Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Aneta Lukaszuk"'
Autor:
Isabelle Van den Eynde, Patrick Vanderheyden, Georges Vauquelin, Heidi Demaegdt, Aneta Lukaszuk, Dirk Tourwé
Publikováno v:
Journal of Peptide Science. 17:545-553
The aromatic amino acids Tyr and Phe in angiotensin IV (Ang IV) were conformationally constrained by the use of β-Me substituted analogs, or cyclic constrained analogs. None of these modifications was allowed for Tyr¹, while only e-β-MePhe⁶ subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e657fdb57bcad7b74f9c3142f9d8dc
https://doi.org/10.1002/psc.1365
https://doi.org/10.1002/psc.1365
Autor:
Georges Vauquelin, Géza Tóth, Jean-Paul De Backer, Erzsébet Szemenyei, Heidi Demaegdt, Aneta Lukaszuk, Dirk Tourwé
Publikováno v:
Fundamental & Clinical Pharmacology. 26:194-197
Radioligand binding studies revealed that Ang IV binds to insulin-regulated aminopeptidase (IRAP)/'AT(4) receptors' with high affinity. Yet, as these experiments were routinely carried out in the presence of chelators, only the catalytic zinc-deplete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca667bf280d3d25bb25e563a8088f9d9
https://doi.org/10.1111/j.1472-8206.2011.00948.x
https://doi.org/10.1111/j.1472-8206.2011.00948.x
Autor:
Tobias Heck, Dieter Seebach, Birgit Geueke, Aneta Lukaszuk, Artur Reimer, James Gardiner, Hans-Peter E. Kohler, Gildas Deniau
Publikováno v:
ChemBioChem. 11:1129-1136
We have previously shown that the beta-aminopeptidases BapA from Sphingosinicella xenopeptidilytica and DmpA from Ochrobactrum anthropi can catalyze reactions with non-natural beta(3)-peptides and beta(3)-amino acid amides. Here we report that these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e340a5c44e44642750d4fc16293325
https://doi.org/10.1002/cbic.200900757
https://doi.org/10.1002/cbic.200900757
Autor:
Aneta Lukaszuk, Jean-Paul De Backer, Sridhara Chakravarthy, Géza Tóth, Dirk Tourwé, Erzsébet Szemenyei, Heidi Demaegdt, Yvette Michotte, Evi De Buyser, Georges Vauquelin, Mitradas M. Panicker
Publikováno v:
Molecular and Cellular Endocrinology. 311:77-86
‘AT4 receptors’ through which Angiotensin IV (Ang IV) improves memory acquisition, were recently identified as insulin regulated aminopeptidase (IRAP). Radioligand binding studies have hitherto been performed with iodinated Ang IV in the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9d12c63cc2ed3178c7c2b7fc0c5e21
https://doi.org/10.1016/j.mce.2009.07.020
https://doi.org/10.1016/j.mce.2009.07.020
Autor:
Dirk Tourwé, Erzsebet Szemenyei, Dagmara Tymecka, Aleksandra Misicka, Georges Vauquelin, Philippe Karoyan, Aneta Lukaszuk, Heidi Demaegdt, Patrick Vanderheyden, Géza Tóth
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2008, 51 ((7)), pp.2291-6. ⟨10.1021/jm701490g⟩
Journal of Medicinal Chemistry, 2008, 51 ((7)), pp.2291-6. ⟨10.1021/jm701490g⟩
Journal of Medicinal Chemistry, American Chemical Society, 2008, 51 ((7)), pp.2291-6. ⟨10.1021/jm701490g⟩
Journal of Medicinal Chemistry, 2008, 51 ((7)), pp.2291-6. ⟨10.1021/jm701490g⟩
International audience; Angiotensin IV, a metabolite of angiotensin II, inhibits the enzyme insulin regulated aminopeptidase or IRAP and also, although with lower potency, aminopeptidase-N (AP-N). When both beta (2)-homo amino acid- and beta (3)-homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9c11c2cc7ebd3a17c01cfe5de6e89c
https://doi.org/10.1021/jm701490g
https://doi.org/10.1021/jm701490g
Autor:
Beatrice Waser, Renzo Cescato, Dominika Jadwiga Podwysocka, Peter Gmeiner, Catherine Rougeot, Krystyna Patora-Komisarska, Dieter Seebach, Marc-Olivier Ebert, Jean Claude Reubi, James Gardiner, Harald Hübner, Aneta Lukaszuk
