HepaChip-MP – a twenty-four chamber microplate for a continuously perfused liver coculture model

Autor: Meike Beer, Julia Schütte, Britta Hagmeyer, Tobias Klaassen, Simon Werner, Nicola Groll, Olena Tomilova, Rolf Gebhardt, Michael Pawlak, Dieter Runge, Juliane Schnabel, Simon Beuck, Jana Moer, Roland Hemmler, Marius Busche, Madlen Matz-Soja, Peter D. Jones, Anett Ullrich, Martin Stelzle, Holger Becker, Georg Damm, Christian Schmees, Karsten Gall, Katja Schenke-Layland

Publikováno v: Lab on a Chip. 20:2911-2926

HepaChip microplate (HepaChip-MP) is a microfluidic platform comprised of 24 independent culture chambers with continuous, unidirectional perfusion. In the HepaChip-MP, an automated dielectrophoresis process selectively assembles viable cells into el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cef2608a347556388e0bbc60d805a61
https://doi.org/10.1039/d0lc00357c

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Autor: Alejandro Aguayo-Orozco, Wolfgang Moritz, Wiebke Albrecht, Christoph van Thriel, Heidrun Ellinger-Ziegelbauer, Susann Fayyaz, Tobias S. Schiergens, Anne Cathrin Behr, Anett Ullrich, José V. Castell, Karolina Edlund, Franziska Kappenberg, Georg Damm, Leon van Aerts, Nachiket Vartak, Dieter Runge, Iain Gardner, Jörg Reinders, Ahmed Ghallab, Marcel Leist, Reinhard Kreiling, Agapios Sachinidis, Bård Smedsrød, Tim Brecklinghaus, Thomas Steger-Hartmann, Albert Braeuning, Anja Zeigerer, Daniel Seehofer, Thorsten Buhrke, Marianna Grinberg, Rosemarie Marchan, Laia Tolosa, Cristina Cadenas, Lars Kuepfer, Jörg Rahnenführer, Bob van de Water, Mian Zhang, Alfonso Lampen, Hendrik Kirschner, Regina Stoeber, Axel Oberemm, Kristina E Ebbert, Naim Kittana, Xiaolong Gu, Jan G. Hengstler, Klaus Golka, Ursula Gundert-Remy, Serene M. L. Lee

Publikováno v: Archives of Toxicology
ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Archives of toxicology, 93:1609-1637
Albrecht, W, Kappenberg, F, Brecklinghaus, T, Stoeber, R, Marchan, R, Zhang, M, Ebbert, K, Kirschner, H, Grinberg, M, Leist, M, Moritz, W, Cadenas, C, Ghallab, A, Reinders, J, Vartak, N, van Thriel, C, Golka, K, Tolosa, L, Castell, J V, Damm, G, Seehofer, D, Lampen, A, Braeuning, A, Buhrke, T, Behr, A-C, Oberemm, A, Gu, X, Kittana, N, van de Water, B, Kreiling, R, Fayyaz, S, van Aerts, L, Smedsrød, B, Ellinger-Ziegelbauer, H, Steger-Hartmann, T, Gundert-Remy, U, Zeigerer, A, Ullrich, A, Runge, D, Lee, S M L, Schiergens, T S, Kuepfer, L, Aguayo-Orozco, A, Sachinidis, A, Edlund, K, Gardner, I, Rahnenführer, J & Hengstler, J G 2019, ' Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations ', Archives of Toxicology, vol. 93, no. 6, pp. 1609-1637 . https://doi.org/10.1007/s00204-019-02492-9
Archives of Toxicology, 93(6), 1609-1637
Arch. Toxicol. 93, 1609-1637 (2019)

Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or the determination of an acceptable daily intake (ADI). To over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87870f4f6c75b48b42a60fa825d7108
https://doi.org/10.1007/s00204-019-02492-9

Pharmacokinetics and Pulmonary Distribution of Clarithromycin and Rifampicin after Concomitant and Consecutive Administration in Foals

Autor: Stefan Oswald, Werner Siegmund, Mahmoud Hasan, Monica Venner, Stefan Lumpe, Markus Keiser, Sarah Berlin, Markus Grube, Anett Ullrich, Lena Spieckermann

Publikováno v: Molecular Pharmaceutics. 13:1089-1099

Drug interactions often result from multiple pharmacokinetic changes, such as after rifampicin (RIF) and clarithromycin (CLA) in the treatment of abscessing lung diseases. Comedication of RIF may interact with CLA disposition by either induction of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf91a5929478d23602364b12664fe6e
https://doi.org/10.1021/acs.molpharmaceut.5b00907

Long term cultures of primary human hepatocytes as an alternative to drug testing in animals

Autor: Ewa Ellis, Dieter Runge, George K. Michalopoulos, Jan G. Hengstler, Stephen C. Strom, Anett Ullrich, Donna B. Stolz

Publikováno v: Karolinska Institutet

Due to species differences, primary human hepatocytes are still the in vitro system of choice to analyse liver specific processes and functions. Human hepatocytes were cultured for several weeks in a serum-free two-dimensional culture system, which w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46826f6e9b38569ce08994c0aeede3bc
https://doi.org/10.14573/altex.2009.4.295

Characterization of stably transfected HEK-293 cells expressing uptake transporters using fluorescent substances

Autor: Claudia Garve, Jia Jia, Dieter Runge, Markus Keiser, Anett Ullrich

Publikováno v: Toxicology Letters. 258:S127-S128

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a7ccef7b75b0a757ae75576d23da45a
https://doi.org/10.1016/j.toxlet.2016.06.1508