Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Anette M, Johansson"'
Autor:
Robert F. Bruns, Qi Chen, Paloma Vidal, John Mehnert Schaus, Charles R. Yang, Stephen N. Mitchell, Steven Marc Massey, Nuria Diaz, Xushan Wang, David Andrew Coates, Rebecca A. Wright, Beverly A. Heinz, Kevin Matthew Gardinier, Greg Stephenson, James P. Beck, Rajni M. Bhardwaj, Julie F. Falcone, Bruce A. Dressman, Deanna L Maren, Anette M. Johansson, David Michael Remick, Jeff W. Cramer, Cohen Michael Philip, Brian Morgan Watson, Jeffery Richardson, Kjell Svensson, Xin Zhou, Erik James Hembre, Serge Louis Boulet, Reinhard Matthew Robert, Daniel S. Richards, Junliang Hao, David M. Bender, Guy Carter, Christopher David Beadle, Brian G. Getman, Wolfangel Craig Daniel, Diseroad Benjamin Alan, Jason K. Myers, Joseph H. Krushinski, David Edward Tupper
Publikováno v:
Journal of Medicinal Chemistry. 62:8711-8732
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a353395d3c6f7ca6dfa78c95a347dd4
https://doi.org/10.1021/acs.jmedchem.9b01234
https://doi.org/10.1021/acs.jmedchem.9b01234
Autor:
Junliang, Hao, James P, Beck, John M, Schaus, Joseph H, Krushinski, Qi, Chen, Christopher D, Beadle, Paloma, Vidal, Matthew R, Reinhard, Bruce A, Dressman, Steven M, Massey, Serge L, Boulet, Michael P, Cohen, Brian M, Watson, David, Tupper, Kevin M, Gardinier, Jason, Myers, Anette M, Johansson, Jeffery, Richardson, Daniel S, Richards, Erik J, Hembre, David M, Remick, David A, Coates, Rajni M, Bhardwaj, Benjamin A, Diseroad, David, Bender, Greg, Stephenson, Craig D, Wolfangel, Nuria, Diaz, Brian G, Getman, Xu-Shan, Wang, Beverly A, Heinz, Jeff W, Cramer, Xin, Zhou, Deanna L, Maren, Julie F, Falcone, Rebecca A, Wright, Stephen N, Mitchell, Guy, Carter, Charles R, Yang, Robert F, Bruns, Kjell A, Svensson
Publikováno v:
Journal of medicinal chemistry. 62(19)
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38771cd6f379be26a1a0dc76826df19b
https://pubmed.ncbi.nlm.nih.gov/31532644
https://pubmed.ncbi.nlm.nih.gov/31532644
Autor:
Gustavo Pascual, Smriti Iyengar, Gregory A. Stephenson, Laura J. Martin, Sandra Ann Filla, Craig E. Thomas, Susan K. Hemrick-Luecke, Kirk W. Johnson, Jikesh Arvind Shah, Eric George Tromiczak, Magnus Wilhelm Walter, Karsten Fynboe, Lance Allen Pfeifer, Mark A. Muhlhauser, Juan A. Rincón, Nicolas Dreyfus, Chunjin Ding, Jia Shaojuan, María Luz de la Puente, Beverly A. Heinz, Lee A. Phebus, Michael P. Johnson, Simon James Richards, Thomas J. Perun, Michael J. McCoy, Pilar Lopez, Hamideh Zarrinmayeh, Thierry Masquelin, Rosa Maria A. Simmons, Douglas Linn Gernert, Oscar de Frutos, Elizabeth M. Joshi, Denise Morrow, Wayne W. Weber, Anette M. Johansson, Linda K. Thompson, Eric P. Seest, Valentina O. Badescu, Javier Mendiola, Jason K. Myers, Patrick L. Love
Publikováno v:
ACS Medicinal Chemistry Letters. 4:560-564
The objective of the described research effort was to identify a novel serotonin and norepinephrine reuptake inhibitor (SNRI) with improved norepinephrine transporter activity and acceptable metabolic stability and exhibiting minimal drug-drug intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f321ca4d944a7440cb435b08d880cf02
https://doi.org/10.1021/ml400049p
https://doi.org/10.1021/ml400049p
Publikováno v:
British Journal of Pharmacology. 161:1343-1350
