heart Study, Framingham, MA.; Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Department of Paediatrics,University of Cambridge,Cambridge,UK.

Publikováno v: Nature [Nature] 2014 Oct 02; Vol. 514 (7520), pp. 92-97. Date of Electronic Publication: 2014 Jul 23.

Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity.

Autor: Adams LA; School of Medicine and Pharmacology, The University of Western Australia (UWA), Australia. leon.adams@uwa.edu.au, Marsh JA, Ayonrinde OT, Olynyk JK, Ang WQ, Beilin LJ, Mori T, Palmer LJ, Oddy WW, Lye SJ, Pennell CE

Publikováno v: Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2012 Sep; Vol. 27 (9), pp. 1520-7.