Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anete, Rozkalne"'
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 3, Pp 650-654 (2011)
Synapse loss is the strongest correlate of cognitive decline in Alzheimer's disease, and synapses are an attractive therapeutic target due to their plastic nature that allows for potential recovery with intervention. We have previously demonstrated i
Externí odkaz:
https://doaj.org/article/af0dd59c04fc4d6b9a189384e08661b1
Autor:
Tara L. Spires-Jones, Matthew L. Mielke, Anete Rozkalne, Melanie Meyer-Luehmann, Alix de Calignon, Brian J. Bacskai, Dale Schenk, Bradley T. Hyman
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 2, Pp 213-220 (2009)
Senile plaque-associated changes in neuronal connectivity such as altered neurite trajectory, dystrophic swellings, and synapse and dendritic spine loss are thought to contribute to cognitive dysfunction in Alzheimer's disease and mouse models. Immun
Externí odkaz:
https://doaj.org/article/0e359a8abf9b4ab19794f2100faa8462
Autor:
Phillip B Jones, Kenneth W Adams, Anete Rozkalne, Tara L Spires-Jones, Tammy T Hshieh, Tadafumi Hashimoto, Christine A F von Armin, Mathew Mielke, Brian J Bacskai, Bradley T Hyman
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14586 (2011)
We applied a novel application of FLIM-FRET to in situ measurement and quantification of protein interactions to explore isoform specific differences in Aβ-ApoE interaction and ApoE tertiary conformation in senile plaques in human Alzheimer brain. A
Externí odkaz:
https://doaj.org/article/a075653211154ded91f8cb220fe6a7ec
Autor:
Anuradha Balasubramanian, Chiara Pantaleoni, Marina Mora, Peter B. Kang, M. Chiara Manzini, Mustafa A. Salih, Christine M. Sunu, Stefania Di Costanzo, Anete Rozkalne, Heather L. Pond, Emanuela Gussoni, Christopher A. Walsh, Timothy W. Yu, Vandana Gupta, Simona Saredi
Publikováno v:
Human Molecular Genetics. 23:5781-5792
Dystroglycan is a transmembrane glycoprotein whose interactions with the extracellular matrix (ECM) are necessary for normal muscle and brain development, and disruptions of its function lead to dystroglycanopathies, a group of congenital muscular dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2a3ab5db7f74233828b78202d7b5af
https://doi.org/10.1093/hmg/ddu296
https://doi.org/10.1093/hmg/ddu296
Autor:
Matthew S. Alexander, Alessandro Colletta, Elicia Estrella, Anete Rozkalne, Michael W. Lawlor, Janelle M. Spinazzola, Samuel K. Johnson, Louis M. Kunkel, Emanuela Gussoni, Fedik Rahimov, Hui Meng
Cell-surface markers for prospective isolation of stem cells from human skeletal muscle have been difficult to identify. Such markers would be powerful tools for studying satellite cell function during homeostasis and in pathogenesis of diseases such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bf31c2b5ad64b6583eb8ff9076e005
https://europepmc.org/articles/PMC5135584/
https://europepmc.org/articles/PMC5135584/
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 3, Pp 650-654 (2011)
Rozkalne, A, Hyman, B T & Spires-Jones, T L 2011, ' Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice ', Neurobiology of disease, vol. 41, no. 3, pp. 650-4 . https://doi.org/10.1016/j.nbd.2010.11.014
Rozkalne, A, Hyman, B T & Spires-Jones, T L 2011, ' Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice ', Neurobiology of disease, vol. 41, no. 3, pp. 650-4 . https://doi.org/10.1016/j.nbd.2010.11.014
Synapse loss is the strongest correlate of cognitive decline in Alzheimer's disease, and synapses are an attractive therapeutic target due to their plastic nature that allows for potential recovery with intervention. We have previously demonstrated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a1249fb2d50cfa57e28bafc5a24fff
http://www.sciencedirect.com/science/article/pii/S096999611000389X
http://www.sciencedirect.com/science/article/pii/S096999611000389X
Autor:
Bradley T. Hyman, Anete Rozkalne, Cynthia L. Grosskreutz, Brian J. Bacskai, Hai Yan Wu, Tadafumi Hashimoto, Tara L. Spires-Jones, Eloise Hudry, Kishore V. Kuchibhotla, Michal Arbel-Ornath, Hong Xie, Zhanyun Fan
Publikováno v:
Wu, H-Y, Hudry, E, Hashimoto, T, Kuchibhotla, K, Rozkalne, A, Fan, Z, Spires-Jones, T, Xie, H, Arbel-Ornath, M, Grosskreutz, C L, Bacskai, B J & Hyman, B T 2010, ' Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation ', Journal of Neuroscience, vol. 30, no. 7, pp. 2636-49 . https://doi.org/10.1523/JNEUROSCI.4456-09.2010
Amyloid beta (Abeta)-containing plaques are surrounded by dystrophic neurites in the Alzheimer's disease (AD) brain, but whether and how plaques induce these neuritic abnormalities remain unknown. We tested the hypothesis that soluble oligomeric asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91cb1c3f4d7c3df1f11f2574c9f0233
https://doi.org/10.1523/jneurosci.4456-09.2010
https://doi.org/10.1523/jneurosci.4456-09.2010
Publikováno v:
Rozkalne, A, Spires-Jones, T L, Stern, E A & Hyman, B T 2009, ' A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model ', Brain Research, vol. 1280, pp. 178-85 . https://doi.org/10.1016/j.brainres.2009.05.045
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs memory and cognition. One of the major neuropathological hallmarks is the accumulation of the extracellular senile plaques that are mainly composed of amyloid beta (Abeta) protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a6a8f61271bd7f7716ef8013c0e53c
https://doi.org/10.1016/j.brainres.2009.05.045
https://doi.org/10.1016/j.brainres.2009.05.045
Publikováno v:
Journal of Neurochemistry. 102:1095-1104
Alzheimer’s disease (AD) is characterized by senile plaques and neurodegeneration although the neurotoxic mechanisms have not been completely elucidated. It is clear that both oxidative stress and inflammation play an important role in the illness.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53df668a677861f8a3ffb5252e8acabf
https://doi.org/10.1111/j.1471-4159.2007.04613.x
https://doi.org/10.1111/j.1471-4159.2007.04613.x
Autor:
Anete Rozkalne, Genri Kawahara, Anuradha Balasubramanian, Ariane Beauvais, Louis M. Kunkel, Vandana Gupta, Emanuela Gussoni
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(7)
Previously, we identified family with sequence similarity 65, member B (Fam65b), as a protein transiently up-regulated during differentiation and fusion of human myogenic cells. Silencing of Fam65b expression results in severe reduction of myogenin e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3229406b112d1bd3af3151af0100d6
https://pubmed.ncbi.nlm.nih.gov/24687993
https://pubmed.ncbi.nlm.nih.gov/24687993