Pharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat.

Autor: Anette Ericsson, Nigel Turner, Göran I Hansson, Kristina Wallenius, Nicholas D Oakes

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113328 (2014)

The current study extends previously reported PPARα agonist WY 14,643 (30 µmol/kg/day for 4 weeks) effects on circulating amino acid concentrations in rats fed a 48% saturated fat diet. Steady-state tracer experiments were used to examine in vivo k

Externí odkaz: https://doaj.org/article/3d0041d436854e26bbf080bff08e6a53

Direct Drug Delivery to Kidney via the Renal Artery

Autor: Camilla Enggaard, Ulrika Dahlqvist, Jane Stubbe, Anna Björnson Granqvist, Magnus Söderberg, Alex-Xianghua Zhou, Tajana Tesan Tomic, Lena William-Olsson, Anette Ericsson

Publikováno v: Dahlqvist, U, Tomic, T T, Söderberg, M, Stubbe, J, Enggaard, C, Ericsson, A & Zhou, A-X 2021, ' Direct Drug Delivery to Kidney via the Renal Artery ', Journal of Visualized Experiments, vol. 170, e61932 . https://doi.org/10.3791/61932

There is a need for directed injections to enable increased and specific renal exposure for efficient evaluation of drug targets in the renal research field. Accumulation of drugs in certain organs may give rise to adverse and unwanted effects, depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b775e51d215091f9b7648d94835b0bc
https://doi.org/10.3791/61932-v

The effects of dual PPARα/γ agonism compared with ACE inhibition in the BTBRob/ob mouse model of diabetes and diabetic nephropathy

Autor: Lena William-Olsson, Sofia Tapani, Ann-Cathrine Jönsson-Rylander, Anette Ericsson, Alan Sabirsh, Mark Lal, Maria Strömstedt, Camilla Johansson, Gerhard Böttcher, Gina Hyberg, Robert J. Unwin, Pernilla Tonelius

Publikováno v: Physiological Reports

The leptin‐deficient BTBRob/ob mouse develops progressive albuminuria and morphological lesions similar to human diabetic nephropathy (DN), although whether glomerular hyperfiltration, a recognized feature of early DN that may contribute to renal i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a0bbd3f3624ce4241200c68baf86be
http://europepmc.org/articles/PMC5350186

Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport

Autor: Eleonor Sjöstrand, Thomas Jansson, Nina Jansson, Karin Säljö, Theresa L. Powell, Puttur D. Prasad, Anette Ericsson

Publikováno v: The Journal of Physiology. 581:1323-1332

In pregnant women with type 1 diabetes, suboptimal glucose control in the first trimester is a strong predictor for giving birth to a large fetus. However, the mechanisms underlying this association are unknown. We hypothesized that transient hypergl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33987b10689eb0b9c7fb3ba3f6e7d487
https://doi.org/10.1113/jphysiol.2007.131185

Gestational and hormonal regulation of human placental lipoprotein lipase

Autor: Thomas Jansson, Theresa L. Powell, Anette Ericsson, Anne Liese Magnusson-Olsson, Margareta Wennergren, Bengt Hamark

Publikováno v: Journal of Lipid Research, Vol 47, Iss 11, Pp 2551-2561 (2006)

The fetal demand for FFA increases as gestation proceeds, and LPL represents one potential mechanism for increasing placental lipid transport. We examined LPL activity and protein expression in first trimester and term human placenta. The LPL activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ff878b8706d13f832d105f269f1f57
https://doi.org/10.1194/jlr.m600098-jlr200