Publikováno v:
Chemistrybiodiversity. 8(5)
The terminal homologation by CH(2) insertion into the peptides mentioned in the title is described. This involves replacement of the N-terminal amino acid residue by a β(2) - and of the C-terminal amino acid residue by a β(3) -homo-amino acid moiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9994aae437aa396bc3895b6e798652
https://pubmed.ncbi.nlm.nih.gov/21560227
https://pubmed.ncbi.nlm.nih.gov/21560227
Autor:
Heidi, Demaegdt, Jean-Paul, De Backer, Aneta, Lukaszuk, Géza, Tóth, Erzsébet, Szemenyei, Dirk, Tourwé, Georges, Vauquelin
Publikováno v:
Fundamentalclinical pharmacology. 26(2)
Radioligand binding studies revealed that Ang IV binds to insulin-regulated aminopeptidase (IRAP)/'AT(4) receptors' with high affinity. Yet, as these experiments were routinely carried out in the presence of chelators, only the catalytic zinc-deplete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab8f4baca296bd59c1a4cfdf4e0b3ae7
https://pubmed.ncbi.nlm.nih.gov/21477268
https://pubmed.ncbi.nlm.nih.gov/21477268
Autor:
Aneta Lukaszuk, Dirk Tourwé, Paul R. Gard, Georges Vauquelin, Erzsébet Szemenyei, Jean-Paul De Backer, Heidi Demaegdt, Géza Tóth
Insulin regulated aminopeptidase (IRAP) recognises "AT(4)-receptor" ligands like angiotensin IV (Ang IV) and peptidomimetics like AL-11. The metabolic stability and high affinity of [(3)H]AL-11 for catalytically active IRAP allowed its detection in C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1938f3b146b8bea3fbdf624c084f1a
https://hdl.handle.net/20.500.14017/ca5c56cd-5efe-4b63-ba63-34efd096bbb2
https://hdl.handle.net/20.500.14017/ca5c56cd-5efe-4b63-ba63-34efd096bbb2
Radical Stability Directs Electron Capture and Transfer Dissociation of beta-Amino Acids in Peptides
Autor:
Philippe Karoyan, Aleksey Vorobyev, Yury O. Tsybin, Aneta Lukaszuk, Solange Lavielle, Dirk Tourwé, Hisham Ben Hamidane, Maud Larregola
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2010, 16 (15), pp.4612-4622. ⟨10.1002/chem.200902480⟩
Chemistry-A European Journal, 2010, 16 (15), pp.4612-4622. ⟨10.1002/chem.200902480⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2010, 16 (15), pp.4612-4622. ⟨10.1002/chem.200902480⟩
Chemistry-A European Journal, 2010, 16 (15), pp.4612-4622. ⟨10.1002/chem.200902480⟩
We report on the characteristics of the radical-ion-driven dissociation of a diverse array of beta-amino acids incorporated into alpha-peptides, as probed by tandem electron-capture and electron-transfer dissociation (ECD/ETD) mass spectrometry. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d23bc7f3da45797121fa1fcded092fc
https://hal.archives-ouvertes.fr/hal-00526369
https://hal.archives-ouvertes.fr/hal-00526369
Autor:
Albert Geerts, Tamara Vanhaecke, Aneta Lukaszuk, Dirk Tourwé, Tatyana Y. Doktorova, Vera Rogiers, Sarah Deleu, Joanna Fraczek, Karin Vanderkerken
Publikováno v:
Vrije Universiteit Brussel
The vast majority of preclinical studies of HDAC inhibitors (HDAC-I) focus on the drug-target (cancer) cell interaction, whereas little attention is paid to the effects on non-target healthy cells, which could provide decisive information to eliminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb9cc351567a1e82747cfa9e8651145
https://biblio.vub.ac.be/vubir/screening-of-amide-analogues-of-trichostatin-a-in-cultures-of-primary-rat-hepatocytes-search-for-potent-and-safe-hdac-inhibitors(7a8bd47d-3511-4cce-a2e0-e53a0e8fb1e3).html
https://biblio.vub.ac.be/vubir/screening-of-amide-analogues-of-trichostatin-a-in-cultures-of-primary-rat-hepatocytes-search-for-potent-and-safe-hdac-inhibitors(7a8bd47d-3511-4cce-a2e0-e53a0e8fb1e3).html