Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Anette Klinger"'
Autor:
Sara Abdelfatah, Angela Berg, Qi Huang, Li Jun Yang, Sami Hamdoun, Anette Klinger, Henry J. Greten, Edmond Fleischer, Thorsten Berg, Vincent K.W. Wong, Thomas Efferth
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 1021-1034 (2019)
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Po
Externí odkaz:
https://doaj.org/article/5d92f179f9394a6dad8794c0b9488b8b
Autor:
Julia Sachs, Katja Döhl, Anja Weber, Michele Bonus, Ferdinand Ehlers, Edmond Fleischer, Anette Klinger, Holger Gohlke, Jörg Pietruszka, Lutz Schmitt, Nicole Teusch
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Multidrug resistance (MDR) in tumors and pathogens remains a major problem in the efficacious treatment of patients by reduction of therapy options and subsequent treatment failure. Various mechanisms are described to be involved in the development o
Externí odkaz:
https://doaj.org/article/34ae5ab8192f4c63aca732d51ee02abb
Publikováno v:
Molecules, Vol 25, Iss 14, p 3224 (2020)
Nature is an indispensable source of new drugs, providing unique bioactive lead structures for drug discovery. In the present study, secalonic acid F (SAF), a naturally occurring ergochrome pigment, was studied for its cytotoxicity against various le
Externí odkaz:
https://doaj.org/article/036bc382ca714799b3432767f56a9b22
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126350 (2015)
To identify a novel class of inhibitors of fungal transporters involved in drug resistance.A series of structurally-related low molecular mass compounds was synthesized using combinatorial chemistry of a cyclobutene-dione (squarile) core. These compo
Externí odkaz:
https://doaj.org/article/7ec39290a1ee4fca9949113ce99c24e7
Autor:
Edmond Fleischer, Vincent Kam Wai Wong, Thorsten Berg, Sara Abdelfatah, Thomas Efferth, Anette Klinger, Li Jun Yang, Qi Huang, Sami Hamdoun, Henry Johannes Greten, Angela Berg
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 1021-1034 (2019)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ace647c8e4c5307f8c6cf16d50546d6
http://www.sciencedirect.com/science/article/pii/S221138351830827X
http://www.sciencedirect.com/science/article/pii/S221138351830827X
Autor:
Edmond Fleischer, Ge Yan, Mohamed-Elamir F. Hegazy, Thomas Efferth, Anette Klinger, Masashi Fukaya, Asmaa W. Zaglool, Mona Dawood
Publikováno v:
Investigational New Drugs. 38:650-661
Vitamin K3, also known as menadione, is a synthetic lipid-soluble 2-methyl-1,4- naphthoquinone analogs of vitamin K. The vitamin K derivatives exhibit potent cytotoxicity against several cancer cell lines through ROS induction and mitochondrial dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a83b25ed80d7f32cb1e2f23820a8e518
https://doi.org/10.1007/s10637-019-00810-7
https://doi.org/10.1007/s10637-019-00810-7
Publikováno v:
Investigational New Drugs. 38:1-9
PLK1 has an important role in the regulation of cell cycle and represents an important target for cancer treatment. This enzyme belongs to the Polo-like kinases family, which is characterized by a regulatory domain named Polo-box domain (PBD). Rather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393e66beaf59aef9b0aebb14104a2a20
https://doi.org/10.1007/s10637-019-00752-0
https://doi.org/10.1007/s10637-019-00752-0
Autor:
Nuha Mahmoud, Mohamed-Elamir F. Hegazy, Walaa Wadie, Mohamed Elbadawi, Edmond Fleischer, Anette Klinger, Gerhard Bringmann, Mohamed T. Khayyal, Thomas Efferth
Publikováno v:
Pharmacological Research. 179:106233
Inflammatory bowel disease (IBD) represents a chronic inflammation of the gastrointestinal tract characterized by an overreaction of immune responses and damage at the intestinal mucosal barrier. P-glycoprotein (P-gp) plays a key role to protect the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64edaf2ea00820da6d7a2381b1e55ba3
https://doi.org/10.1016/j.phrs.2022.106233
https://doi.org/10.1016/j.phrs.2022.106233
Publikováno v:
Investigational New Drugs
SummaryMultiple myeloma (MM) is a devastating disease with low survival rates worldwide. The mean lifetime of patients may be extendable with new drug alternatives. Aurora A kinase (AURKA) is crucial in oncogenesis, because its overexpression or ampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b69326e81c98777c1485bc2b66d5549
https://pubmed.ncbi.nlm.nih.gov/34705135
https://pubmed.ncbi.nlm.nih.gov/34705135
Autor:
Nicolas Fischer, Ean-Jeong Seo, Anette Klinger, Thomas Efferth, Sara Abdelfatah, Edmond Fleischer
Publikováno v:
Investigational New Drugs
SummaryIntroduction Differentiation therapy is a promising strategy for cancer treatment. The translationally controlled tumor protein (TCTP) is an encouraging target in this context. By now, this field of research is still at its infancy, which moti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc93eb59d0d59f7cb8eaf82a1b095f95
https://pubmed.ncbi.nlm.nih.gov/33492639
https://pubmed.ncbi.nlm.nih.gov/33492639