Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive

Autor: Erin W. Meermeier, Christina L. Zheng, Jessica G. Tran, Shogo Soma, Aneta H. Worley, David I. Weiss, Robert L. Modlin, Gwendolyn Swarbrick, Elham Karamooz, Sharon Khuzwayo, Emily B. Wong, Marielle C. Gold, David M. Lewinsohn

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)

Human lung-resident MAIT cells are distinct from CD8+ T cells. They are polycytotoxic, secrete the directly antimicrobial molecule IL-26, express genes associated with persistence, and selectively express interferon-γ- and IL-12- receptors.

Externí odkaz: https://doaj.org/article/d3ef35794a73444aa9aa0c8fe8dffb79

Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive

Autor: Erin W, Meermeier, Christina L, Zheng, Jessica G, Tran, Shogo, Soma, Aneta H, Worley, David I, Weiss, Robert L, Modlin, Gwendolyn, Swarbrick, Elham, Karamooz, Sharon, Khuzwayo, Emily B, Wong, Marielle C, Gold, David M, Lewinsohn

Publikováno v: Communications biology. 5(1)

Mucosal-associated Invariant T (MAIT) cells are an innate-like T cell subset that recognize a broad array of microbial pathogens, including respiratory pathogens. Here we investigate the transcriptional profile of MAIT cells localized to the human lu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::82c8848250263f86933eedcac2f058c6
https://pubmed.ncbi.nlm.nih.gov/36085311

Intracellular Sampling of Mycobacterium Tuberculosis by MR1: Key Role for Syntaxin 16

Autor: Gitanjali A. Narayanan, D.M. Lewinsohn, Fikadu G. Tafesse, Melanie J. Harriff, Aneta H. Worley, Elham Karamooz

Publikováno v: C106. BASIC AND TRANSLATIONAL DISCOVERIES IN TB AND MYCOBACTERIAL DISEASES.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::348967a224e63bd1ca9167061d5c9a67
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6084

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

Autor: Prinita Baijnath, Leon Naidoo, Eisa Mahyari, Bongiwe Z. Xulu, Kelly L. Miners, William R. Bishai, Umesh G. Lalloo, Morten Nielsen, Moosa Suleman, Victoria O. Kasprowicz, Rajhmun Madansein, Thumbi Ndung'u, Prabhat K. Sharma, Erin W. Meermeier, David M. Lewinsohn, David Price, Aneta H. Worley, Sharon Khuzwayo, Emily B. Wong, Marielle C. Gold, Zoe Rogers, Zuri A. Sullivan, Alasdair Leslie, Henrik N. Kløverpris, James E. McLaren, Kristin Ladell, Samuel M. Behar, Anish Ambaram

Publikováno v: Communications Biology
Wong, E B, Gold, M C, Meermeier, E W, Xulu, B Z, Khuzwayo, S, Sullivan, Z A, Mahyari, E, Rogers, Z, Kløverpris, H, Sharma, P K, Worley, A H, Lalloo, U, Baijnath, P, Ambaram, A, Naidoo, L, Suleman, M, Madansein, R, McLaren, J E, Ladell, K, Miners, K L, Price, D A, Behar, S M, Nielsen, M, Kasprowicz, V O, Leslie, A, Bishai, W R, Ndung'u, T & Lewinsohn, D M 2019, ' TRAV1-2 + CD8 + T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis ', Communications Biology, vol. 2, 203 . https://doi.org/10.1038/s42003-019-0442-2
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Wong, E B, Gold, M C, Meermeier, E W, Xulu, B Z, Khuzwayo, S, Sullivan, Z A, Mahyari, E, Rogers, Z, Kløverpris, H, Sharma, P K, Worley, A H, Lalloo, U, Baijnath, P, Ambaram, A, Naidoo, L, Suleman, M, Madansein, R, McLaren, J E, Ladell, K, Miners, K L, Price, D A, Behar, S M, Nielsen, M, Kasprowicz, V O, Leslie, A, Bishai, W R, Ndung’u, T & Lewinsohn, D M 2019, ' TRAV1-2 + CD8 + T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis ', Communications Biology, vol. 2, no. 1, 203 . https://doi.org/10.1038/s42003-019-0442-2

Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2+ semi-invariant TCRα that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4817cecf805d1a194b666c2f42cd6a6b

TRAV1-2

Autor: Emily B, Wong, Marielle C, Gold, Erin W, Meermeier, Bongiwe Z, Xulu, Sharon, Khuzwayo, Zuri A, Sullivan, Eisa, Mahyari, Zoe, Rogers, Hénrik, Kløverpris, Prabhat K, Sharma, Aneta H, Worley, Umesh, Lalloo, Prinita, Baijnath, Anish, Ambaram, Leon, Naidoo, Moosa, Suleman, Rajhmun, Madansein, James E, McLaren, Kristin, Ladell, Kelly L, Miners, David A, Price, Samuel M, Behar, Morten, Nielsen, Victoria O, Kasprowicz, Alasdair, Leslie, William R, Bishai, Thumbi, Ndung'u, David M, Lewinsohn

Publikováno v: Communications Biology

Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2+ semi-invariant TCRα that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fad175dd76325027c148a7935e8e027
https://pubmed.ncbi.nlm.nih.gov/31231693