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pro vyhledávání: '"Anett Engel"'
Autor:
Anett Engel, Lena Ruhe, Neeraj Singh, Jo Anne Wright, Franziska Liesch, Friederike Bauland, Annika I. Ostermann, Tamara Sumalowitsch, Vincent J. T. Schweinsberg, Andrea Geistanger, Johannes Kolja Hegel, Christian Geletneky, Judith Taibon
Publikováno v:
Clinical Chemistry and Laboratory Medicine (CCLM).
ObjectivesTo develop an isotope dilution-liquid chromatography-tandem mass spectrometry-(ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for quantification of methotrexate in human serum and plasma.MethodsQuantitative nuclear magne
Publikováno v:
Molecular Pharmaceutics. 9:2577-2581
Although pharmaceutical excipients are supposed to be pharmacologically inactive, solubilizing agents like Cremophor EL have been shown to interact with cytochrome P450 (CYP)-dependent drug metabolism as well as efflux transporters such as P-glycopro