BACKGROUND AND PURPOSE The two phenylpiperidines, OSU6162 and ACR16, have been proposed as novel drugs for the treatment of brain disorders, including schizophrenia and Huntington's disease, because of their putative dopamine stabilizing effects. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a22c8170a8173a4415485df9ccaffe83
https://doi.org/10.1111/j.1476-5381.2010.01010.x
https://doi.org/10.1111/j.1476-5381.2010.01010.x
Autor:
Sridhar Natesan, Karen B. L. Barlow, Kjell Svensson, José N. Nobrega, Anette M. Johansson, Shitij Kapur, Greg E. Reckless
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 318:810-818
“Dopamine stabilizers” are a new class of compounds that have the ability to reverse both hypo- as well as hyperdopaminergia in vivo. This class, exemplified by the phenylpiperidines ( S )-(-)-3-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9d9d2736c052ca08b2edf204ccd08a
https://doi.org/10.1124/jpet.106.102905
https://doi.org/10.1124/jpet.106.102905
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:747-750
The synthesis of novel C6-aryl substituted derivatives of 3-(dimethylamino)chroman is described. The novel derivatives display 5-HT(7) receptor affinities that varies from nM to muM, indicating that this small set of derivatives constitute a novel an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6f2b22e2e75b33368301ee1a5700ad
https://doi.org/10.1016/j.bmcl.2004.11.013
https://doi.org/10.1016/j.bmcl.2004.11.013
Autor:
Sverker Hanson, Rolf Johansson, Robert Leideborg, Nina Mohell, Susanne Rosqvist, Pär Holmberg, Patrizia Caldirola, Anette M. Johansson, Daniel Sohn, Gunnar Nordvall, Pavel Zlatoidsky
Publikováno v:
Journal of Medicinal Chemistry. 47:3927-3930
The understanding of the physiological role of the G-protein coupled serotonin 5-HT(7) receptor is largely rudimentary. Therefore, selective and potent pharmacological tools will add to the understanding of serotonergic effects mediated through this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1c9c989804d8eee6ba85323d052d38
https://doi.org/10.1021/jm0498102
https://doi.org/10.1021/jm0498102
Publikováno v:
Journal of Neurochemistry. 82:1106-1117
Mechanisms of ligand binding and receptor activation for the human D2(short) dopamine receptor have been probed using two homologous series of monohydroxylated and dihydroxylated agonists (phenylethylamines and 2-dipropylaminotetralins). In ligand bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cabb522b437b677ef0fbc97d698b57ab
https://doi.org/10.1046/j.1471-4159.2002.01046.x
https://doi.org/10.1046/j.1471-4159.2002.01046.x
Autor:
Anette M. Johansson, Torgny H. Svensson, Sandra Gordon, S.H.L. de Villiers, Nina Lindblom, Genadiy Kalayanov
Publikováno v:
Respiration. 69:254-260
Background: The presently available pharmaceutical aids in smoking cessation possess a rather limited effectiveness. Therefore, we have synthesized a series of immunoconjugates that stimulate the induction of antibodies which may bind nicotine in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93887adf541afd792f28cb6a3d0e7914
https://doi.org/10.1159/000063629
https://doi.org/10.1159/000063629
Autor:
Anette M. Johansson, Magnus Brisander, U. Hacksell, Tero Linnanen, Susanne Rosqvist, Lena Unelius, Gunnar Nordvall
Publikováno v:
Journal of Medicinal Chemistry. 44:1337-1340
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b279d8dfae9cc7e30e290d2c1c70d132
https://doi.org/10.1021/jm0108505
https://doi.org/10.1021/jm0108505