Astrocyte Specific Remodeling of Plasmalemmal Cholesterol Composition by Ketamine Indicates a New Mechanism of Antidepressant Action

Autor: Eva Lasič, Marjeta Lisjak, Anemari Horvat, Mićo Božić, Aleksandra Šakanović, Gregor Anderluh, Alexei Verkhratsky, Nina Vardjan, Jernej Jorgačevski, Matjaž Stenovec, Robert Zorec

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

Abstract Ketamine is an antidepressant with rapid therapeutic onset and long-lasting effect, although the underlying mechanism(s) remain unknown. Using FRET-based nanosensors we found that ketamine increases [cAMP]i in astrocytes. Membrane capacitanc

Externí odkaz: https://doaj.org/article/9d2c933be99348ce80c4952f5d5ca559

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP

Autor: Nina Vardjan, Helena H. Chowdhury, Anemari Horvat, Jelena Velebit, Maja Malnar, Marko Muhič, Marko Kreft, Špela G. Krivec, Saša T. Bobnar, Katarina Miš, Sergej Pirkmajer, Stefan Offermanns, Gjermund Henriksen, Jon Storm-Mathisen, Linda H. Bergersen, Robert Zorec

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Besides being a neuronal fuel, L-lactate is also a signal in the brain. Whether extracellular L-lactate affects brain metabolism, in particular astrocytes, abundant neuroglial cells, which produce L-lactate in aerobic glycolysis, is unclear. Recent s

Externí odkaz: https://doaj.org/article/eccf9693d6d643ec98be6c24d4620e27

Astrocyte arborization enhances Ca 2+ but not cAMP signaling plasticity

Autor: Matjaž Stenovec, Dorian Dolanc, Samo Pirnat, Anemari Horvat, Mićo Božić, Nina Vardjan, Robert Zorec, Alexei Verkhratsky, Petra Tavčar

Publikováno v: Glia, vol. 69, no. 12, pp. 2899-2916, 2021.
Pirnat, S, Božić, M, Dolanc, D, Horvat, A, Tavčar, P, Vardjan, N, Verkhratsky, A, Zorec, R & Stenovec, M 2021, ' Astrocyte arborization enhances Ca2+ but not cAMP signaling plasticity ', GLIA . https://doi.org/10.1002/glia.24076

The plasticity of astrocytes is fundamental for their principal function, maintaining homeostasis of the central nervous system throughout life, and is associated with diverse exposomal challenges. Here, we used cultured astrocytes to investigate at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca2a647166e6f108767cdc8431b5d60
https://doi.org/10.1002/glia.24076

Astrocytes with TDP-43 inclusions exhibit reduced noradrenergic cAMP and Ca2+ signaling and dysregulated cell metabolism

Autor: Robert Zorec, Tina Smolič, Nina Vardjan, Jelena Velebit, Anemari Horvat, Boris Rogelj, Sonja Prpar Mihevc

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific reports, vol. 10, 6003, 2020.

Most cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have cytoplasmic inclusions of TAR DNA-binding protein 43 (TDP-43) in neurons and non-neuronal cells, including astrocytes, which metabolically support neurons with n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5241153231dfac581c32c25d49861e
http://link.springer.com/article/10.1038/s41598-020-62864-5

Astrocyte arborization enhances Ca

Autor: Samo, Pirnat, Mićo, Božić, Dorian, Dolanc, Anemari, Horvat, Petra, Tavčar, Nina, Vardjan, Alexei, Verkhratsky, Robert, Zorec, Matjaž, Stenovec

Publikováno v: Glia. 69(12)

The plasticity of astrocytes is fundamental for their principal function, maintaining homeostasis of the central nervous system throughout life, and is associated with diverse exposomal challenges. Here, we used cultured astrocytes to investigate at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5a72b0976c366ffb48429e737e12afb
https://pubmed.ncbi.nlm.nih.gov/34406698