Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anfal S. Aljahdali"'
Autor:
Afaf A. El-Malah, Magdy M. Gineinah, Maan T. Khayat, Anfal S. Aljahdali, Marwa M. Safar, Hadeel A. Almazmumi, Roaa M. Khinkar
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)-specific PDE that is expressed in immune and proinflammatory cells. In this work, we explore the possibility that selective small molecule inhibitors of this enzyme family
Externí odkaz:
https://doaj.org/article/217017829d4d45538e0140485c4c4db3
Autor:
Abdelsattar M. Omar, Anfal S. Aljahdali, Martin K. Safo, Gamal A. Mohamed, Sabrin R. M. Ibrahim
Publikováno v:
Molecules, Vol 28, Iss 1, p 44 (2022)
Cannabinoid receptor ligands are renowned as being therapeutically crucial for treating diverse health disorders. Phenylspirodrimanes are meroterpenoids with unique and varied structural scaffolds, which are mainly reported from the Stachybotrys genu
Externí odkaz:
https://doaj.org/article/085c7fb905644721ac2dda00d83e520b
Autor:
Afaf A. El-Malah, Magdy M. Gineinah, Pran Kishore Deb, Ahdab N. Khayyat, Monika Bansal, Katharigatta N. Venugopala, Anfal S. Aljahdali
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 827 (2022)
The introduction of selective COX-2 inhibitors (so-called ‘coxibs’) has demonstrated tremendous commercial success due to their claimed lower potential of serious gastrointestinal adverse effects than traditional NSAIDs. However, following the re
Externí odkaz:
https://doaj.org/article/8c7629413e8f42de88fed1fd3dfed592
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7448 (2022)
Sickle cell disease (SCD) is a genetic disorder that affects millions of individuals worldwide. Chronic anemia, hemolysis, and vasculopathy are associated with SCD, and their role has been well characterized. These symptoms stem from hemoglobin (Hb)
Externí odkaz:
https://doaj.org/article/3c3156501dff4c92ae176f8e0ba77a4b
Autor:
Maan T. Khayat, Hany E. A. Ahmed, Abdelsattar M. Omar, Yosra A. Muhammad, Khadijah A. Mohammad, Azizah M. Malebari, Ahdab N. Khayyat, Ahmed H. Halawa, Hamada S. Abulkhair, Ahmed A. Al-Karmalawy, Mohammed Almaghrabi, Majed Alharbi, Anfal S. Aljahdali, Ahmed M. El-Agrody
Publikováno v:
Journal of Biomolecular Structure and Dynamics. :1-19
All the previously reported phenylpyrazoles as carbonic anhydrase inhibitors (CAIs) were found to have small sizes and high levels of flexibility, and hence showed low selectivity profiles toward a particular isoform of CA. Herein, we report the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7d76b8f65077cdfe75d2d84f242b04
https://doi.org/10.1080/07391102.2023.2188957
https://doi.org/10.1080/07391102.2023.2188957
Autor:
Anfal S. Aljahdali, Faik N. Musayev, John W. Burgner, Mohini S. Ghatge, Vibha Shekar, Yan Zhang, Abdelsattar M. Omar, Martin K. Safo
Publikováno v:
Acta Crystallographica Section D Structural Biology. 78:472-482
Bisphosphoglycerate mutase (BPGM) is an erythrocyte-specific multifunctional enzyme that is responsible for the regulation of 2,3-bisphosphoglycerate (2,3-BPG) in red blood cells through its synthase and phosphatase activities; the latter enzymatic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd22cc0a33fa0732bd83c045ad82f58
https://doi.org/10.1107/s2059798322001802
https://doi.org/10.1107/s2059798322001802