Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anette Von Matt"'
Autor:
Nicolas Soldermann, Ian Lewis, Alexander Baxter Smith, Klemens Hoegenauer, Frédéric Zecri, Dorothea Haasen, Anette Von Matt, Gregory Hollingworth, Christoph Burkhart, Christina Hebach, Rainer Wilcken, Romain M. Wolf
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5657-5662
In the recent years, PI3Kδ has emerged as a promising target for the treatment of B- and T-cell mediated inflammatory diseases. We present a cellular assay activity analysis for our previously reported 4,6-diaryl quinazoline PI3Kδ inhibitor series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2d9d71e823031bb6f22f69b819f64c
https://doi.org/10.1016/j.bmcl.2016.10.069
https://doi.org/10.1016/j.bmcl.2016.10.069
Autor:
Anette Von Matt, Wilhelm Stark, Christoph Gaul, Juergen Wagner, Eric Vangrevelinghe, Lauren G. Monovich, Gabriele Rummel, Nicolas Soldermann, Walter Schuler, André Strauss, Sandra W. Cowan-Jacob, Maurice Van Eis, Jean-Pierre Evenou, Philipp Floersheim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7367-7372
The present study describes a novel series of ATP-competitive PKC inhibitors based on the 2,6-naphthyridine template. Example compounds potently inhibit the novel Protein Kinase C (PKC) isotypes δ, ε, η, θ (in particular PKCε/η, and display a 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a049780df31bdb8fa0ca7b096755c8fe
https://doi.org/10.1016/j.bmcl.2011.10.025
https://doi.org/10.1016/j.bmcl.2011.10.025
Autor:
Jie Shi, Vinayak Hosagrahara, Keith A. Koch, Lihua Yang, Dillon Phan, Hansjoerg Lehmann, Ophelia Ardayfio, Olga Rozhitskaya, Sarah Siska, Maurice Van Eis, Ming Qian, Taeyoung Yoon, Timothy A. McKinsey, Kimberly Beattie, Craig F. Plato, Lauren G. Monovich, Clayton Springer, Margaret R. Pancost, Anup Patnaik, Erik Meredith, Ji-Hu Zhang, Istvan J. Enyedy, Anette Von Matt, Vasumathy Rajaraman, Richard B. Vega, Wendy Lee, Nikos Pagratis, Karl Miranda, Christoph Gaul, Markus Dobler, Chang Rao, Thomas Ruppen, Na Zhu, Charles F. Jewell
Publikováno v:
Journal of Medicinal Chemistry. 53:5400-5421
A novel 2,6-naphthyridine was identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor. PKD inhibition in the heart was proposed as a potential antihypertrophic mechanism with application as a heart failure therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643c1eb2e5cd66e32ad8af6e6eca9317
https://doi.org/10.1021/jm100075z
https://doi.org/10.1021/jm100075z
Autor:
Sandra W. Cowan-Jacob, Keiichi Masuya, Bernard Pirard, Nina Gommermann, Werner Breitenstein, Gisbert Weckbecker, Peter Buehlmayer, Pascal Furet, Anette Von Matt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3628-3631
A novel series of pyrazolo[1,5a]pyrimidines was optimized to target lymphocyte-specific kinase (Lck). An efficient synthetic route was developed and SAR studies toward activity and selectivity are described, leading to Lck inhibitors with enzymatic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4924c5a9fa84f96f5defd89cfb121c7a
https://doi.org/10.1016/j.bmcl.2010.04.112
https://doi.org/10.1016/j.bmcl.2010.04.112
Autor:
Christian Beerli, Thai Than, Joanne Joergensen, Andrea Florineth, Gisbert Weckbecker, Anette Von Matt, Christos Papageorgiou, Xaver Borer, Elsebeth Andersen, Gretty Rihs, Christoph Heusser, Max H. Schreier, Katrin Wagner
Publikováno v:
Journal of Medicinal Chemistry. 44:1986-1992
The prevention of xenograft rejection is substantially dependent on inhibiting antibodies (Ab) produced by B-cells independently of T-cell signals (TI-1). Due to their ubiquitous biochemical mechanisms of action, the immunosuppressants currently empl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da14efbac9eeb3c747a03050217c3776
https://doi.org/10.1021/jm010822m
https://doi.org/10.1021/jm010822m
Autor:
Malcolm D. Walkinshaw, Carlo Tapparelli, Anette Von Matt, Claus Ehrhardt, Peter Burkhard, Rainer Metternich
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:2291-2303
Based on the structural comparison of the S1 pocket in different trypsin-like serine proteases, a series of Boc-D-trimethylsilylalanine-proline-boro-X pinanediol derivatives, with boro-X being different amino boronic acids, have been synthesized as i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f19c6b26be8ed83e125634bce60027
https://doi.org/10.1016/s0968-0896(00)00147-4
https://doi.org/10.1016/s0968-0896(00)00147-4
Autor:
Anette Von Matt, Werner Breitenstein, Keiichi Masuya, Gisbert Weckbecker, Peter Buehlmayer, Sandra W. Cowan-Jacob, Bernard Pirard, Pascal Furet, Nina Gommermann
Publikováno v:
ChemInform. 41
Reaction of acid chlorides (VI) or chloroformates (VIII) with key intermediate (V) affords a new series of pyrazolopyrimidines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86d81a29f7886cf276fed293418dbfce
https://doi.org/10.1002/chin.201047153
https://doi.org/10.1002/chin.201047153