Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Anette Sundstedt"'
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Akademický článek
Tolerogenic dendritic cells generated in vitro using a novel protocol mimicking mucosal tolerance mechanisms represent a potential therapeutic cell platform for induction of immune tolerance
Autor: Gillian Dao Nyesiga, Lieneke Pool, Pavlos C. Englezou, Terese Hylander, Lars Ohlsson, Daniel Appelgren, Anette Sundstedt, Kristina Tillerkvist, Hanne R. Romedahl, Maria Wigren
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Dendritic cells (DCs) are mediators between innate and adaptive immunity and vital in initiating and modulating antigen-specific immune responses. The most important site for induction of tolerance is the gut mucosa, where TGF-β, retinoic acid, and
Externí odkaz: https://doaj.org/article/f2c2984fc5da4eb8b7fc390b4c372a1e
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3
Akademický článek
Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies
Autor: Malin Lindstedt, Peter Ellmark, Lennart Greiff, Karin Hägerbrand, Laura von Schantz, Mia Thagesson, Doreen Werchau, Kristine Smedenfors, Anna Rosén, Anette Sundstedt, Adnan Deronic, Lill Ljung, Mattias Levin, Laura Varas, Anna Säll, Christina Sakellariou, Barnabas Nyesiga, David Gomez Jimenez, Mona Celander, Deniz Bölükbas, Fredrika Carlsson
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen pr
Externí odkaz: https://doaj.org/article/3ded16f9cf504c5983b33e362b58d5fd
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6
Akademický článek
The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.
Autor: Gunnar Hedlund, Helena Eriksson, Anette Sundstedt, Göran Forsberg, Bent K Jakobsen, Nicholas Pumphrey, Karin Rödström, Karin Lindkvist-Petersson, Per Björk
Publikováno v: PLoS ONE, Vol 8, Iss 10, p e79082 (2013)
The T lymphocytes are the most important effector cells in immunotherapy of cancer. The conceptual objective for developing the tumor targeted superantigen (TTS) ABR-217620 (naptumomab estafenatox, 5T4Fab-SEA/E-120), now in phase 3 studies for advanc
Externí odkaz: https://doaj.org/article/7714f2df1eeb429698d214d001f27ccb
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