Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Anett, Sekora"'
Autor:
Anna Richter, Sandra Lange, Clemens Holz, Luisa Brock, Thomas Freitag, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Rico Schwarz, Burkhard Hinz, Hugo Murua Escobar, Christian Junghanss
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Dysregulation of the intrinsic BCL-2 pathway-mediated apoptosis cascade is a common feature of hematological malignancies including acute B-lymphoblastic leukemia (B-ALL). The KMT2A-rearranged high-risk cytogenetic subtype is characterized b
Externí odkaz:
https://doaj.org/article/f965715f9603445aaf305e682578afd1
Autor:
Annika Ladwig, Shailendra Gupta, Peter Ehlers, Anett Sekora, Moosheer Alammar, Dirk Koczan, Olaf Wolkenhauer, Christian Junghanss, Peter Langer, Hugo Murua Escobar
Publikováno v:
Molecules, Vol 28, Iss 24, p 8120 (2023)
Thiazolopyridines are a highly relevant class of small molecules, which have previously shown a wide range of biological activities. Besides their anti-tubercular, anti-microbial and anti-viral activities, they also show anti-cancerogenic properties,
Externí odkaz:
https://doaj.org/article/31bb6412557d40f1951e7c4e085f218c
Autor:
Wen Liu, Sina Sender, Weibo Kong, Julia Beck, Anett Sekora, Kirsten Bornemann-Kolatzki, Ekkehart Schuetz, Christian Junghanss, Bertram Brenig, Ingo Nolte, Hugo Murua Escobar
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Canine prostate cancer represents a unique model for human prostate cancer. In vitro systems offer various possibilities but Xenograft in vivo imaging allows studying complex tasks as tumor progression and drug intervention longit
Externí odkaz:
https://doaj.org/article/00421f6a31a74a6287c919c8e09eb195
Autor:
Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss, Catrin Roolf
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competi
Externí odkaz:
https://doaj.org/article/bf338d2f4e8c4aaaafa01b0ae93d5af2
Autor:
Anna Richter, Catrin Roolf, Mohamed Hamed, Yvonne Saara Gladbach, Sina Sender, Christoph Konkolefski, Gudrun Knübel, Anett Sekora, Georg Fuellen, Brigitte Vollmar, Hugo Murua Escobar, Christian Junghanss
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background The tumor suppressor protein phosphatase and tensin homolog (PTEN) is a key regulator of the PI3K/AKT pathway which is frequently altered in a variety of tumors including a subset of acute B-lymphoblastic leukemias (B-ALL). While
Externí odkaz:
https://doaj.org/article/4ab4ae59d44f423587e5d283cffbd82d
Autor:
Anna Richter, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Sandra Lange, Vivien Krebs, Bjoern Schneider, Johannes Lakner, Christoph Wittke, Christoph Kiefel, Irmela Jeremias, Hugo Murua Escobar, Brigitte Vollmar, Christian Junghanss
Publikováno v:
Cells, Vol 11, Iss 1, p 150 (2022)
In acute lymphoblastic leukemia (ALL), conventional cell lines do not recapitulate the clonal diversity and microenvironment. Orthotopic patient-derived xenograft models (PDX) overcome these limitations and mimic the clinical situation, but molecular
Externí odkaz:
https://doaj.org/article/21fdd92f54984c47a5294b6e0d5b6d24
Autor:
Sina Sender, Ahmad Wael Sultan, Daniel Palmer, Dirk Koczan, Anett Sekora, Julia Beck, Ekkehard Schuetz, Leila Taher, Bertram Brenig, Georg Fuellen, Christian Junghanss, Hugo Murua Escobar
Publikováno v:
Cancers; Volume 14; Issue 19; Pages: 4691
Background: Both bromodomain and extra-terminal domain (BET) proteins and spleen tyrosine kinase (SYK) represent promising targets in diffuse large B-cell (DLBCL) and Burkitt’s lymphoma (BL). We evaluated the anti-lymphoma activity of the isoform-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc2497b63801b6a18f4d1af5d518b9e
Autor:
Yixuan Ma, Benjamin Schulz, Nares Trakooljul, Moosheer Al Ammar, Anett Sekora, Sina Sender, Frieder Hadlich, Dietmar Zechner, Frank Weiss, Markus Lerch, Robert Jaster, Christian Junghanss, Hugo Murua Escobar
Publikováno v:
Cancers; Volume 14; Issue 18; Pages: 4467
Kirsten rat sarcoma virus (KRAS) mutations are widespread in pancreatic ductal adenocarcinoma (PDAC) and contribute significantly to tumor initiation, progression, tumor relapse/resistance, and prognosis of patients. Although inhibitors against KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff3afb5c326948bd6222b57f8ffa814
Autor:
Annika Eichhorst, Malte Gallhof, Alice Voss, Anett Sekora, Leon Eggers, Le Thi Huyen, Christian Junghanss, Hugo Murua Escobar, Malte Brasholz
Publikováno v:
ChemMedChem. 17(14)
Spirooxindole-1,3-oxazines are a small and structurally unique class of spirooxindole alkaloids. To date, only four of these compounds have been isolated from natural sources, and their biological properties remained unknown thus far. Dioxyreserpine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe793fe07525ce6151ff54dec2e51b6
https://pubmed.ncbi.nlm.nih.gov/35491398
https://pubmed.ncbi.nlm.nih.gov/35491398
Autor:
Christian Junghanss, Anett Sekora, Weibo Kong, Hugo Murua Escobar, Simon Villa Perez, Ingo Nolte, Sina Sender, Barbara C. Ruetgen
Publikováno v:
Anticancer Research. 40:3781-3792
Background/aim Canine B-cell lymphoma represents a useful in vivo model for human diffuse large B-cell lymphoma (DLBCL). Pan-Bromodomain and extra-terminal (BET) inhibition targeting BRD2/3/4 and selective inhibition of BRD4, as well as spleen tyrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dd9c7937cd8891b2f175e4f7469a51
https://doi.org/10.21873/anticanres.14367
https://doi.org/10.21873/anticanres.14367