The VWRPY Domain Is Essential for RUNX1 Function in Hematopoietic Progenitor Cell Maturation and Megakaryocyte Differentiation

Autor: April D. Sorrell, Tao Zhen, Halah Alkadi, Linzhao Cheng, Tatiana S. Karpova, David McKellar, Lisa Garrett, David A. Ball, Paul P. Liu, Erika Mijin Kwon, Anfal A Alsadhan, Yongxing Gao, James J. Greene

Publikováno v: Blood. 132:1319-1319

RUNX1 is a transcription factor essential during definitive hematopoiesis. Germline mutations in RUNX1 results in a disorder called Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM). FPDMM patients have abnormal bleeding due to re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d18c294ba32d7eebc957f60de2bcf3b
https://doi.org/10.1182/blood-2018-99-113400

CD49d Expression Identifies a Biologically Distinct Subtype of Chronic Lymphocytic Leukemia with Inferior Progression-Free Survival on BTK Inhibitor Therapy.

Autor: Alsadhan A; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.; Catholic University of America, Washington, DC.; College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia., Chen J; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Gaglione EM; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Underbayev C; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Tuma PL; Catholic University of America, Washington, DC., Tian X; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Freeman LA; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Baskar S; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Nierman P; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Soto S; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Itsara A; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Ahn IE; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Sun C; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Bibikova E; AstraZeneca South San Francisco, California., Hartmann TN; Department of Medicine I, Medical Center-University, Faculty of Medicine of Freiburg, Freiburg, Germany., Mhibik M; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Wiestner A; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Sep 15; Vol. 29 (18), pp. 3612-3621.